Postdoctoral Position in Cancer Metabolism and Molecular Imaging

University of Pennsylvania Perelman School of Medicine; Meadville (Crawford County); On-site; USD 60,000 - 85,000; Full time

Benefits offered by this job

Visa sponsorship available

Job summary

The University of Pennsylvania is seeking a postdoctoral researcher to join the Penn Image-Guided Interventions Laboratory within the Departments of Radiology and Cancer Biology. The fellow will work on cancer metabolism and tumor microenvironment studies using hyperpolarized MRI, PET, and mass spectrometry–based metabolomics in a multidisciplinary setting.

Responsibilities include experimental design, data interpretation, manuscript preparation, and advancing projects toward first-author

Qualifications

• PhD or equivalent doctoral degree required by start date.
• Candidates from a broad range of fields encouraged to apply.
• Experience in cancer biology, biochemistry, chemistry, engineering or related disciplines is valued.

Responsibilities

• Design experiments and interpret results within cancer metabolism studies.
• Prepare manuscripts and help shape new research directions.
• Collaborate with co-principal investigators and multidisciplinary team.

Skills

Scientific initiative

Analytical skills

Written and verbal communication

Independent work

Multidisciplinary collaboration

Team collaboration

Education

PhD or equivalent doctoral degree

Tools

Hyperpolarized MRI

Mass spectrometry–based metabolomics

NMR spectroscopy

Mammalian cell culture

Animal experimentation

Chemistry

Job description

University of Pennsylvania: Postdoctoral Positions: Perelman School of Medicine Postdoctoral

Location

University of Pennsylvania - School of Medicine

Open Date

Oct 21, 2026

Description

Dr. David Tischfield, Assistant Professor of Radiology at the University of Pennsylvania, is seeking a postdoctoral researcher to join his research program within the Penn Image-Guided Interventions Laboratory, directed by Dr. Terence Gade. Based in the Departments of Radiology and Cancer Biology, the laboratory brings together investigators with complementary expertise in cancer biology, chemistry, engineering, imaging, and clinical medicine. The fellow will work closely with Dr. Tischfield and collaborate with other co-principal investigators and team members on integrated studies that draw on this multidisciplinary expertise.

Dr. Tischfield’s research program investigates cancer metabolism and the tumor microenvironment to develop molecular imaging approaches and therapeutic strategies. The position emphasizes preclinical hyperpolarized carbon-13 MRI, PET, and mass spectrometry–based metabolomics, integrating imaging with mechanistic studies in cells and animal models of cancer.

The postdoctoral researcher will initially contribute to completing ongoing studies and will then take increasing ownership of projects leading to first-author publications. Working closely with Dr. Tischfield and collaborators, the fellow will design experiments, interpret results, prepare manuscripts, and help shape new research directions.

Research Activities Include

• Preclinical hyperpolarized MRI and PET studies of tumor metabolism and treatment response
• Metabolomics and stable isotope tracing experiments
• Mechanistic studies using mouse models, mammalian cell culture, and molecular and biochemical assays
• Integration of imaging, mass spectrometry, and biological data
• Maintenance of rigorous experimental records
• Communication of findings through manuscripts and scientific presentations

A minimum two-year commitment is expected, with a preferred duration of four years to support project development and first-author publications. Please note that all appointments are for one year-periods, with reappointment on a yearly basis.

Qualifications

Applicants must hold a PhD or equivalent doctoral degree by the start date. Candidates from a broad range of fields are encouraged to apply, including:

• Cancer biology
• Biochemistry
• Chemistry
• Biomedical engineering
• Physics
• Related disciplines

We recognize that relevant experience varies across fields and will consider each applicant’s overall research background and potential.

Candidates Should Demonstrate

• Scientific initiative
• Strong analytical skills
• Strong written and verbal communication skills
• Ability to work independently
• Ability to work collaboratively in a multidisciplinary environment

Relevant experience in one or more of the following is preferred:

• Preclinical imaging
• Hyperpolarized MRI, conventional MRI, or NMR spectroscopy
• Mass spectrometry–based metabolomics or stable isotope tracing
• Chemistry
• Mouse handling and animal experimentation
• Mammalian cell culture
• Molecular biology or biochemical methods

Expertise in every area is not expected. However, willingness to work with animals and to develop complementary experimental skills is essential.

The University of Pennsylvania is committed to supporting a diverse and inclusive workforce and, in most cases, is able to sponsor visas for qualified applicants. Visa sponsorship for this position is contingent upon eligibility as determined by the specific funding source and applicable regulations.