Principal Research Scientist I/II, CMC Purification Development

BioSpace; South San Francisco (CA); On-site; USD 90,000 - 150,000; Full time

Job summary

An established industry player is seeking a Principal Research Scientist to lead the purification process development for biologics in a dynamic and collaborative environment. This full-time role emphasizes the development of robust processes for drug substance GMP production, supporting clinical studies and licensure. The ideal candidate will possess expertise in monoclonal antibody purification, chromatography, and strong communication skills. Join a team dedicated to innovation in the biologics sector, where your contributions will directly impact the advancement of critical therapies.

Benefits

Competitive benefits

Onsite role

Mentorship opportunities

Collaborative environment

Qualifications

• Lead purification process development for biologics with a focus on GMP production.
• Expertise in monoclonal antibody purification and chromatography techniques.

Responsibilities

• Optimize purification processes and manage project deliverables.
• Mentor team members and contribute to regulatory filings.

Skills

Monoclonal antibody purification

Chromatography

Communication

Scientific publication

Education

Bachelor's in Chemical Engineering

Master's in Bioengineering

PhD in Related Field

Tools

AKTA systems

HPLC

ELISA

Mass spectrometry

Job description

Principal Research Scientist I/II, CMC Purification Development

Join to apply for the Principal Research Scientist I/II, CMC Purification Development role at BioSpace

Job Description

The Biologics CMC Development team at AbbVie in the Bay Area is seeking a Principal Research Scientist to lead purification process development for biologics. This onsite role involves developing robust, phase-appropriate processes for drug substance GMP production, supporting clinical studies and licensure. Responsibilities include leading development, optimization, and scale-up of purification processes, contributing to development strategies, and collaborating across teams.

Responsibilities

• Lead purification process development and optimization for biologics
• Generate and evaluate scientific proposals and novel separation technologies
• Manage purification strategies and project deliverables
• Transfer processes to GMP manufacturing and work with contract labs
• Mentor team members and contribute to scientific publications and regulatory filings

Qualifications

Basic:

• Bachelor's, Master's, or PhD in chemical engineering, bioengineering, or related field with relevant experience
• Expertise in monoclonal antibody purification and chromatography
• Proficiency with AKTA systems and virus clearance studies
• Strong communication and scientific publication record

Preferred:

• Experience with analytical techniques such as HPLC, ELISA, mass spectrometry
• Knowledge of chromatography modeling and process automation

Additional Information

This is a full-time, onsite position in South San Francisco with competitive benefits. Compensation will depend on experience and location.

Other Details

Level: Mid-Senior; Industry: Biologics/CMC; Location: South San Francisco, CA