Principal Materials Engineer (Combination Devices)

Medtronic; Mounds View (MN); On-site; USD 135,000 - 203,000; Full time

Benefits offered by this job

Health insurance

401(k) plan

Tuition assistance

Employee stock purchase plan

Job summary

Medtronic is seeking a Principal Materials Engineer in the Cardiac Rhythm Management (CRM) area within the Electrophysiology Therapies group. This role focuses on device-drug combination products, materials selection, and pharmacokinetics for advanced cardiac therapies.

You will help define product strategy, perform benchtop testing, and drive data-driven decisions, with responsibilities spanning development, validation, and regulatory support across GLP-preclinical studies and postmarket

Qualifications

• 7+ years of relevant experience with a bachelor’s degree in chemistry or materials science
• Experience with device-drug combination products and regulatory requirements
• Familiar with ICH, USP/EP, 21 CFR 211/212/820

Responsibilities

• Provide expertise in materials selection and processing for combination devices
• Coordinate lab work and data analysis to support decisions
• Support postmarket design changes and CAPA activities

Skills

Device-drug combo

GMP experience

Materials testing

Statistics/DoE

Pharmacokinetics

Education

Bachelor's degree

Advanced degree

Tools

ISO standards

Job description

We anticipate the application window for this opening will close on - 31 Aug 2026Careers that change lives start here. Medtronic is a global leader in healthcare technology with a Mission to alleviate pain, restore health, and extend life. Our 95,000 employees work across more than 150 countries to put patients first — developing innovative medical technologies that improve the lives of 72+ million patients each year. Your unique talents will help shape the future of healthcare while building a career grounded in purpose, growth, and impact.A Day in the LifeThe Electrophysiology Therapies (EPT) group is looking for their next Principal Materials Engineer within the Cardiac Rhythm Management (CRM) operating unit.EPT offers devices and therapies to treat abnormal heart rhythms, as well as cardiac diagnostic and monitoring solutions. This role will serve as an expert in combination devices by participating in technical activities for materials selection, processing, analysis, biostability, and process-property-performance relationships for medical devices. Additionally, this role will serve as a combination specialist with an emphasis on polymers and pharmacological applications, pharmacokinetics, and drug elution, informing current product strategy, product roadmap, and risk burndown.At Medtronic, we bring bold ideas forward with speed and decisiveness to put patients first in everything we do. In-person exchanges are invaluable to our work. We are working on-site 4 days per week as part of our commitment to fostering a culture of professional growth and cross-functional collaboration as we work together to engineer the extraordinary. This role will require less than 10% of travel to enhance collaboration and ensure successful completion of projects.In general, the following responsibilities apply for the Principal Materials Engineer (Combo Devices) role. This includes, but is not limited to the following:Provide expertise in the following business-critical skill sets:-Device-drug combination product support, development, and regulations-Device-drug combination product characterization test methodologiesBe familiar with pharmaceutical test method validation, procedures and associated analytical test requirementsBe familiar with regulatory requirements around bioavailability and bioequivalenceUtilize ICH, USP/EP, and 21CFR Part 211/212 and Part 820Utilize basic pharmacodynamics and pharmacokinetics principles (AUC, tmax, Cmax, t1/2)Coordinate and conduct laboratory work and data analysis to drive data-driven technical decisionsUtilize formulation development for combination productsDesign benchtop testing and preclinical studies; understand requirements for a GLP preclinical studySupport postmarket design changes, manufacturing support, operational troubleshooting, and CAPA supportIntegrate product development and characterization testing into quality system and design controls; Be familiar with Design Verification and Design Validation requirementsNice to Haves - Preferred RequirementsExpertise in materials with the ability to identify and develop testing methods, correlate material properties with product performance, and predict various failure modescGMP experienceE xperience supporting product scaleup and launchKnowledge of external standards, e.g., ICH, ASTM and ISO, and their use, limitations, and applicationsDemonstrated ability to apply skills and knowledge of technical/operational theories and principles to resolve real-world biomaterials challengesKnowledge of statistical methods and Design of Experiments (DoE) using Minitab, JMP, or other statistical softwareMust Have - Minimum Requirements7+ years of relevant experience with a bachelor’s degree OR 3+ years of relevant experience with an advanced degree in chemistry, material science, chemical engineering, polymer science, or related fieldFor Baccalaureate degrees earned outside of the United States, a degree that satisfies the requirements of 8 C.F.R. § 214.2(h)(4)(iii)(A) is required.Physical Job RequirementsThe above statements are intended to describe the general nature and level of work being performed by employees assigned to this position, but they are not an exhaustive list of all the required responsibilities and skills of this position.The physical demands described within the Responsibilities section of this job description are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. For Office Roles: While performing the duties of this job, the employee is regularly required to be independently mobile. The employee is also required to interact with a computer, and communicate with peers and co-workers. Contact your manager or local HR to understand the Work Conditions and Physical requirements that may be specific to each role.U.S. Work Authorization & SponsorshipAt Medtronic, we are committed to fostering an environment where employees can thrive and make a meaningful impact. In alignment with our enterprise-wide workforce planning approach, U.S. work authorization sponsorship (H-1B, TN, J, etc.) is offered exclusively for Principal-level roles and above, where specialized expertise aligns with long-term business needs. Roles below the Principal level require candidates to possess unrestricted U.S. work authorization at the time of hire and for the duration of employment.Recruitment Fraud AlertWe are aware of phishing scams targeting job seekers. Please keep the following in mind:Apply only through official Medtronic channels. All legitimate Medtronic recruiting communications come from approved Medtronic platforms and official @medtronic.com email addresses.Medtronic will never ask for payment or sensitive personal information (such as bank account or Social Security details) during early stages of the hiring process. Any such requests are not legitimate.If you receive a suspicious message claiming to be from Medtronic, do not respond, click links, or open attachments.If you have any questions, concerns regarding the authenticity of a communication alleged to have been made by or on behalf of Medtronic, please contact us immediately at [e-mail] .Benefits & CompensationMedtronic offers a competitive Salary and flexible Benefits PackageA commitment to our employees lives at the core of our values. We recognize their contributions. They share in the success they help to create. We offer a wide range of benefits, resources, and competitive compensation plans designed to support you at every career and life stage.Salary ranges for U.S (excl. PR) locations (USD):$135,200.00 - $202,800.00This position is eligible for a short-term incentive called the Medtronic Incentive Plan (MIP).The base salary range is applicable across the United States, excluding Puerto Rico and specific locations in California. The offered rate complies with federal and local regulations and may vary based on factors such as experience, certification/education, market conditions, and location. Compensation and benefits information pertains solely to candidates hired within the United States (local market compensation and benefits will apply for others).The following benefits and additional compensation are available to those regular employees who work 20+ hours per week: Health, Dental and vision insurance , Health Savings Account , Healthcare Flexible Spending Account , Life insurance, Long-term disability leave , Dependent daycare spending account , Tuition assistance/reimbursement , and Simple Steps (global well-being program).The following benefits and additional compensation are available to all regular employees: Incentive plans, 401(k) plan plus employer contribution and match , Short-term disability , Paid time off , Paid holidays , Employee Stock Purchase Plan , Employee Assistance Program , Non-qualified Retirement Plan Supplement (subject to IRS earning minimums) , and Capital Accumulation Plan (available to Vice Presidents and above, or subject to IRS earning minimums).Regular employees are those who are not temporary, such as interns. Temporary employees are eligible for paid sick time, as required under applicable state law, and the Employee Stock Purchase Plan. Please note some of the above benefits may not apply to workers in Puerto Rico.Further details are available at the link below:Medtronic benefits and compensation plansIt is the policy of Medtronic to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, Medtronic will provide reasonable accommodations for qualified individuals with disabilities.If you are applying to perform work for Medtronic, Inc. (“Medtronic”) in any position which will involve performing at least two (2) hours of work on average each week within the unincorporated areas of Los Angeles County, you can find here a list of all material job duties of the specific job position which Medtronic reasonably believes that criminal history may have a direct, adverse and negative relationship potentially resulting in the withdrawal of a conditional offer of employment. Medtronic will consider for employment qualified job applicants with arrest or conviction records in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act.