Postdoctoral Fellow/Scientist I, Synthetic Spatial Omics (Imaging Technology)

Biohub; New York (NY); On-site; USD 93,000 - 150,000; Full time

Benefits offered by this job

401(k) match program

Paid time off to volunteer

Relocation support

Family-forming benefits

Job summary

Biohub in New York is seeking an exceptional Postdoctoral Fellow/Scientist I to drive development and application of next-generation spatiotemporal omics technologies that resolve immune cell state dynamics in situ. You will integrate imaging-based multi-omics with sequencing and systems-level analysis to study immune cells in their native microenvironment.

The role offers exposure to cutting-edge technology, collaboration across genomics, immunology, ML, and neuroscience, with opportunities to

Qualifications

• PhD required in a relevant life sciences field.
• 2-4 years post-PhD experience with single-cell omics or imaging-based approaches.
• Strong track record developing experimental technologies.
• Experience with cell culture, nucleic acid workflows, and functional assays.
• Ability to design rigorous experiments and drive projects to completion.
• Collaborative mindset and strong scientific communication skills.
• Background in immunology or immune engineering is preferred.

Responsibilities

• Develop imaging-based technologies to measure molecular organization and cell state dynamics.
• Profile immune cell states and disease states in spatial context.
• Analyze high-dimensional imaging and sequencing data to identify regulatory principles.
• Collaborate with researchers across genomics, synthetic biology, immunology, ML, and related fields.
• Contribute to preprints, publications, presentations, and open science practices.

Skills

Single-cell technologies

Imaging-based technologies

Molecular biology techniques

Cell culture

Experiment design

Scientific communication

Immunology background

Education

PhD in Genomics, Molecular Biology, Bioengineering, Systems Biology, or related

Tools

Imaging instrumentation

Sequencing platforms

Job description

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.

The Team

The Chan Zuckerberg Biohub New York is an independent nonprofit research institute that brings together three powerhouse universities - Columbia University, The Rockefeller University, and Yale University - into a single collaborative technology and discovery engine. Biohub itself supports some of the brightest, boldest engineers, data scientists, and biomedical researchers to investigate the fundamental mechanisms underlying disease and develop new technologies that will lead to actionable diagnostics and effective therapies. We are guided by our values of scholarly excellence; disruptive innovation; hands‑on engineering/hacking/building; partnership and collaboration; open communication and respect; inclusiveness; and opportunity for all.

Our Vision

• We pursue large scientific challenges that cannot be pursued in conventional environments
• We enable individual investigators to pursue their riskiest and most innovative ideas
• The technologies developed at Biohub facilitate research by scientists and clinicians at our home institutions and beyond

Diversity of thought, ideas, and perspectives are at the heart of Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.

The Opportunity

We are seeking an exceptional Postdoctoral Fellow/ Scientist I with a creative mindset to drive the development and application of next-generation spatiotemporal omics technologies that resolve immune cell state dynamics and organization. The successful candidate will develop and apply advanced imaging-based multi-omics technologies, integrate them with sequencing-based approaches and systems-level analysis, and use these platforms to measure cellular functions in situ, capture dynamic cell states, and identify molecular drivers of specific functional states. This position offers the opportunity to push the frontier of single-cell and spatiotemporal omics, while developing expertise at the intersection of technology development and fundamental discovery within a highly collaborative, interdisciplinary research environment.

The newly established Laboratory of Synthetic Spatial Omics at CZ Biohub NY advances our understanding of engineered immune cell function within their native microenvironment to design better cell therapeutic approaches. Toward this goal, we develop and integrate state-of-the-­art immune cell engineering, imaging-based and sequencing-based multi-omics, and machine learning/AI frameworks. We bring together scientists with diverse expertise to pursue highly interdisciplinary scientific challenges.

What You’ll Do

• Develop next-generation imaging-based technologies to measure molecular organization and cell state dynamics.
• Apply these technologies to profile immune cell states, disease states, and their spatial context.
• Analyze high-dimensional imaging and sequencing datasets using computational approaches to identify organizational and regulatory principles.
• Collaborate closely with researchers across genomics, synthetic biology, immunology, machine learning, and related disciplines.
• Contribute to preprints, publications, presentations, and open science practices.

What You’ll Bring

• PhD in Genomics, Molecular Biology, Bioengineering, Systems Biology, or a closely related discipline.
• 2-4 years of experience post PhD (Scientist I) in single-cell technologies, including imaging-based and/or sequencing-based omics.
• Strong track record of developing novel experimental technologies.
• Experience with molecular biology techniques, including cell culture, nucleic acid workflows, and cellular functional assays.
• Ability to independently design rigorous experiments, troubleshoot complex workflows, and drive projects to completion.
• Collaborative mindset and strong scientific communication skills.
• Experience developing novel imaging-based technologies.
• Research background in immunology or immune engineering.
• Experience with advanced microscopy, instrumentation, or imaging-based transcriptomics/genomics.
• Experience with synthetic biology, protein design, or engineered cell systems.

Compensation

The New York City, NY base pay range for a new hire in this role is Postdoctoral Fellow = $93,000.00 & Scientist I = $120,000 - $150,000. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.

This position may be eligible to participate in our discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with our total rewards philosophy and may vary by role.

Benefits For The Whole You

• Provides a generous employer match on employee 401(k) contributions to support planning for the future.
• Paid time off to volunteer at an organization of your choice.
• Funding for select family-forming benefits.
• Relocation support for employees who need assistance moving

If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.