Postdoctoral Fellow — Peptide Synthesis Process Development

AbbVie; North Chicago (IL); On-site; USD 75,000 - 143,000; Full time

Job summary

AbbVie Inc. in North Chicago, IL is seeking a highly motivated Postdoctoral Fellow to join the Active Pharmaceutical Ingredient (API) team in PDS&T.

You will perform independent research in peptide synthesis process development, mentored by senior process chemists, and contribute to publications and internal knowledge sharing. The role emphasizes designing experiments, data analysis, collaboration across disciplines, and advancing platform development for peptide drug substance manufacturing

Qualifications

• PhD in organic chemistry, peptide chemistry, or a closely related discipline, awarded recently or expected before the start date.
• Strong practical experience and theoretical background in organic synthetic techniques, chromatographic separations, and analytical chemistry (e.g., HPLC, LC-MS, and NMR).
• Hands-on experience with solution-phase or solid-phase peptide synthesis, protecting-group selection, and peptide isolation, purification, and analysis is strongly preferred.

Responsibilities

• Plan and perform solution-phase and solid-phase synthesis of peptides and protected peptide fragments, including coupling, deprotection, resin cleavage, fragment condensation, and isolation.
• Design, plan, and execute hypothesis-driven experiments, including DoE studies, to advance platform development and process understanding of peptide synthesis and isolation.
• Apply analytical methods such as HPLC, LC-MS, and NMR to advance peptide process development.
• Collaborate with engineering and analytical sciences partners to develop scalable peptide manufacture and isolation processes.
• Independently troubleshoot technical challenges and recommend follow-up experiments or alternative approaches.
• Communicate scientific plans, progress, results, and recommendations through presentations and updates.

Skills

Organic synthesis

Chromatography

Analytical chemistry

HPLC

LC-MS

NMR

Problem solving

Scientific communication

Education

PhD in organic chemistry/peptide chemistry or related discipline

Tools

HPLC

LC-MS

NMR

Job description

AbbVie Inc. in North Chicago, IL is seeking a highly motivated Postdoctoral Fellow to join the Active Pharmaceutical Ingredient (API) team in PDS&T.

You will perform independent research in peptide synthesis process development, mentored by senior process chemists, and contribute to publications and internal knowledge sharing. The role emphasizes designing experiments, data analysis, collaboration across disciplines, and advancing platform development for peptide drug substance manufacturing