Postdoctoral Scholar - Cell and Biological Systems

Penn State University; Hershey (PA); On-site; USD 52,000 - 70,000; Full time

Job summary

Penn State University in Hershey, PA invites applications for a Postdoctoral Scholar in the College of Medicine, Department of Cell and Biological Systems to investigate mitochondrial metabolism and metabolic stress signaling in cancer metastasis. The lab examines actin cytoskeleton remodeling, mtDNA homeostasis, and mitochondrial biogenesis; applicants should have a Ph.D.

or equivalent and a strong background in biochemistry or molecular biology.

Qualifications

• Ph.D. or equivalent required in a relevant field.
• Experience in biochemistry, molecular biology, or cancer metabolism preferred.

Responsibilities

• Study mitochondrial metabolism and metabolic stress signaling in cancer metastasis.
• Mentored training and opportunities for grant writing, manuscript preparation, and teaching.

Skills

Biochemistry

Molecular biology

Cancer metabolism

Education

Ph.D. or equivalent degree

Job description

## Postdoctoral Scholar - Cell and Biological SystemsApplylocations: College of Medicinetime type: Full timeposted on: Posted Todayjob requisition id: REQ\_0000080798# **APPLICATION INSTRUCTIONS:*** ## CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, apply internally through Workday.* ## CURRENT PENN STATE STUDENT (not employed previously at the university) and seeking employment with Penn State, please login to Workday to complete the student application process. Please do not apply here, apply internally through Workday.* ## If you are NOT a current employee or student, please click “Apply” and complete the application process for external applicants. **Approval of remote and hybrid work is not guaranteed regardless of work location. For additional information on remote work at Penn State, see Notice to Out of State Applicants.**This is a term position; length of the term will be discussed during the interview process. Continuation past the term length discussed will be based on university need, performance, and/or availability of funding. **POSITION SPECIFICS**The College of Medicine, Department of Cell and Biological Systems is seeking a postdoctoral scholar position in Dr. Shengyu Yang’s lab in Hershey, PA to study the role of mitochondrial metabolism and metabolic stress signaling in cancer metastasis. Our goal is to reveal how the mitochondrial metabolism and nutrient stress controls metastatic progression through epigenetic remodeling.This project is built on our recent discoveries that the actin cytoskeleton remodeling in metastatic cancer cells is able to control mitochondrial metabolism through regulating the homeostasis of mtDNA and the biogenesis of mitochondrial respiratory chain. Please see our publications for more information (Li et al, 2026, Nature Communications, PMID: 41476081; Wang et al, 2022, Cancer Res, PMID: 35413105; Lin et al, 2019, Cell Reports, PMID: 31509745; Lin et al, 2019, EMBO Mol Med, PMID: 31633874, ). Biochemistry, cell biology, genetically engineered mouse models and patient-derived organoids / xenografts will be employed in the study.Successful applicants will be a highly motivated individual with a Ph.D. or equivalent degree and will have expertise in biochemistry, molecular biology, cancer metabolism or related fields.Experience with genetically engineered mouse models and Next Generation Sequencing data analysis will be desirable but not required.Individuals will benefit from trainings in orthotopic lung cancer and/or pancreatic cancer metastasis models, metabolomics/lipidomics, metabolic flux analysis and genetically-engineered cancer mouse models. There are also training opportunities in improving grant and manuscript writing skills, teaching, mentoring and presentation.The research in Dr. Yang’s lab is funded by grants from the National Cancer Institute, National Institute on Aging and Department of Defense. Penn State College of Medicine Campus is located in Hershey, PA. Hershey is a quiet, family friendly town with affordable living expense and easy access to major metropolitan areas (e.g. Philadelphia, Washington DC, New York City). Please attached and send cover letter, CV and contact information for three references to Dr. Shengyu Yang at [e-mail] **BACKGROUND CHECKS/CLEARANCES**This position requires the following clearances in addition to applicable background checks: PA State Police Criminal Background Check, PA Child Abuse History Clearance Form, and Federal (FBI) Fingerprint Criminal Background Check. **BENEFITS**Penn State provides a competitive benefits package for full-time employees designed to support both personal and professional well-being. For more detailed information, please visit our Benefits Page. (Note: For Postdoctoral benefits, please see our Postdoctoral Benefits page.) **CAMPUS SECURITY CRIME STATISTICS**Pursuant to the Jeanne Clery Disclosure of Campus Security Policy and Campus Crime Statistics Act and the Pennsylvania Act of 1988, Penn State publishes a combined Annual Security and Annual Fire Safety Report (ASR). The ASR includes crime statistics and institutional policies concerning campus security, such as those concerning alcohol and drug use, crime prevention, the reporting of crimes, sexual assault, and other matters. The ASR is available for review here.**EEO IS THE LAW**Penn State is an equal opportunity employer and is committed to providing employment opportunities to all qualified applicants without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability or protected veteran status. If you are unable to use our online application process due to an impairment or disability, please contact 814-865-1473.