Principal Program Manager, Enterprise Integration

McKesson Corporation; Columbus (OH); On-site; USD 170,000 - 284,000; Full time

Job summary

McKesson Corporation in Columbus, OH seeks a Principal Program Manager, Enterprise Integration to lead large-scale transformation across the technology ecosystem, including cloud migration, middleware modernization, and integration platforms.

This role partners with executives and architecture teams to deliver program roadmaps, governance, and value realization, while managing budgets, risks, and external vendors.

Qualifications

• 13+ years of IT program management, enterprise transformation, or technology portfolio leadership.
• Bachelor's degree in Information Technology, Computer Science, Engineering, Information Systems, Business, or related field.
• Experience with MuleSoft, IBM MQ, IBM MFT, SAP BODS, Azure, and cloud/API platforms.
• Experience leading large-scale enterprise transformation programs with executive visibility.
• Proven cross-functional portfolio management across architecture, engineering, operations, security, and stakeholders.
• Experience managing budgets, forecasts, and portfolio investments.
• Experience with enterprise integration technologies, middleware, APIs, and cloud migration.
• Experience overseeing external partners and vendors.
• Strong executive communication, governance, and risk management.
• Experience supporting ITGC, SOX, HIPAA, DSCSA or similar regulations.
• Experience developing business cases and ROI analyses.
• Vendor relationship management experience.

Responsibilities

• Lead enterprise-wide integration and modernization programs from strategy to execution, on time and on budget.
• Drive transformation initiatives: MuleSoft, middleware modernization, cloud migration, MFT/MQ upgrades.
• Develop multi-year roadmaps, dependencies, risks, and delivery metrics across orgs.
• Establish governance and exec reporting on health, outcomes, value, and priorities.
• Lead vendor and managed services relationships, including KPI tracking and SOW governance.
• Drive TCO optimization through lifecycle planning, licensing, and negotiations.
• Collaborate with EARB, security, compliance, and audit to meet enterprise standards.
• Align senior leaders across Enterprise & Corporate groups to achieve business goals.

Skills

Executive communication

Stakeholder management

Governance

Risk management

Budgeting & forecasting

Portfolio leadership

Enterprise integration

Cloud migration

Vendor management

ITGC/SOX/HIPAA compliance

Education

Bachelor's degree in IT/CS/Engineering/IS/Business

Tools

MuleSoft

IBM MQ

IBM MFT

SAP BODS

Azure

GCP

API integration platforms

Boomi

Enterprise middleware

Job description

Principal Program Manager, Enterprise Integration

McKesson is an impact-driven, Fortune 10 company that touches virtually every aspect of healthcare. We are known for delivering insights, products, and services that make quality care more accessible and affordable. Here, we focus on the health, happiness, and well-being of you and those we serve - we care.

What you do at McKesson matters. We foster a culture where you can grow, make an impact, and are empowered to bring new ideas. Together, we thrive as we shape the future of health for patients, our communities, and our people. If you want to be part of tomorrow's health today, we want to hear from you.

McKesson is seeking a strategic and results-driven Principal, Program Manager, Enterprise Integration to lead large-scale enterprise integration, modernization, and transformation initiatives across our technology ecosystem. This role oversees highly complex, cross-functional programs spanning cloud migration, application integration, managed file transfer, middleware modernization, and enterprise platform strategy.

You will partner with technology executives, business leaders, architecture teams, and strategic partners to deliver critical transformation programs that enable business growth, operational excellence, regulatory compliance, and long-term platform optimization. You will be responsible for portfolio governance, financial stewardship, modernization roadmaps, and executive alignment across multiple business units.

What You'll Do

• Lead enterprise-wide, cross-functional integration and modernization programs from strategy through execution, ensuring on-time, on-budget, and high-quality delivery.
• Drive major transformation initiatives, including MuleSoft platform evolution, middleware modernization, cloud migration programs, IBM MFT/MQ modernization, SAP BODS upgrades, and Integration-as-a-Service strategies.
• Develop and manage multi-year program roadmaps, dependencies, risks, and delivery metrics across multiple technology and business organizations.
• Establish portfolio governance and executive reporting frameworks that provide visibility into program health, outcomes, value realization, and investment priorities.
• Lead strategic vendor and managed services relationships, including performance management, capacity planning, SOW governance, KPI tracking, and resource optimization.
• Drive platform rationalization and Total Cost of Ownership (TCO) optimization through technology lifecycle planning, licensing strategy, and vendor negotiations.
• Partner with Enterprise Architecture Review Board (EARB), security, compliance, and audit teams to ensure adherence to enterprise standards and regulatory requirements.
• Align senior stakeholders across Enterprise & Corporate, NAPD, MMS, CMM, and Technology leadership organizations to achieve strategic business objectives.

Basic Requirements

• 13+ years of experience in IT program management, enterprise transformation, integration platforms, cloud migration, or technology portfolio leadership.
• Bachelor's degree in Information Technology, Computer Science, Engineering, Information Systems, Business, or a related field, or equivalent experience.
• Experience with MuleSoft, IBM MQ, IBM MFT, SAP BODS, Azure, GCP, API integration platforms, or enterprise middleware technologies.
• Experience leading large-scale, enterprise-wide technology transformation programs with executive-level visibility.
• Proven experience managing complex cross-functional portfolios involving architecture, engineering, operations, security, and business stakeholders.
• Experience managing budgets, forecasts, financial planning, and portfolio investment decisions.
• Experience working with enterprise integration technologies, middleware platforms, APIs, cloud migration initiatives, or application modernization programs.
• Demonstrated experience overseeing external partners, managed service providers, or strategic technology vendors.
• Strong executive communication, stakeholder management, governance, and risk management capabilities.
• Experience supporting compliance and audit requirements including ITGC, SOX, HIPAA, DSCSA, or similar regulatory frameworks.
• Experience developing business cases, ROI analyses, and TCO-based investment recommendations.
• Strong experience managing vendor relationships.

Preferred Skills/Experience

• Strong experience working with the Boomi platform
• Experience leading cloud migration and modernization programs in highly regulated environments.
• Knowledge of enterprise architecture governance and EARB processes.
• Strong understanding of platform operating models, capacity planning, resource management, and technology portfolio governance.
• PMP, PgMP, SAFe, Agile, ITIL, or comparable program management certifications.
• Experience leading geographically distributed teams and large-scale managed services engagements.

We are proud to offer a competitive compensation package at McKesson as part of our Total Rewards. This is determined by several factors, including performance, experience and skills, equity, regular job market evaluations, and geographical markets. The pay range shown below is aligned with McKesson's pay philosophy, and pay will always be compliant with any applicable regulations. In addition to base pay, other compensation, such as an annual bonus or long-term incentive opportunities may be offered. For more information regarding benefits at McKesson,

Our Base Pay Range for this position

$170,100 - $283,500

McKesson provides equal employment opportunities to applicants and employees, without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, age, genetic information, or any other legally protected category. For additional information on McKesson's full Equal Employment Opportunity policies, visit our Equal Employment Opportunity page.

McKesson is committed to being an Equal Employment Opportunity Employer and offers opportunities to all job seekers including job seekers with disabilities. If you need a reasonable accommodation to assist with your job search or application for employment, please contact us by sending an email to (United States) [e-mail] or (Canada) [e-mail] . Resumes or CVs submitted to this email box will not be accepted.

Join us at McKesson!