Principal Safety Scientist - SERM

GlaxoSmithKline; Philadelphia (Philadelphia County); On-site; USD 140,000 - 220,000; Full time

Job summary

GlaxoSmithKline seeks a Medical/Scientific Safety professional to provide pharmacovigilance expertise in safety assessments for clinical development and post-marketing products.

The role includes leading signal detection, generating safety evaluations, and contributing to risk management plans with senior colleagues. Strong cross-functional collaboration and clear risk communication are essential.

Qualifications

• Degree in a health or life sciences discipline or healthcare professional qualification (e.g., PharmD, PhD, RN, RPh, BSc) or equivalent experience.
• Experience in pharmacovigilance, safety evaluation, clinical safety or a related role in pharma/biotech.
• Practical knowledge of safety evaluation methods, signal detection principles and adverse event reporting.
• Experience with clinical development and post-marketing safety activities.

Responsibilities

• Leads signal detection and evaluation for assigned products.
• Produces clear, accurate safety evaluations for internal/regulatory requests.
• Contributes to Risk Management Plans and safety documentation.
• Authors and reviews global periodic safety reports, aggregate reports, protocols.
• Participates in audit/inspection follow-up activities.
• Collaborates with SERM physicians to investigate safety issues.

Skills

Digital Fluency

Enterprise Leadership

Influencing Without Authority

Pharmacovigilance

Presentation Techniques

Education

Degree in health or life sciences

Advanced medical or scientific degree

Tools

Safety databases

Signal detection tools

Job description

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people's lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success. We're uniting science, technology, and talent to get ahead of disease together.

Find out more: Our approach to R&D

We are looking for this role to be based in the UK, Poland or Brazil.

For candidates seeking to be located at our Stevenage site, this role will temporarily be based at Stevenage. However, the Company plans to relocate its offices to Cambridge, UK. The location of this role will therefore subsequently change to Cambridge, UK in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029

Job Purpose

• Provides medical/scientific knowledge in the safety evaluation and risk management of GSK products in clinical development and/or the post-marketing setting.
• Ensures scientifically sound review and interpretation of data and management of safety issues and escalates safety issues identified through the safety review process to senior management and safety governance as appropriate. Makes recommendations for the further characterization, management, and communication of safety risks.
• Focus on efficiency and effectiveness to meet the needs of our Patients and HCPs. Supporting the pharmacovigilance and benefit-risk management of the assigned portfolio of GSK global assets to ensure Patient Safety globally.
• If appointed as a manager (i.e., Team/Group Leader) is responsible for leadership of a team of individual contributors. Line Management (including functional matrix reports) leadership competencies include resource and team management, coaching, influencing others, collaborative working, decision making, change management, partnership, and relations management.

In this role you will...

• Scientific/Medical Knowledge & PV Expertise
• Leads signal detection and evaluation activities for assigned products.
• Produces clear, accurate, and fit-for-purpose safety evaluations in response to internal and regulatory requests.
• Contributes to Risk Management Plans (RMPs), risk assessments, and safety documentation in collaboration with senior colleagues.
• Authors and reviews global periodic safety reports, aggregate reports, protocols, and other regulatory documents within agreed timelines.
• Participates in process improvement initiatives and ensures timely completion of audit and inspection follow-up activities.
• Utilizes multiple data sources to investigate safety issues, propose solutions, and support decision-making in consultation with SERM physicians.
• Effectively prioritizes workload, manages competing deadlines, and consistently delivers high-quality outputs with minimal supervision.
• 2. Cross-Functional Matrix Leadership
• Builds strong collaborative relationships across functions to address product safety matters.
• Supports Safety Review Teams (SRTs) and governance activities in both development and post-marketing settings, helping to identify, evaluate, and mitigate safety risks.
• Contributes to the implementation of risk minimization strategies in clinical protocols and product labeling.

• 3. Communication & Influencing
• Demonstrates strong verbal, written, and medical/scientific communication skills, producing high-quality evaluations and reports.
• Supports and communicates safety risk positions clearly to internal and external stakeholders.

Why You?

Basic Qualification

• Degree in a health or life sciences discipline or healthcare professional qualification (for example, PharmD, PhD, RN, RPh, BSc) or equivalent experience.
• Experience in pharmacovigilance, safety evaluation, clinical safety or a related role in the pharmaceutical or biotech industry.
• Practical knowledge of safety evaluation methods, signal detection principles and adverse event reporting.
• Experience with clinical development and post-marketing safety activities.
• Good clinical and scientific literacy, including understanding of medical terminology and study design.

Preferred Qualification

• Advanced medical or scientific degree (for example, PhD, MSc) or clinical training.
• Experience authoring or contributing to regulatory safety documents and risk management plans.
• Experience working across global teams and multi-country safety requirements.
• Familiarity with pharmacovigilance regulations and guidance in global regions.
• Experience with safety databases and safety signal detection tools.

Closing Date: Monday 5th October 2026

Skills

Digital Fluency, Enterprise Leadership, Influencing Without Authority, Pharmacovigilance, Presentation TechniquesPolish Salary Range / Polski przedzia wynagrodzenia: PLN 215,250 to PLN 358,750The annual gross base salary range for new hires in this position is listed above for each applicable location. These ranges take into account a number of factors including the candidate's skills, experience, education level and the market rate for the role. In addition, this position may offer an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. More detailed information on the total benefits package will be supplied during the recruitment process. This role is available for applicants from multiple locations, and therefore salary ranges for certain locations are also shown. Salary ranges for other locations are shown because some markets have pay transparency laws that require salary information on job postings, and those locations are potential job sites for this role. If salary ranges are not displayed in the job posting for a specific location or country, the relevant compensation will be discussed during the recruitment process. Please note salaries vary by country based on the candidate's skills, experience, education level and the market rate for the role. Offers are typically made within the advertised range based on the candidate's skills, experience and qualifications, with the upper end generally reserved for highly experienced candidates or other exceptional circumstances aligned with these criteria.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive.

We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at [e-mail] where you can also request a call.

Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a Recruitment FAQ guide. Click the Link where you will find answers to multiple questions we receive

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