Principal Software Engineer, Full Stack

Lila Sciences; Cambridge (MA); On-site; USD 204,000 - 272,000; Full time

Job summary

A pioneering technology firm in Cambridge is seeking a full-stack senior software engineer to collaborate with lab scientists and engineers. The role emphasizes Python development, cloud services, and cross-functional teamwork. Candidates should have a degree in Computer Science and 4-8 years of experience in software development. The expected salary for this role ranges from $204,000 to $272,000 USD per year, with bonus potential and equity options.

Qualifications

• 4-8 years of experience writing software in a commercial setting.
• Hands-on experience with AWS, GCP, or Azure.
• Strong understanding of Kubernetes and containerization.

Responsibilities

• Design and build high-performance, secure, and well-documented code.
• Diagnose and optimize system bottlenecks for high availability.
• Work with ML researchers and engineers to integrate services.

Skills

Full Stack Development

AWS

Kubernetes

Problem Solving

Communication & Collaboration

Education

Bachelor’s or Master’s degree in Computer Science or related field

Tools

React

TypeScript

FastAPI

SQL/NoSQL

Terraform

GitHub Actions

Job description

Join us in shaping the future of science! We are seeking an experienced full-stack senior software engineer to join our software platform team, where you’ll collaborate with software engineers, lab scientists, and machine learning engineers to build cutting‑edge tools for automated scientific analysis and more. This role spans web services and data engineering, with a strong emphasis on Python development for scientific applications. If you thrive in a collaborative, fast‑paced environment and bring best practices in git, development workflows, and user‑centered design, we want to hear from you.

What You'll Be Building

• Design & Build Services and Front‑ends: Design and build high‑performance, secure, and well‑documented code that integrate with an ecosystem of existing services and apps.
• Performance & Reliability: Diagnose and optimize system bottlenecks, ensuring high availability and low‑latency performance across large‑scale workloads.
• Cloud & Infrastructure: Leverage AWS services, Kubernetes and modern DevOps practices to build and deploy production‑grade systems at scale.
• Cross‑Functional Collaboration: Work with ML researchers, engineers, and scientists to integrate data pipelines, APIs, and cloud infrastructure into scientific workflows and services.

What You’ll Need To Succeed

• Bachelor’s or Master’s degree in Computer Science, Engineering, or related field.
• 4‑8 years of experience writing software in a commercial setting.
• Full Stack Development: Experience developing web apps across the full stack (React, TypeScript, Monorepos like Nx, TailWind, FastAPI, SQL/NoSQL, Python, Pydantic)
• Cloud & DevOps Knowledge: Hands‑on experience with AWS, GCP, or Azure; strong understanding of Kubernetes and containerization, infrastructure‑as‑code (Terraform, CloudFormation), and CI/CD pipelines (GitHub Actions).
• Communication & Collaboration: Acute listening skills, and a proven track record of working cross‑functionally with scientists, data engineers, and product teams; able to explain complex ideas to diverse audiences.
• Problem Solving: Proven ability to take ownership of complex backend challenges, balancing trade‑offs between scalability, performance, and maintainability.

Bonus Points For

• Hands‑On with Latest AI Tools: Exposure to AI technologies such as Large Language Models (LLMs), Retrieval‑Augmented Generation (RAG), or agentic frameworks, as well as experience leveraging AI to improve development performance.
• Experience with ORMs: Experience with and web services for CRUD services (SQLModel, FastAPI, Django).
• Orchestration Systems: Experience with orchestrators tools (Airflow, Prefect, Temporal, Dagster).
• Familiarity with Python for Science: Familiarity with data science and ML libraries (pandas, numpy, scipy, jax, pytorch).
• Domain Background: Exposure to laboratory software or analytics for life sciences, material sciences, or related fields.
• Experience with laboratory devices, robotics, or hardware drivers.

About Lila

Lila Sciences is the world’s first scientific superintelligence platform and autonomous lab for life, chemistry, and materials science. We are pioneering a new age of boundless discovery by building the capabilities to apply AI to every aspect of the scientific method. We are introducing scientific superintelligence to solve humankind's greatest challenges, enabling scientists to bring forth solutions in human health, climate, and sustainability at a pace and scale never experienced before. Learn more about this mission at www.lila.ai

Compensation

We expect the base salary for this role to fall between $204,000-272,000 USD per year, along with bonus potential and generous early equity. The final offer will reflect your unique background, expertise, and impact.

A Note to Agencies

Lila Sciences does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Lila Sciences or its employees is strictly prohibited unless contacted directly by Lila Science’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Lila Sciences, and Lila Sciences will not owe any referral or other fees with respect thereto.

Seniority Level

Mid‑Senior level

Employment Type

Full‑time

Job Function

Engineering and Information Technology

Industries

Technology, Information and Internet

If this sounds like an environment you’d love to work in, even if you only have some of the experience listed below, we encourage you to apply.