Principal Scientist, Analytical Sciences

Korro Bio, Inc.; Cambridge (MA); On-site; USD 160,000 - 190,000; Full time

Benefits offered by this job

Equity-based compensation

Medical, dental, and vision insurance

401(k) retirement plan

Life insurance

Health savings account

Job summary

Korro Bio, Inc., located in Cambridge, Massachusetts, is looking for an experienced professional in analytical chemistry. This role entails developing and optimizing methods for synthetic oligonucleotide therapeutics, ensuring compliance with cGMP standards, and collaborating with various teams. A PhD with relevant experience is necessary, alongside strong analytical skills and communication.

The compensation package includes a salary range of $160,000 – $190,000, plus bonuses and a comprehensive benefits plan that covers health insurance, retirement savings, and more.

Qualifications

• PhD with 3+ years or MS with 7+ years in analytical chemistry.
• Hands-on experience in analytical method development for small molecules.
• Expertise in chromatographic and spectroscopic techniques.

Responsibilities

• Develop and optimize analytical methods for drug products.
• Ensure compliance with cGMP standards during method validation.
• Analyze complex data and present to cross-functional teams.

Skills

Analytical method development

Chromatographic techniques

Spectroscopic techniques

cGMP compliance

Data analysis and presentation

Education

PhD in Analytical Chemistry

MS in related field

BS in relevant field

Tools

LC-UV

LC-MS

UV-Vis

Job description

Company Summary

Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform. Korro is generating a portfolio of differentiated programs that harness the body’s natural RNA editing process to effect a precise yet transient single base edit. By editing RNA instead of DNA, Korro expands the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary platform with precedented delivery modalities, manufacturing know-how, and established regulatory pathways of approved oligonucleotide drugs. Korro is based in Cambridge, Massachusetts.

We are collaborative and united by a common mission. We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases. Our values — Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity — form the fabric of the organization. They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work. Join us as we redefine what’s possible in genetic medicine and work to make a lasting impact on human health.

Key Responsibilities

• Serve as SME for synthetic oligonucleotide-based drug substance and drug product release and characterization assays. Develop and optimize analytical methods as needed.
• Support analytical method validation, transfer, and troubleshooting to ensure compliance with cGMP standards.
• Collaborate with the Process/Formulation Development teams to ensure seamless integration of analytical methods into DS and DP manufacturing workflows.
• Analyze, interpret, and present complex data to cross‑functional teams and senior management.
• Author and review technical reports, protocols, SOPs, and sections of regulatory filings (IND, IMPD, etc.).
• Assist in managing external analytical collaborations with CROs and CMOs, ensuring data quality and timelines are met.
• Stay current with emerging analytical technologies and apply innovative solutions to improve method robustness and efficiency.
• Support investigations and root cause analyses for any out‑of‑specification (OOS) results, deviations, or process failures.

Required Qualifications

• PhD in Analytical, Organic Chemistry, or related field with 3+ years’ experience; or MS with 7+ years; or BS with 10+ years of relevant industry experience.
• 3+ years of hands‑on experience in analytical method development for small molecule therapeutics. Experience in synthetic oligonucleotide therapeutics is desired.
• Expertise in chromatographic (e.g., LC‑UV, LC‑MS) and spectroscopic techniques (e.g., UV‑Vis), with a strong understanding of method validation requirements.
• Experience with compendial methods used to release sterile products and compendial method verification.
• Familiarity with HRMS analysis in the identification of DS impurities.
• Functional knowledge of the chemical principles of molecular degradation pathways.
• Strong understanding of cGMP and ICH guidelines for analytical aspects of small molecule sterile products in clinical development.
• Experience with supporting design and management of stability studies.
• Expertise with managing primary and working reference standard qualification, aliquoting, and long‑term management across all end users of the material.
• Managed transfer, qualification, and ideally validation of methods.
• Supported batch disposition, OOS, OOT, and investigations.
• Excellent written and verbal communication skills, with experience drafting technical reports and regulatory documents.
• Ability to work collaboratively in a fast‑paced environment and manage multiple projects simultaneously.

Salary

$160,000 – $190,000 a year (base salary, plus potential annual bonus and equity awards).

Benefits

Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending account, a Company‑funded health savings account, and free parking.

EEO Statement

We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, pregnancy, gender identity, sexual orientation, age, disability, or any other protected characteristic.