Postdoctoral Research Fellow (Mout) Immunobiology

Cincinnati Children's; Cincinnati (OH); On-site; USD 55,000 - 65,000; Full time

Job summary

Cincinnati Children’s is seeking a postdoctoral scientist in the Immunobiology division to advance protein design and immune function research. The lab integrates computational design, immunology, cell biology, and stem cell biology to study immune cell development and signaling.

The successful candidate will design experiments, analyze data, present findings, and contribute to grant writing while mentoring junior staff.

Qualifications

• PhD/MD or equivalent in biology, immunology, or a related field.

Responsibilities

• Develop the skills to become an independent scientist through critical thinking and data analysis.
• Design, execute, and record laboratory experiments with data analysis to inform decisions.
• Research and improve current methods; ensure protocol accuracy; troubleshoot equipment and results.
• Discuss insights with Faculty and provide recommendations based on data.
• Present research at meetings and develop skills to critically review and discuss data.
• Draft and edit scientific reports, papers, abstracts, and grants.
• Progressively assume greater responsibilities with mentorship and fiscal oversight.
• Maintain currency in the field through continuing education, seminars, and literature.

Skills

Critical thinking

Data analysis

Experimental design

Education

PhD/MD or equivalent (biology/immunology)

Job description

Primary Location

Location S

Department

Immunobiology

Shift

Day (United States of America)

Schedule

Full time

Weekly Hours

40

FTE

1

Employee Status

Regular

A postdoctoral position is available in Dr. Rubul Mout’s laboratory within the Division of Immunobiology, Division of Oncology, and the Center for Stem Cell and Organoid Medicine (CuSTOM) at Cincinnati Children’s Hospital Medical Center (CCHMC).

The Mout Lab develops innovative protein-based technologies to enhance immune function and advance next-generation cancer vaccines and immunotherapies. The lab integrates state-of-the-art computational protein design, immunology, cell biology, and stem cell biology to understand and control immune cell development and signaling.

Key Research Areas

• De novo protein design and humanization — Protein Design
• Enhancing T-cell function using designed proteins — Immunotherapy
• Rejuvenating T-cell development — Immuno-aging
• Developing rare dendritic cell populations — Cancer Vaccines

Dr. Mout received training in computational protein design in the laboratory of Nobel Laureate David Baker at the University of Washington and in stem cell biology and immunology in the laboratory of George Daley at Harvard Medical School.

His research has contributed to the design of complex protein assemblies and the development of a first-of-its-kind de novo soluble Notch agonist that facilitates cellular development, particularly immune cell development. His work has been published in Cell, Nature, Nature Communications, PNAS, and other leading scientific journals.

Major Duties And Responsibilities

• Develop the skills and knowledge (critical thinking and analysis of data, devising specific aims, long-term project planning and experimental design) to become an independent scientist
• Design, execute, and record laboratory experiments, and analyze data, which may affect decisions regarding future patient care.
• Research and improve current methods and evaluate innovative techniques. protocol and assay accuracy by conducting regular quality and reproducibility checks. Implement this knowledge in the Division/Department. Troubleshoot and correct erroneous results or problems with laboratory equipment.
• Discuss relevant insights about experimental results with Faculty and provide useful recommendations and analysis.
• Present research at laboratory meetings, journal clubs, seminars, and meetings. Develop skills to critically review and discuss data being presented.
• Draft, write, and edit scientific reports, papers, journal articles, abstracts, and grants.
• Progressively increasing responsibilities with mentorship of research staff and fiscal administration
• Maintain currency in field through continuing education, literature, and seminars. Be an active participant in the process through intellectual discussions with PI and other faculty, trainees and research staff. Solicit feedback on career trajectory from PI, mentoring committee and others who can provide coaching and insight.
• Attend required Cincinnati Children’s training sessions and ensure regulatory compliance with all institutional (i.e. Infection Control, ORCRA and others as applicable) policies and procedures
• Perform other duties as assigned.

Required

• PhD/MD or equivalent; biology, immunology, or a related field.

Preferred;

• Candidates with a strong interest in protein engineering, immunology, stem cell biology, or cancer immunotherapy are encouraged to apply.

About Us

At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a holistic team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s.

Cincinnati Children's Is

• Recognized by U.S. News & World Report as atop 10 best Children's Hospitals in the nation for more than 15 years
• Consistently among the top 3 Children's Hospitals for National Institutes of Health (NIH)Funding
• Recognized as one of America’s Best Large Employers (2025), America’s Best Employers for New Grads (2025)
• One of the nation'sAmerica’s Most Innovative Companiesas noted by Fortune
• Consistently certified as great place to work
• A Leading Disability Employeras noted by theNational Organization on Disability
• Magnet® designated for the fourth consecutive time by theAmerican Nurses Credentialing Center (ANCC)

Comprehensive Job Description Provided Upon Request.

Cincinnati Children’s is proud to be an Equal Opportunity Employer committed to creating an environment of dignity and respect for all our employees, patients, and families. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, genetic information, national origin, sexual orientation, gender identity, disability or protected veteran status. EEO/Veteran/Disability