Principal Process Engineer - Upstream/Downstream Lead

Amgen Inc. (IR); Holly Springs (NC); On-site; USD 140,000 - 190,000; Full time

Job summary

Amgen Inc. in the United States seeks a Principal Process Engineer for Upstream/Downstream to lead design, commissioning, and qualification of critical drug substance equipment. You will drive projects, ensure GMP compliance, and mentor the manufacturing engineering team.

The role requires strong leadership, broad engineering expertise, and ability to collaborate with cross-functional partners across Manufacturing, Quality, and Process Development. Travel up to 10% is possible.

Qualifications

• Leadership and project management experience.
• Strong communication, technical writing and presentation skills.
• Experience in biopharmaceutical manufacturing environments is a plus.

Responsibilities

• Design, build, commission, and qualify new equipment and systems for drug substance production.
• Lead technical projects and drive process improvements to meet GMP requirements.
• Provide mentorship to junior engineers and support 24/7 manufacturing operations.

Skills

Leadership

Project management

Technical writing

Communication skills

Education

Bachelor’s degree in Chemical or Mechanical Engineering

Job description

Amgen Inc. in the United States seeks a Principal Process Engineer for Upstream/Downstream to lead design, commissioning, and qualification of critical drug substance equipment. You will drive projects, ensure GMP compliance, and mentor the manufacturing engineering team.

The role requires strong leadership, broad engineering expertise, and ability to collaborate with cross-functional partners across Manufacturing, Quality, and Process Development. Travel up to 10% is possible.