Principal PK Scientist: Translational Pharmacology

U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.; Cambridge (MA); Hybrid; USD 109,000 - 202,000; Full time

Benefits offered by this job

Health, life and disability benefits

401(k) with company contribution and a

Generous time off

Job summary

Novartis Institutes for BioMedical Research, Inc. is seeking a PK Sciences project team representative to develop and implement translational pharmacology strategies across late clinical development.

The role spans PK, ADME, M&S, and clinical pharmacology to inform dose selection and study design in diverse modalities including small molecules, biologics, ADCs, radioligands, and cell therapies. The position emphasizes cross-functional collaboration, regulatory interaction, and applying AI/ML to

Qualifications

• Ph.D. or Pharm.D. with relevant experience in clinical pharmacology, drug metabolism and pharmacokinetics.
• 0-2 years in drug discovery/development in academia, CRO, biotech or pharma.
• 2+ years in lead ADME/DMPK project strategy or related roles.
• Strong knowledge of PK/PD, regulatory sciences and cross-functional teamwork.
• Exposure to AI/ML approaches is a plus.

Responsibilities

• Represent the PK Sciences function in project teams and with stakeholders and regulators.
• Contribute to developing drug candidates across Research, Development and Commercial continuum.
• Explain PK/PD relationships and develop dosing strategies and predictions.
• Design and analyze PK/PKPD data to support discovery through late development.
• Prepare PK/clinical pharmacology sections of regulatory submissions and responses.
• Collaborate with clinicians to integrate PK insights into study design and decision making.
• Apply AI/ML for model-guided design, data automation and regulatory document generation.

Skills

Pharmacokinetics

Drug metabolism

Clinical pharmacology

AI/ML fluency

Education

Ph.D. / Pharm.D.

Job description

Novartis Institutes for BioMedical Research, Inc. is seeking a PK Sciences project team representative to develop and implement translational pharmacology strategies across late clinical development.

The role spans PK, ADME, M&S, and clinical pharmacology to inform dose selection and study design in diverse modalities including small molecules, biologics, ADCs, radioligands, and cell therapies. The position emphasizes cross-functional collaboration, regulatory interaction, and applying AI/ML to