Postdoctoral Researcher in Agentic AI, Machine Learning, and Immunology

Los Alamos National Laboratory; Los Alamos (NM); On-site; USD 89,550 - 109,450; Full time

Benefits offered by this job

Medical insurance (PPO or HDHP)

Dental and vision insurance

Onsite gym and wellness programs

Tuition assistance

401(k) matching

Relocation package

Flexible schedules

Job summary

Los Alamos National Laboratory seeks a postdoctoral researcher to join the Theoretical Biology and Biophysics Group, focusing on computational biophysics at the immunology/biophysics interface. The role involves developing agentic AI workflows to interpret complex data and predict immune responses.

The candidate will build predictive ML models for protein interactions and antigen discovery, contributing to multi-disciplinary projects and collaboration with experimentalists.

Qualifications

• Minimum requirements include strong knowledge of immunology and experience with LLM APIs and agentic AI frameworks such as LangChain.
• Proficiency in Python, PyTorch, or TensorFlow and experience developing predictive and multimodal ML models.
• Ability to address uncertainty in limited, noisy, or high-dimensional biological data and to scale models in cloud or HPC environments.

Responsibilities

• Join research efforts at the interface of Immunology, Computer Science and Biophysics within LANL.
• Develop LLM-based agentic workflows to interpret complex biological data and predict immune responses to vaccines and therapeutics.
• Build ML models for protein-protein and protein-small-molecule interactions, antigen discovery, and immune-response modeling.

Skills

Immunology

LLM APIs

Python

PyTorch

TensorFlow

Predictive modeling

Uncertainty handling

Cloud/HPC

Antigen discovery

Protein interactions

Immune-response modeling

Education

PhD in related field

Job description

What You Will Do

We are looking for an independent and creative individual with an excellent record to join our research efforts in projects at the interface of Immunology, Computer Science and Biophysics. This postdoctoral position is available to work in the field of computational biophysics in the Theoretical Biology and Biophysics Group at the Los Alamos National Laboratory.

We are seeking a postdoctoral researcher with expertise in agentic AI, machine learning, and immunology. The successful candidate will develop LLM-based agentic workflows to interpret complex biological data and predict immune responses to vaccines and therapeutics.

The candidate should also have experience building machine-learning models for protein-protein and protein-small-molecule interactions, antigen discovery, and immune-response modeling.

What You Need

Minimum Job Requirements:

• Strong knowledge of immunology
• Experience with LLM APIs and agentic AI frameworks such as LangChain
• Proficiency in Python, PyTorch, or TensorFlow
• Experience developing predictive and multimodal ML models
• Ability to address uncertainty in limited, noisy, or high-dimensional biological data
• Experience scaling models in cloud or HPC environments
• Background in antigen discovery, protein interactions, or immune-response modeling

Desired Qualifications:

• Excellent written and oral communication skills
• Past research collaborations with experimentalists
• Experience in multi-disciplinary research projects.

Education: PhD in related field completed within the last 5 years or soon to be completed.

Work Location: The work location for this position is onsite and located in Los Alamos, NM.

Salary: Starting salary for a new graduate is currently $99,500.00 and increases with years of experience post PhD. For more information on salary and benefits, please visit LANL's Postdoctoral Research page: https://collaboration.lanl.gov/postdoctoral-research/

Note to Applicants: For further information please contact: [e-mail]. For information on projects, please check the following webpage: https://cnls.lanl.gov/External/people/Gnana.html

This job ad will remain open until December 31, 2026, or until positions are filled. Candidates may be considered for a Director's Fellowship and outstanding candidates may be considered for the prestigious Marie Curie, Richard P. Feynman, J. Robert Oppenheimer, or Frederick Reines Fellowships.

Where You Will Work: Located in beautiful northern New Mexico, Los Alamos National Laboratory (LANL) is a multidisciplinary research institution engaged in strategic science on behalf of national security. Our generous benefits package includes:

• PPO or High Deductible medical insurance with the same large nationwide network
• Dental and vision insurance
• Free basic life and disability insurance
• Paid childbirth and parental leave
• Award-winning 401(k) (6% matching plus 3.5% annually)
• Learning opportunities and tuition assistance
• Flexible schedules and time off (PTO and holidays)
• Onsite gyms and wellness programs
• Extensive relocation packages (outside a 50 mile radius)

Additional Details: Directive 206.2 - Employment with Triad requires a favorable decision by NNSA indicating employee is suitable under NNSA Supplemental Directive 206.2. Please note that this requirement applies only to citizens of the United States. Foreign nationals are subject to a similar requirement under DOE Order 142.3A.

No Clearance: Position does not require a security clearance. Selected candidates will be subject to drug testing and other pre-employment background checks.

New-Employment Drug Test: The Laboratory requires successful applicants to complete a new-employment drug test and maintains a substance abuse policy that includes random drug testing. Although New Mexico and other states have legalized the use of marijuana, use and possession of marijuana remain illegal under federal law. A positive drug test for marijuana will result in termination of employment, even if the use was pre-offer.

Internal Applicants: Regular appointment employees who have served the required period of continuous service in their current position are eligible to apply for posted jobs throughout the Laboratory. If an employee has not served the required period of continuous service, they may only apply for Laboratory jobs with the documented approval of their Division Leader. Please refer to Policy Policy P701 for applicant eligibility requirements.

Equal Opportunity: Los Alamos National Laboratory is an equal opportunity employer. All employment practices are based on qualification and merit, without regard to protected categories such as race, color, national origin, ancestry, religion, age, sex, gender identity, sexual orientation, marital status or spousal affiliation, physical or mental disability, medical conditions, pregnancy, status as a protected veteran, genetic information, or citizenship within the limits imposed by federal, state, and local laws and regulations. The Laboratory is also committed to making our workplace accessible to individuals with disabilities and will provide reasonable accommodations, upon request, for individuals to participate in the application and hiring process. To request such an accommodation, please send an email to [e-mail] or call (505)-664-6947.