Principal Applied AI Engineer

Redesign Health; Buffalo (NY); Hybrid; USD 260,000 - 420,000; Full time

Job summary

Redesign Health is hiring a Principal Applied AI Engineer to turn high‑level business workflows into scalable, self‑learning systems that power the firm’s decisions. You’ll ship with founder‑level ownership and investor judgment, staying ahead of frontier AI research and leading a team of senior technologists and researchers.

You will join a global group that partners with founders, investors, and healthcare providers to unlock high‑impact opportunities and scale AI-native workflows across the

Qualifications

• 10+ years in a senior technical role at a venture-backed startup, frontier AI lab, or investment firm.
• Expert in Python and/or TypeScript; proficient with modern agent frameworks and production-grade systems.
• Built or modified the harness around an agent: custom tools, CLIs, observability, and self-learning loops.
• Reinvented workflows around AI; experience with coding agents like Claude Code is a plus.
• Executive presence and ability to work with nontechnical leaders across the firm.

Responsibilities

• Redefine healthcare investing as a technical discipline and ship AI systems for strategic decisions.
• Push the frontier of applied AI with durable, long-horizon agents and context engineering.
• Raise the technical bar across the company, sharing reusable patterns and teaching teams.
• Create global patient impact by supporting founders and partners with transformative health AI.

Skills

Python

TypeScript

Agent frameworks

Anthropic Agent SDK

Lang/Deep Agents

Tools

MCP servers

Anthropic Agent SDK

Job description

About The Company

Redesign Health is a global venture and applied technology firm focused on building next-generation healthcare companies. We manage venture capital and venture buyout strategies, each powered by an AI operating system and team of leading technologists, entrepreneurs, and investors.

About The Company

Redesign Health is a global venture and applied technology firm focused on building next-generation healthcare companies. We manage venture capital and venture buyout strategies, each powered by an AI operating system and team of leading technologists, entrepreneurs, and investors.

Our venture capital strategy backs exceptional founders at the earliest stage—often before an idea is fully formed—and provides first institutional capital and an unmatched degree of strategic leverage and domain expertise through exit. Our venture buyout strategy partners with proven management teams through control investments and delivers outsized value by rewiring core products and workflows with AI.

Since inception in 2018, Redesign and our portfolio companies have touched the lives of more than 15 million patients, raised over $1.5 billion from premier institutional, sovereign, and strategic investors, and built distinctive partnerships with marquee healthcare organizations and senior leaders around the world.

Redesign is based in New York and has offices in Bengaluru, Los Angeles, and Riyadh.

About The Team

Redesign's technology practice combines a frontier applied AI lab with deep healthtech investing expertise. Members of the practice have founded companies worth more than two billion dollars and built systems that serve hundreds of millions of patients, providers, and expert users, and run inside NASA, CIA, and 90% of the Fortune 500.

The practice is responsible for Redesign's technical investments, supports founders with architect-level guidance and more than a million dollars in AI and cloud credits, and builds the agentic operating system at the core of our business. Just as importantly, we help every team at Redesign use that system to become more technical, more creative, and more self-sufficient. We believe everyone is a builder, and that AI can let exceptional operators turn their expertise into software at the speed of thought.

We are a team of founders and researchers, musicians and astrophysicists, caregivers and friends. We prize analytical rigor, intellectual humility, and a drive to learn, build, and teach. We have been working on language models since before they were large, but we still reinvent ourselves every day as technology changes how we work and collaborate. We believe that AI will do more good for humanity in healthcare than anywhere else. We know the most impactful member of our team will be someone we have not yet met, and we cannot wait to learn from them.

About The Job

We're hiring an ambitious, self-initiated, product-minded Principal Applied AI Engineer to build the agentic workflows that power Redesign’s most important decisions: the founders we back, the concepts we pursue, the people we hire, the investors we work with, and the healthcare partners we support. You will turn messy, high-judgment business workflows into scalable, self-learning systems that compound the firm’s impact.

You will ship with the ownership of a founder and the judgment of an investor. You keep current with frontier AI research and retool your tradecraft every day. You will join a global team of former founders, architects, and research scientists in a high-leverage role. Your peers will be among the most senior technical and business leaders at the firm. Interested and qualified candidates may hire and manage additional engineers as needed.

What You'll Do

• Redefine healthcare investing as a technical discipline. You will design and ship AI systems to unlock one of the world's densest and highest-impact repositories of healthtech venture knowledge. You will embed with our investment, talent, and global development teams to solve problems in deep research, alternative people and organizational data, and human‑agent interaction. You will constantly raise the bar on the level of technical sophistication that we embody and offer to our founders, portfolio, and healthcare partners.
• Push the frontier of applied AI. You will build durable, long‑horizon agents, combine complex human judgment with context engineering and self‑improving feedback loops, and constantly invent things that didn't exist yesterday. As appropriate, you will publish, open‑source, and share what you learn across our portfolio, our healthcare partners, and the broader research community.
• Raise the technical bar across the company. You will use the work you ship to teach the organization what AI can do, contribute reusable patterns back to our core systems, and help teammates and portfolio companies understand how to build differently in an AI‑native world.
• Create global patient impact. As a technologist‑investor, you will source, assess, inspire, and close exceptional founders, then support them in building enduring, transformative health technology companies that serve millions of patients and providers around the world.

What You'll Need

We value and actively seek exceptional talent from all backgrounds and experiences, recognizing that excellence takes many forms. We care less about the specific arena than about clear evidence of superlative peer‑relative performance: being selected into high‑talent environments, distinguishing yourself within them, earning unusually broad scope or trusted ownership, progressing rapidly, or doing work that changed the trajectory of a team, product, company, or field. While every path is different, we believe the most successful candidates for this role will share the following characteristics:

• You have spent 10+ years in a senior technical role at a major venture‑backed startup, frontier AI lab, or investment firm. Bonus points for founding a company and building a product from 0‑1, or for meaningful time inside a VC or similar.
• You are an expert in Python and/or TypeScript and have written and reviewed millions of lines of code. You are proficient with modern agent frameworks (Lang* / Deep Agents, the Anthropic Agent SDK, or similar) and have shipped systems on top of them in production.
• You have built or materially modified the harness around an agent: custom tools or agentic CLIs, MCP servers, durable and sandboxed execution, observability, and self‑learning loops. You have built stateful, long‑horizon agentic systems well beyond basic RAG, and have wrestled with the evals, context engineering, and failure modes that emerge when models sit in front of real business users. Bonus points for a pre‑LLM background in machine learning, knowledge graphs, semantic search, or for having built CRM‑like intelligence products such as enterprise RevOps or recruiting software.
• You have completely reinvented your workflow around AI. You've built sophisticated systems on top of coding agents like Claude Code (skills, MCPs, custom harnesses for development and code review) and have hardly written code by hand in over a year.
• Technology is one of your passions, but you find deep meaning in some other pursuit to which you've devoted your time, thought, and effort: a creative or athletic outlet, a family business, or service.

Who You Are

• You are a relentless, startup‑native technologist with a high tolerance for ambiguity and an even higher speed of execution.
• You are obsessive about building products people love. Where others see requirements, you see people trying to do difficult work with imperfect tools. You earn their trust by working alongside them, and you go to unreasonable lengths to make sure what you build creates outsize impact.
• You architect interfaces for agents as deliberately as most engineers architect interfaces for humans. You think about tools, context, memory, evals, and failure recovery as product surfaces.
• You are drawn to the messy human systems where data, relationships, and expertise are combined to predict the future. Ideally you have worked inside an investment firm, built software for one, or spent enough time around investors and operators to understand how they work.
• You have an outstanding executive presence and can skillfully elicit critical information about what to build. You help nontechnical leaders understand "the art of the possible" and they trust you because you deliver for them.
• You have thrived in a group of passionate, talented, diverse, and low‑ego individuals because these kinds of people love working with you.
• You are deeply motivated to transform global healthcare and see technology as the true calling through which you can better the world.
• You have accomplished something most people haven't: started a company, won an international academic award, shipped a product loved by many, performed music around the world, or overcome difficult circumstances to succeed. You have dedicated your life to excellence in your craft.

How We Work

• Patients are waiting: Work with the urgency that patients deserve.
• AI sets the floor: Nothing short of what AI in expert hands can deliver; taste and judgment own the last mile.
• Stack the team: Talent density is our greatest asset; raise the bar with every hire.
• Trust people, challenge ideas: Assume good intent; never shy from rigorous debate.
• Sweat your craft: Take pride in your work; seek feedback to continuously improve.
• Go beyond: Your role, comfort zone, and expectations for what’s possible.
• Be the partner you want: High integrity, responsive, and genuinely invested in shared success.
• No shortcuts: Patient safety, clinical standards, and partner trust above all.

Compensation and Location

You will work on a hybrid schedule from our offices in New York, San Francisco, or Bengaluru. We target world‑class talent and compensate accordingly, with packages containing a mix of cash and fund equity.