Principal Scientist - Cell Therapy Translational Research

Bristol-Myers Squibb Company; Seattle (WA); On-site; USD 152,000 - 185,000; Full time

Benefits offered by this job

Flexible Time Off

11 paid company holidays

Global Shutdown

Job summary

Bristol Myers Squibb seeks an experienced translational research scientist to support cell therapy development in autoimmune and inflammatory diseases. You will design and implement translational strategies, work with CROs, and develop biomarker plans to support clinical studies in Seattle.

The role emphasizes pharmacodynamic evaluation, mechanism of action insights, and collaboration across internal teams and external partners to advance cellular therapeutics through regulatory milestones.

Qualifications

• Bachelor’s Degree with 8+ years in life sciences, or Master’s with 6+ years, or Ph.D. with 4+ years.
• Experience in translational research and biomarker development for cell therapy.
• Strong communication and ability to work with CROs and collaborators.

Responsibilities

• Develop and implement end-to-end translational research strategies for cell therapy clinical trials.
• Partner with biostatisticians and computational biologists for data analysis and reporting.
• Develop MOA hypotheses and identify distinguishing features of BMS cell therapy products.
• Maintain knowledge of biomarker assays including flow cytometry, transcriptomics, proteomics.
• Independently manage internal projects in cell therapy drug development.
• Contribute to regulatory submissions and interactions, and support translation sections.

Skills

Translational research

Cell therapy

Biomarker analysis

Flow cytometry

Transcriptomics

Proteomics

Data analysis

Cross-functional collaboration

Regulatory writing

Education

Bachelor’s Degree

Master’s Degree

Ph.D. or equivalent advanced degree in the Life Sciences

Job description

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

The Cell Therapy Thematic Research Center is one of BMS’s differentiated research platforms delivering innovative therapies to patients. Our mission is to drive leadership in the use of cellular therapies to harness the power of the immune system in treating hematologic malignancies, solid cancers, and autoimmune disease. More specifically, our discovery and translational scientists are focused on developing next-generation, engineered cell-based therapies. The team is committed to discovering and developing transformative therapies that harness the power of the immune system to improve patient outcomes.

Position Summary

The candidate will join the Cellular Therapy Translational Research group in Seattle, WA and will support cell therapy development programs in autoimmune and inflammatory diseases. The successful candidate will be an experienced, self-motivated, and resourceful researcher responsible for driving and implementing translational development strategies and clinical biomarker plans for BMS cellular therapy clinical studies. The individual will work with contract research organizations, and internal and external collaborators, to design, execute, and interpret translationally focused experiments and analyses. Activities include biomarker identification, generation and analysis of data that support pharmacodynamic evaluation and mechanism of action in the clinical trial setting to inform development of cell therapy products, as well as contribute to relevant global regulatory submission activities to advance cellular therapeutics.

Position Responsibilities

• Develop and implement end-to-end translational research strategies for cell therapy clinical trials
• Partner with biostatisticians and computational biologists to provide timely analysis and communication of data and present its context and impact
• Develop concepts and mechanism of action hypotheses identifying distinguishing characteristics of BMS cell therapy products alone or in combination with other therapies
• Maintain a deep understanding of biomarker assays including flow cytometry, transcriptomics, proteomics and the application and use of these technologies in the clinical trial setting
• Independently manage internal projects in cell therapy drug development
• Serve on internal cross functional project teams and committees as scientific functional lead
• Oversight and management of CROs and academic collaborators
• Communicate regularly and prepare and make presentations within the department, externally, and to internal governance committees as required.
• Contribute to the writing of investigator brochures, IND applications, clinical protocols, regulatory annual reports, and other regulatory documents when appropriate
• Support regulatory submissions and interactions, write/review translational sections for global regulatory response and queries

#LI-Onsite

Experience

Basic Qualifications

• Bachelor’s Degree
• 8+ years of academic and / or industry experience
• Or
• Master’s Degree
• 6+ years of academic and / or industry experience
• Or
• Ph.D. or equivalent advanced degree in the Life Sciences
• 4+ years of academic and / or industry experience

Preferred Qualifications

• M.S. or Ph.D. in immunology, molecular and cellular biology, or relevant discipline
• M.S. with 10+ years or Ph.D with 5+ years of experience, preferably in the biotechnology or pharmaceutical industry setting, or demonstrated deep experience in immunology or cell therapy academic research
• Expertise in immunology or cellular biology is required, knowledge of fundamentals of autoimmune and inflammatory diseases is desirable
• Familiarity with and experience in the drug development process from IND filing to market authorization in an industry setting is desirable
• Expertise in developing and analyzing biomarkers for clinical trials
• Experience analyzing high content (eg, transcriptomic, proteomic) datasets
• Excellent communication and interpersonal skills, evidenced by strong ability to interact with and influence research scientists, project teams, outside collaborators and commercial vendors
• Detail-oriented with the ability to identify and implement creative solutions
• Ability to prioritize and manage time efficiently

Compensation Overview

Seattle - WA: $152,360 - $184,628

The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits

Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).

U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.

Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.

Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.

U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits

How We Work

Where you work matters – because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https://careers.bms.com/ways-of-working.

Supporting People with Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [e-mail]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

For roles based in Los Angeles County only: If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If this posting is missing required information required by local law or incorrect, contact BMS at [e-mail] with the Job Title and Requisition number. Do not send application-related inquiries to this email. To check your application status, please login to your Candidate Home Account.