Postdoctoral Research Fellow - Wachter Lab

Boston, United States; Boston (MA); Sur place; USD 72 000 - 76 000; Plein temps

Résumé du poste

The Wachter Lab at Dana-Farber Cancer Institute is seeking a postdoctoral fellow to advance biochemistry and structural biology projects addressing molecular mechanisms of transcriptional control. A PhD in structural biology or related field is required, with strong interest in molecular machines and significant scientific questions.

Onsite in Boston, with access to cryo-EM and crystallography facilities. Applicants should have proven ability to develop and execute complex projects, analyze

Qualifications

• Recent Ph.D. or equivalent in structural biology, biochemistry, biophysics or molecular biology.
• Proven ability to develop and execute on complex structural biology projects.
• Ability to collect and analyze experimental data, prepare publications and communicate results.
• Ability to work in a collaborative, team environment.
• Excellent oral and written capabilities.

Responsabilités

• Develop and execute complex structural biology projects.
• Apply cryo-EM and X-ray crystallography to study transcriptional mechanisms.
• Collect, analyze data and contribute to publications.
• Collaborate with a multidisciplinary team in a dynamic lab.

Connaissances

Structural biology

Biochemistry

Molecular biology

Oral and written communications

Formation

PhD in structural biology or related field

Outils

X-ray crystallography

Cryo-EM

NMR

Description du poste

Jobs in Structural Biology and Related Fields

The Wachter Lab seeks a highly motivated individual to join the team as a postdoctoral research fellow who will work on biochemistry and structural biology projects addressing fundamental questions in our understanding of molecular mechanisms of transcriptional control. While various backgrounds will be considered, a strong interest in understanding how molecular machines work and the desire to tackle a major problem of great significance are absolutely essential.

The Wachter Lab at Dana-Farber Cancer Institute is a Structural and Chemical Biology lab that combines molecular biology, structural biology, functional genomics and proteomics to study mechanisms of transcriptional regulation associated with human diseases, including cancer. The Wachter lab integrates structural biology, molecular biology and computational guided approaches to address fundamental questions about the mechanistic principles of transcription.

The laboratory is based at Dana-Farber Cancer Institute in Longwood Center and is an affiliate of the pediatrics department at Harvard Medical School. They are affiliated with state-of-the-art facilities for structural biology (cryo-EM, X-ray crystallography, NMR), chemistry, biophysics, cellular imaging, etc. The lab is a member of the DFCI Chemical Biology Program with access to in house cryo EM screening. Join their highly interactive team to work on mechanisms of transcriptional control and leverage these insights to test new avenues for therapeutic development.

• Recent Ph.D. or equivalent degree in structural biology (X-ray crystallography, electron microscopy), biochemistry, biophysics or molecular biology.
• Proven ability to develop and execute on complex structural biology projects.
• Ability to collect and analyze experimental data, prepare research publications and communicate results
• Ability to work in a collaborative and team environment
• Excellent oral and written capabilities
• Expertise in two or more of the following areas:
  • Expertise in recombinant protein expression and purification
  • Experience with insect and/or mammalian expression systems
  • Proficiency in data collection and structure determination for either X-ray or cryo-EM
  • Experience with protein biophysical techniques
  • In vitro biochemistry and enzyme kinetics
  • Quantitative and computational skills

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

Job Ref: JR-8760
Location: 450 Brookline Ave, BOSTON, MA 02215
Category: Fellowships
Employment Type: Full time
Work Location: Onsite, 100% onsite
Salary/Pay Rate: $72,000.00 - $76,385.00 per year