Principal Scientist, Formulations

Scorpion Therapeutics; Watertown (MA); On-site; USD 180,000 - 280,000; Full time

Job summary

Scorpion Therapeutics in Massachusetts is seeking a Lead Formulation Development and Manufacturing Scientist to drive early‑clinical formulation strategies for small molecule candidates. You will design, optimize, and scale robust oral dosage forms, oversee process development, tech transfer, and GMP manufacturing, and coordinate with external CDMOs and internal R&D, QA, Supply Chain teams.

PhD with 8+ years in formulation science and GMP scale‑up is required; strong regulatory documentation

Qualifications

• PhD required with 8+ years in formulation, process optimization, scale-up, and GMP manufacturing.
• Deep knowledge of QbD, cGMP, and regulatory standards.
• Experience managing CDMOs and authoring regulatory submissions.

Responsibilities

• Design, optimize, and scale robust formulations aligned with target profiles.
• Oversee process development, technology transfer, and GMP manufacturing.
• Manage external CDMOs, review production records, and ensure quality compliance.
• Support regulatory documentation including INDs and IMPDs.
• Serve as a technical liaison across R&D, Supply Chain, QA, and external partners.

Skills

Formulation science

Process optimization

Technology transfer

GMP manufacturing

Education

PhD in Pharmaceutical Chemistry or Formulation Sciences

Job description

Role

Lead formulation development and manufacturing scale-up for small molecule oral drug candidates in early clinical stages.

Responsibilities

• design, optimize, and scale robust formulations aligned with target profiles
• oversee process development, technology transfer, and GMP manufacturing
• manage external CDMOs, review production records, and ensure quality compliance
• support regulatory documentation including INDs and IMPDs
• serve as a technical liaison across R&D, Supply Chain, QA, and external partners

Requirements

• PhD in Pharmaceutical Chemistry, Formulation Sciences, or related field
• 8+ years industry experience in formulation, process optimization, scale-up, and GMP manufacturing of small molecule oral/parenteral dosage forms
• deep knowledge of QbD, cGMP, and regulatory standards
• experience managing CDMOs and authoring regulatory documents

Preferred

strong cross-functional leadership, excellent communication, multitasking skills, and proven success in clinical-stage drug development.

High-Value

small molecule drug products, oral solid dose, early-phase clinical development, GMP manufacturing, CDMO management, regulatory documentation (INDs/IMPDS), cross-disciplinary collaboration.

WorkSetup

not specified.