Principal Process Engineer - Purification, Lilly Medicine Foundry

Scorpion Therapeutics; Indianapolis (IN); On-site; USD 66,000 - 172,000; Full time

Benefits offered by this job

Bonus eligible

Comprehensive benefits

Job summary

Scorpion Therapeutics is seeking a chemical engineer with 5+ years in API process engineering to support API manufacturing operations, including process knowledge, equipment support, and optimization. The role involves risk assessments, equipment qualification, and collaboration with multiple technical teams.

The successful candidate will mentor junior engineers, contribute to technical reports and regulatory submissions, and ensure adherence to cGMP and Quality System requirements.

Qualifications

• BS or MS in chemical engineering (or related) and at least 5 years in pharma/biotech/CMO supporting API process engineering/manufacturing or development.

Responsibilities

• Provide technical assessment/support for API manufacturing operations (oligonucleotides, peptides, bioconjugates) including process knowledge, equipment/process support, optimization, asset management.
• Perform impact/risk assessments for purification equipment/units (e.g., chromatography skids/columns, TFF skids).
• Drive purification equipment design and qualification documentation; represent process engineering in Facility Acceptance Testing.

Skills

Chemical engineering expertise

5+ years API process engineering

US work authorization

Education

BS or MS in chemical engineering

Tools

DeltaV

Rockwell

OSI-PI

Dynochem

ELN

Job description

Responsibilities

• Provide technical assessment/support for API manufacturing operations (oligonucleotides, peptides, bioconjugates) including process knowledge, equipment/process support, optimization, equipment capability/asset management, and engineering business systems.
• Perform impact/risk assessments for purification equipment/unit operations (e.g., chromatography skids/columns, TFF skids).
• Drive purification equipment design and qualification documentation; represent process engineering in Facility Acceptance Testing.
• Conduct equipment walkdowns during commissioning/qualification; troubleshoot and provide paths forward.
• Guide automation recipe/procedure discussions for correct equipment operation.
• Mentor junior engineers; author/review/approve technical reports and regulatory submissions; maintain records/technical notebooks.
• Ensure safety-first mindset and compliance with Quality System requirements and cGMP.
• Assess rig fit via data package review plus modeling/simulations/experiments for scale-up (heat/mass transfer).
• Coordinate with HSE, Quality Assurance, Tech Services, Development, Operations, FUME/C&Q, Automation, Maintenance, Environmental Monitoring, and Manufacturing.

Basic Requirements

• BS or MS in chemical engineering (or related) and at least 5 years in pharmaceutical/biotech/CMO supporting API process engineering/manufacturing or development.
• Full-time U.S. work authorization (Lilly does not sponsor visas/work authorization).

Additional Preferences

• Experience with unit operations/equipment & control strategies (e.g., chromatography types, TFF, distillation, lyophilization, enzymatic ligation); GMP troubleshooting/root-cause analysis.
• Software experience (DeltaV preferred; Rockwell, OSI-PI, Dynochem, Aspen, electronic lab notebooks).
• Strong analytical/problem-solving and communication skills; process control understanding; initiative; mentoring.

Other Info / Benefits

• Location: initial at Lilly Technology Center (Indianapolis); permanent at Lilly Medicines Foundry (Lebanon, IN).
• Anticipated wage: $66,000–$171,600; bonus eligible; comprehensive benefits (401(k), medical/dental/vision, life insurance, time off/leave, wellness).