Principal Data Scientist – DDSAI GD

6084-Janssen Research & Development, LLC Legal Entity; Titusville (NJ); Hybrid; USD 117,000 - 201,000; Full time

Job summary

Johnson & Johnson Innovative Medicine seeks a Principal Data Scientist to lead end-to-end analytical solutions for clinical-development and trial-operations problems. You will own solution definition, delivery, adoption, and outcomes across stakeholder groups using ML, GenAI, optimization, and RWD.

Lead data science projects, manage stakeholder expectations, and collaborate with clinical, operational, and data teams to drive measurable use-case outcomes.

Qualifications

• Requires 5+ years leading end-to-end data-science solutions.
• Proficient in Python/SQL, ML, GenAI, NLP, and RWD analytics.
• Experience with multimodal data and time-series modeling.

Responsibilities

• Define end-to-end data-science solutions for business problems.
• Lead predictive modeling, simulations, optimization, and GenAI applications.
• Oversee data integration from EHR, claims, registries, and trial data.
• Mentor junior colleagues and contribute reusable code and patterns.

Skills

Advanced analytics

Data science

GenAI

ML

RWD analytics

Education

Master's degree in CS/engineering/biostatistics or quantitative field

PhD preferred

Tools

Python

SQL

Job description

Job Function:

Data Analytics & Computational Sciences

Job Sub Function:

Data Science

Job Category:

Scientific/Technology

All Job Posting Locations:

Titusville, New Jersey, United States of America

Job Description:

About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine

Job Summary:

J&J Innovative Medicine – Data, Data Science, and AI - Global Development (DDSAI GD) is seeking a Principal Data Scientist to lead end-to-end delivery of integrated analytical solutions for defined clinical-development and trial-operations business problems. This role owns solution definition, delivery, adoption, and use-case outcomes across connected stakeholder groups using ML, GenAI, optimization, and RWD.

Key Responsibilities

Own the end-to-end definition, development, validation, deployment, and adoption of integrated data-science solutions for defined business problems. Lead predictive modeling, simulations, optimization, and GenAI applications for study feasibility, enrollment forecasting, country and site selection, protocol design, and operational planning. Apply clinical, operational, cost, and RWD—including EHR, claims, registries, and clinical-trial data—to generate evidence on patient populations, treatment pathways, feasibility, and operational risks. Lead RWD analytics that inform protocol feasibility, eligibility criteria, recruitment and retention, study design, comparative evidence, and external-control use cases. Develop LLM-enabled workflows for information extraction, protocol comparison, data harmonization, clinical-concept interpretation, and targeted workflow automation. Partner with clinical, operational, technology, and data stakeholders to frame questions, manage trade-offs, and translate outputs into adopted recommendations and measurable use‑case outcomes. Apply model‑validation, MLOps, documentation, privacy, data‑quality, and responsible‑AI standards; contribute reusable code, data assets, and technical patterns. Communicate methods, model outputs, assumptions, limitations, and decisions clearly to technical and nontechnical audiences. Mentor junior colleagues and strengthen delivery practices across project teams.

Required Qualifications

Master’s degree in computer science, engineering, biostatistics, health economics, biomedical informatics, applied mathematics, or another quantitative discipline; PhD preferred. At least 5 years of industry experience leading end-to-end delivery of data‑science solutions using ML, predictive modeling, optimization, NLP, GenAI, or RWD analytics. Demonstrated experience defining, validating, deploying, and driving adoption of analytical solutions that inform clinical-development, clinical-operations, or real-world evidence decisions. Hands‑on experience with structured and unstructured clinical, operational, or RWD data, including multimodal modeling and time‑series or simulation methods. Proficiency in Python and SQL, modern ML, optimization, and LLM‑development libraries, and reproducible MLOps practices. Strong communication, stakeholder‑management, and technical‑leadership skills.

Preferred Qualifications

Experience in healthcare, pharmaceutical development, MedTech, clinical development, or clinical operations. Experience applying RWD methods to clinical-trial design, including target-trial emulation, propensity methods, survival analysis, or time-to-event analysis. Experience delivering analytical products or applications used by clinical or business teams.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

#LI-GR1 #LI-Hybrid #JRDDS #JNJDataScience #JRD

Required Skills: Preferred Skills: Advanced Analytics, Coaching, Critical Thinking, Data Analysis, Data Privacy Standards, Data Quality, Data Reporting, Data Savvy, Data Science, Data Visualization, Digital Fluency, Econometric Models, Organizing, Process Improvements, Strategic Thinking, Technical Credibility, Workflow Analysis

The anticipated base pay range for this position is : $117,000.00 - $201,250.00

• Vacation –120 hours per calendar year
• Sick time - 40 hours per calendar year
• for employees who reside in the State of Colorado –48 hours per calendar year
• for employees who reside in the State of Washington –56 hours per calendar year
• Holiday pay, including Floating Holidays –13 days per calendar year
• Work, Personal and Family Time - up to 40 hours per calendar year
• Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
• Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
• Caregiver Leave – 80 hours in a 52-week rolling period10 days
• Volunteer Leave – 32 hours per calendar year
• Military Spouse Time-Off – 80 hours per calendar year
• For additional general information on Company benefits, please go to: - https://www.careers.jnj.com/employee-benefits

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at https://www.jnj.com/.

Our Credo calls on us to respect the dignity of every individual and create an environment for all people to thrive. Throughout the recruitment process - from application through hiring - we are committed to providing reasonable accommodations/adjustments for qualified candidates with disabilities. If you need support at any stage of the recruitment process, please complete our candidate accommodation request form so we can assist you.

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