Principal Scientist 1 - Chemical Research & Development

Cambrex Corp.; High Point (NC); Presencial; USD 120.000 - 180.000; Jornada completa

Descripción de la vacante

Cambrex Corp. is seeking a Principal Scientist 1 in Chemical Research and Development in North Carolina to optimize existing chemical routes and develop alternative chemistries toward APIs. You will perform multistep synthesis, purification, and analytical evaluation in a collaborative lab setting and communicate findings in client meetings and R&D reports.

The role requires a Ph.D. in Chemistry (or MS with extensive experience) and a track record in pharmaceutical process development, alongside

Formación

• Ph.D. in Chemistry or related field with extensive lab experience.
• Hands-on pharmaceutical process development experience preferred.
• Strong written and verbal communication; ability to work in a diverse team.

Responsabilidades

• Design and carry out multistep organic syntheses, isolation, and purification of targeted products.
• Understand modern organic synthesis methodologies and analytical data interpretation.
• Coordinate with clients and internal teams; prepare technical reports and project updates.
• Lead investigations, provide mentorship, and drive process improvements.
• Coordinate equipment and activities with GMP operations and manufacturing groups.
• Maintain safe, compliant laboratory practices and well-documented records.

Conocimientos

Organic Chemistry

Cross Discipline

GMP/Regulatory

Instrumentation

Communication

Problem Solving

Time Management

Leadership

Documentation

External Influence

Industry Credibility

Operational Excellence

Change Orientation

Educación

PhD in Chemistry

MS in Chemistry

BS in Chemistry

Descripción del empleo

Company Information

You Matter to Cambrex.

Cambrex is a leading global contract development and manufacturing organization (CDMO) that provides drug substance, drug product, and analytical services across the entire drug lifecycle. With more than 40 years of experience and a growing team of over 2,000 professionals servicing global clients, Cambrex is a trusted partner in branded and generic markets for API and dosage form development and manufacturing.

Your Work Matters.

At Cambrex, we strive to build a culture where all colleagues have the opportunity to:

• engage in work that matters to our customers and the patients they serve
• learn new skills and enjoy new experiences in an engaging and safe environment
• strengthen connections with coworkers and the community

We’re committed to attracting and nurturing a passionate team of valued professionals in our fast-paced and growing company. We offer a competitive benefits package that includes healthcare, life insurance, planning for retirement, and more!

Your Future Matters.

Known for our customer-focused scientific and manufacturing excellence, as well as our strong commitment to quality and safety, we offer a range of career and growth opportunities across our global network of locations. Together with our customers, we aim to improve the quality of life for patients around the world.

Job Overview

The Principal Scientist 1 - Chemical Research and Development role is directed toward optimization of existing chemical routes and development of alternate chemistry toward key synthetic intermediates and APIs. Carries out multistep chemical synthesis and product isolation/purification operations in the laboratory, independently or as part of an integrated team. Chemist utilizes modern analytical tools to determine identity and purity of products made during projects. Communication with clients in regular team meetings; prepares R & D reports at the conclusion of projects.

Responsibilities

• Design and carry out multistep organic syntheses, isolation, and purification of targeted products.
• Must possess a strong understanding of modern organic synthesis methodologies.
• Must have a thorough understanding of modern analytical and spectroscopic techniques and be able to interpret the corresponding data and spectra.
• Ability to conduct literature searches for specific target compounds and be able to use the literature to base a design of alternate routes to these compounds. Requires ongoing professional development to keep abreast of current scientific literature and discuss these findings with colleagues.
• Must demonstrate a proficiency to carry out laboratory syntheses and purification techniques on scales ranging from milligrams to several kilograms, and design and implement process modifications.
• Requires excellent time management with the ability to manage projects on-time without supervision.
• Ability to author and review comprehensive reports at the conclusion of projects for internal and customer use.
• Work closely with other chemistry and analytical laboratory staff to coordinate project activities and resource usage.
• Work to ensure that a spirit of teamwork and cooperation always exists within the group.
• Conduct laboratory operations in a safe manner. Maintain familiarity with the company’s chemical hygiene plan. Exhibit safety awareness and safe work practices.
• Follow responsible actions regarding chemical disposal. Maintain compliance with all regulations at the federal, state, and local levels.
• Must demonstrate effective communication skills (both interpersonal and presentations). Participate in project team meetings with customers.
• Work closely with manufacturing and GMP operations to coordinate project related equipment and activities.
• Maintain a clean, safe laboratory work area.

Qualifications / Skills

Organic Chemistry Knowledge: Beginning to demonstrate an understanding of advanced theories in Organic Chemistry/Process Development.

Cross Discipline Knowledge: Higher level of understanding of the principles of cross-functional departments, including analytical chemistry and engineering.

GMP/Regulatory Knowledge: Demonstrated understanding of the GMP landscape and fundamental understanding of the industrial regulatory landscape; Good understanding of site SOPs and regulatory CMC concerns and can answer client questions that can help to develop their clinical package.

Instrumentation: Advanced knowledge of HPLC, GC, MS, automated reactor platforms, In-situ reactionmonitoring, and ability to train and troubleshoot problems with equipment (and help others).

Communication: Good written and oral communication skills, often leading technical calls with clients.

Problem Solving: Strond demonstration of problem solving, ability to lead investigations.

Time Management: Able to maintain timeline of key activities and use time efficiently; ability to handle projects without supervision, though requires regular check-in with manager.

Leadership: Demonstrated record of mentorship and development of peers, partner lines and ability to supportinitiatives within the department.

Technical Documentation and Review: Ability author and review technical documents with minimal RFT errors. Can write new SOP with manager assistance, keep current lab notebook while practicing GDP.

External Influence: Ability to lead local project teams and steer clients to desired outcomes; ability to work with management to develop key local laboratory-based initiatives.

Industry Credibility and Rapport: Recognized scientific leader within the Cambrex organization, locally and possibly beginning to extend to other sites.

Operational Excellence: Actively participates in key operational excellence initiatives.

Change Orientation: Active participation and support for implementation of Cambrex system level changes/initiative.

Education, Experience & Licensing Requirements

Ph.D. in Chemistry or related field with minimum 6 years’ experience or M.S. in Chemistry or related field with minimum 10 years’ experience or B.S. degree in Chemistry or related field with 12 years of experience in lab environment, pharmaceutical experience preferred. Hands on experience in pharmaceutical/chemical process development. Excellent verbal and written communication/interpersonal skills, organizational skills, and the ability to work in a diverse team environment are essential. Proficiency with Microsoft software (SharePoint, Word / EXCEL / PowerPoint), and Chemdraw is expected.

Some active work, exerting up to 50 pounds of force occasionally, and/or the amount of force frequently or constantly to lift, carry, push, pull or otherwise move objects. The daily work is performed is primarily in a laboratory setting. Walking and standing are required regularly.

Position also requires visual acuity, talking and fingering.

Involves regular use of basic PPE (personal protective equipment) such as supplied air respirator, negative pressure respirator, gloves, safety glasses, shielding clothing.

All requirements are subject to possible modifications to reasonably accommodate individuals with disabilities. Cambrex Corporation is an Equal Opportunity / Affirmative Action employer and will consider all qualified applicants for employment without regard to race, color, religion, sex (including pregnancy, sexual orientation, or gender identity), ancestry, national origin, place of birth, age, marital status, disability/handicap, genetic information, veteran status, or other characteristics protected by federal, state, and/or local law.