Principal Scientist, Discovery Process Chemistry (DPC)

MSD; Boston (MA); Vor Ort; USD 176.000 - 277.000; Vollzeit

Benefits dieser Stelle

Annual bonus

Long-term incentive

Medical, dental, vision insurance

401(k) plan

Zusammenfassung

Merck & Co., Inc. in Boston, MA seeks a Principal Scientist to lead the Discovery Process Chemistry (DPC) group.

You will shape synthetic strategies for diverse medicinal chemistry programs, mentor scientists, and drive scalable routes from lead identification to candidate selection. The role demands a PhD in Organic Chemistry, a track record in medicinal/process chemistry, and strong collaboration across cross-functional teams, with a focus on innovative solutions and external publication

Qualifikationen

• PhD in Organic Chemistry required.
• Minimum 5 years of proven research excellence in medicinal or process chemistry.
• Experience leading and mentoring scientists in a DPC or related setting.
• Strong written and oral communication skills; cross-functional collaboration.

Aufgaben

• Lead a team of scientists in discovery process chemistry across multiple modalities.
• Define scalable synthetic routes and transition candidates from discovery to early development.
• Oversee API supply at various scales during discovery and development.
• Collaborate with Medicinal and Process Chemistry and other discovery groups; contribute to external publications and presentations.

Kenntnisse

Bioconjugation

Clinical Chemistry

Computational Chemistry

High-Throughput Experimentation

Inorganic Synthesis

Medicinal Chemistry

Organic Chemistry

Organic Synthesis

Organometallic Chemistry

Preclinical Research

Process Chemistry

Scientific Publishing

Structure Based Drug Design

Synthetic Chemistry

Ausbildung

PhD in Organic Chemistry

Jobbeschreibung

Principal Scientist, Discovery Process Chemistry (DPC)*This site uses cookies to provide you with an optimal user experience. The cookies include Strictly Necessary and Functional cookies to ensure the site operates as intended (language preference, time zone and workload balance). These cookies are first party cookies, end with the session and are exempted from consent. In addition, this site also uses a Google Analytics Cookie to measure and improve the performance of our site. All information these cookies collect is aggregated and therefore anonymous. By clicking on the ‘Accept Cookies’ button, you are accepting this Performance cookie. You may use this site if you click on the ‘Reject Cookies’ button. To revoke your consent of the Performance cookie, clear your cookies within your browser settings.*### Principal Scientist, Discovery Process Chemistry (DPC)Apply: Not Applicable: USA - Massachusetts - Boston (MA Parcel B Laboratory): Full time: Posted Today: End Date: November 28, 2026 (23 days left to apply): R425368**Job Description**Our Company is currently seeking an exceptional scientific leader for our Discovery Process Chemistry (DPC) group at our Boston, MA site. The core responsibility of the successful candidate will be to lead a team of scientists in the development of innovative solutions to complex chemistry problems across a diverse portfolio of projects and modalities in the discovery phase, from lead identification through candidate selection, with the goal to apply these solutions to facilitate medicinal chemistry research by overcoming synthetic bottlenecks, streamlining SAR analogue synthesis, and providing access to novel chemical space. The position is also responsible for defining scalable synthetic routes and successfully transitioning candidate compounds from discovery into early development, as well as managing supply of Active Pharmaceutical Ingredients (APIs) at varying scales during this period. Close collaboration with chemistry colleagues in Medicinal Chemistry and Process Chemistry, as well as a broad array of other discovery and preclinical research groups, will be expected. As such, subject matter expertise in Medicinal or Process Chemistry is critical. The candidate must be highly self-motivated, demonstrate strong leadership, possess strong experimental skills, have excellent written and oral communication abilities, collaborate effectively on multidisciplinary teams, and be able to demonstrate flexibility in adapting to change in a fast-paced, dynamic research environment. In addition to supervising direct scientific reports, the candidate is also expected to provide broader mentorship and expertise across the DPC group. The candidate will be expected to remain current with the latest synthetic methodologies, drive innovation, actively apply new concepts to continuously improve PR&D capabilities and expertise, and be active in the external scientific community via publications and external presentations. **Position Qualifications****Education Requirement:*** PhD in Organic Chemistry **Required Experience and Skills:*** A minimum of 5 years experience with a proven track record of scientific excellence and successful research* Expertise in organic synthesis* Demonstrated creativity and innovation in problem solving* Productivity and efficiency working in the lab* Proven track record of successful research in medicinal and/or process chemistry* Strong written and oral communication skills* Excellent collaboration skills* Ability to contribute to and lead cross-functional teams and influence team strategy and decision-making* Established scientific reputation supported by publications and external presentations* Demonstrated ability to develop talent **Required Skills:**Bioconjugation, Clinical Chemistry, Computational Chemistry, High-Throughput Experimentation (HTE), Inorganic Synthesis, Medicinal Chemistry, Organic Chemistry, Organic Synthesis, Organometallic Chemistry, Preclinical Research, Process Chemistry, Scientific Publishing, Structure Based Drug Design, Synthetic Chemistry**Preferred Skills:**Current Employees apply HERECurrent Contingent Workers apply HERE**US and Puerto Rico Residents Only:**Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:EEOC Know Your RightsEEOC GINA SupplementWe are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.Learn more about your rights, including under California, Colorado and other US State Acts The primary location for this posting is:USA - Massachusetts - Boston (MA Parcel B Laboratory) Where required by law, the compensation range for this role is provided below. The salary range for the primary location of this role is:$176,200.00 - $277,300.00 This range reflects the Company's reasonable expectation of the base salary applicable to this role at the time of posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits. **Additional location(s):** Please note the salary range above applies to the Primary Location of the position. Where a role has other listed locations, different compensation guidelines may apply. You may find the salary ranges for additional locations below. If the salary range is not listed for the location you are applying to, our Talent Acquisition team will provide further information to you relevant to your location. **Additional location(s) Compensation Information:****San Francisco Residents Only:** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance**Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance**Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.**Employee Status:**Regular**Relocation:**Domestic**VISA Sponsorship:**Yes**Travel Requirements:**10%**Flexible Work Arrangements:**Not Applicable**Shift:**Not Indicated**Valid Driving License:**No**Hazardous Material(s):**n/a**Job Posting End Date:**11/28/2026**\\*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.**