Postdoctoral Fellow-MSH-30030-279

Mount Sinai Health System; New York (NY); On-site; USD 73,000 - 80,000; Full time

Job summary

Mount Sinai Health System invites applications for a Postdoctoral Fellow in the Microbiology Department. The role focuses on translational host-pathogen and vaccine response studies in preclinical animal models, with influenza and SARS-CoV-2 work in BSL2/3+ facilities.

You will perform immune profiling of mouse lungs and contribute to multi-OMICS analyses. The successful candidate will have a PhD and hands-on experience with animal handling and serological assays, and will collaborate with a

Qualifications

• PhD required.
• Experience handling mice in BSL2 environments.
• Experience with OMICS data generation and analysis.
• Experience with serological assays (ELISA) and single-cell techniques (flow cytometry, RNA seq).

Responsibilities

• Hamster intranasal vaccination.
• Adjuvant formulation and vaccine admixing.
• Virus titration from nasal turbinates and lungs.
• Set up preclinical infection models with influenza and coronaviruses.
• Serological assays (ELISA, microneutralization, ADCC/ADCP).
• Cellular immunity assays (ELISPOT, flow cytometry).
• Single-cell immune profiling and OMICS data acquisition/analysis.

Skills

Mice handling

OMICS data analysis

ELISA serology

Flow cytometry

RNA-seq

Single-cell RNA-seq

Education

PhD

Job description

Job Description

Title: Postdoctoral Fellow

Salary: $75,796 per year

Department: Microbiology

Physical work location: One Gustave L. Levy Place Box #1124, NY, NY 10029

Name PI or Supervisor: Michael Schotsaert; [e-mail]; 212-241-4847

Web link to Lab: https://labs.icahn.mssm.edu/schotsaertlab/

Web link to Dep’t: https://icahn.mssm.edu/about/departments/microbiology

Administrative Contact: Molly Deroy; [e-mail]; 212-241-7318

Qualifications

Educational and other Requirements for the position: PhD required

Experience Required

• Experience with handling mice in BSL2 environments.
• Sample preparation for OMICS data generation. E
• xperience with serological assays (ELISA) and single cell techniques (flow cytometry, RNA seq,? ).
• OMICs data analysis with standard analysis pipelines.

Responsibilities

Details of Research Project

The postdoc will be involved in translational research projects that study host-pathogen interactions and host-vaccine responses in preclinical animal models. The research projects include work with guinea pigs, hamsters, mice and human primary cell cultures in BSL2/3/3+ facilities with SARS-CoV-2 and influenza virus. The aim of these studies is to find correlates of protection and understand host immune responses to viral infection and vaccination in different models. Special focus will be on immune profiling of mouse lungs in mice with skewed host immune responses upon respiratory infections. This work will be done at bio safety levels 2 (influenza virus) and 3 (SARS-CoV-2) in the lab.

Technical Duties

• Hamster intranasal vaccination
• Adjuvant formulation and vaccine admixing
• Virus titration from nasal turbinates and lungs in preclinical animal models
• Setting up preclinical infection models with influenza virus and coronaviruses
• Serological assays (ELISA, microneutralization assays, ADCC assays, ADCP assays)
• Cellular mediated immunity assays (ELISPOT, flow cytometry)
• (Single cell) immune profiling (flow cytometry, single cell and bulk RNAseq, luminex cytokine ELISA, …) and assist with multi-OMICS data acquisition and analysis

About Us

Strength through Unity and Inclusion

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.

About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children’s Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

Equal Opportunity Employer

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.

Compensation Statement

Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.