Principal Enterprise Architect, Digital Solutions

McKesson; Irving, Northern (TX, KY); Hybrid; USD 187,000 - 312,000; Full time

Job summary

McKesson, a Fortune 10 company, seeks a Principal Enterprise Architect, Digital Solutions to lead enterprise architecture strategy for US Oncology Practices. You’ll align architecture with business goals, partner with executives, and drive secure, scalable digital initiatives across oncology platforms.

You will influence senior leaders, mentor teams, and shape governance as part of a broad, strategic technology agenda that supports patient care and operational excellence.

Qualifications

• 15+ years in enterprise architecture or engineering leadership roles.
• Expertise in cloud modernization, multi-tenant platforms, and large-scale system design.
• Strong integration architecture background with APIs and interoperability standards.
• Experience with data platforms, semantic layers, analytics, and governed access models.
• Familiarity with clinical systems and oncology digital workflows preferred.

Responsibilities

• Define and evolve the enterprise digital architecture vision, principles, and roadmaps aligned with business objectives.
• Provide architectural leadership for major digital initiatives, platform strategies, and transformation programs.
• Advise executives and senior leaders on technology trends, risks, and long-term architectural implications.
• Ensure digital solutions are secure, scalable, interoperable, and compliant with enterprise and regulatory standards.
• Establish and maintain reference architectures, patterns, and governance.
• Influence and mentor architects and technical leaders through thought leadership.

Skills

Enterprise architecture

Cloud modernization

Multi-tenant platforms

System design

APIs & interoperability

Data platforms & analytics

Clinical oncology familiarity

Job description

McKesson is an impact-driven, Fortune 10 company that touches virtually every aspect of healthcare. We are known for delivering insights, products, and services that make quality care more accessible and affordable. Here, we focus on the health, happiness, and well-being of you and those we serve – we care.

What you do at McKesson matters. We foster a culture where you can grow, make an impact, and are empowered to bring new ideas. Together, we thrive as we shape the future of health for patients, our communities, and our people. If you want to be part of tomorrow’s health today, we want to hear from you.

Role Summary

The Principal Enterprise Architect, Digital Solutions is a senior leader responsible for defining and advancing the enterprise digital architecture strategy that enables scalable, secure, and innovative digital solutions for US Oncology Practices. This role partners closely with executive leaders, business stakeholders, clinical teams, and technology teams to translate Practice strategy into cohesive architectural direction.

Key Role Success Metrics

• Unified enterprise architecture blueprint established and regularly updated as needed.
• Multi-year digital roadmap delivered and socialized, with regular updates as needed.
• Architecture governance adopted across teams.
• Modernization and interoperability improvements realized.

Key Responsibilities

• Define and evolve the enterprise digital architecture vision, principles, and roadmaps aligned with business objectives.
• Provide architectural leadership for major digital initiatives, platform strategies, and transformation programs.
• Advise executives and senior leaders on technology trends, risks, and long-term architectural implications.
• Ensure digital solutions are secure, scalable, interoperable, and compliant with enterprise and regulatory standards.
• Establish and maintain reference architectures, patterns, and governance.
• Influence and mentor architects and technical leaders through thought leadership.

Role Characteristics

• Enterprise-wide scope with significant strategic and technical influence.
• Operates effectively in highly complex and ambiguous environments.
• Combines deep technical expertise with business and strategic acumen.
• Recognized authority for digital architecture and cross-domain design decisions.

Required Qualifications

• 15+ years in enterprise architecture or engineering leadership roles.
• Expertise in cloud modernization, multi-tenant platforms, and large-scale system design.
• Strong integration architecture background with APIs and interoperability standards.
• Experience with data platforms, semantic layers, analytics, and governed access models.
• Familiarity with clinical systems and oncology digital workflows preferred.

Preferred Qualifications

• Experience in oncology, clinical operations, or life sciences.
• Certifications: TOGAF, AWS/Azure Architect.
• Experience applying AI/ML to enterprise digital solutions, defining AI platform standards, and familiarity with cloud-native AI services

Working Conditions

• Environment (Office, warehouse, etc.) – Normal office environment

Physical Requirements

(Lifting, standing, etc.) – Normal office environment requirements

Travel

• Up to 25% travel required

Our Base Pay Range for this position

$187,400 - $312,400

We are proud to offer a competitive compensation package at McKesson as part of our Total Rewards. This is determined by several factors, including performance, experience and skills, equity, regular job market evaluations, and geographical markets. The pay range shown below is aligned with McKesson's pay philosophy, and pay will always be compliant with any applicable regulations. In addition to base pay, other compensation, such as an annual bonus or long-term incentive opportunities may be offered. For more information regarding benefits at McKesson, please click here.

McKesson is an Equal Opportunity Employer

McKesson provides equal employment opportunities to applicants and employees, without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, age, genetic information, or any other legally protected category. For additional information on McKesson’s full Equal Employment Opportunity policies, visit our Equal Employment Opportunity page.

McKesson is committed to being an Equal Employment Opportunity Employer and offers opportunities to all job seekers including job seekers with disabilities. If you need a reasonable accommodation to assist with your job search or application for employment, please contact us by sending an email to (United States) [e-mail] or (Canada) [e-mail]. Resumes or CVs submitted to this email box will not be accepted.

Join us at McKesson!