Postdoctoral Fellow-MSH-12300-127

Mount Sinai Health System; New York (NY); On-site; USD 73,000 - 80,000; Full time

Job summary

The Mount Sinai School of Medicine invites applications for a Post-Doctoral Fellow in the laboratory of Dr. Joshua Brody, Director of the Lymphoma Immunotherapy Program, in New York.

The successful candidate will design and carry out a wide range of immunology experiments, including flow cytometry and ELISA, and will manage lab operations and inventory. Responsibilities include planning protocols, interpreting results, preparing figures, and supporting publications.

Qualifications

• Bachelors Degree in sciences or related field or equivalent experience.
• Ph.D. Degree in sciences or related field preferred.
• 3 years in a research environment.
• Microsoft Word, Excel, PowerPoint Intermediate
• Flow Cytometry Analysis Software Intermediate
• Excellent organizational, problem solving and analytical skills
• Excellent verbal, written and interpersonal communication skills
• Knowledge of standard research concepts
• Non-Bargaining Unit, 031 - Hematology & Medical Oncology - ISM, Icahn School of Medicine

Responsibilities

• Conducts a variety of research experiments using advanced research techniques.
• Coordinates project activities to meet deadlines.
• Collaborates with the Principal Investigator in the development of new experiments and research techniques.
• Assists in the implementation of standardized protocols for experiments and training purposes.
• Assists the Principal Investigator with publications by extracting and compiling data; reviewing and editing articles for publication.
• Mentors and trains less experienced research staff and graduate students.
• Ensures compliance with safety and regulatory requirements.
• Performs other related duties

Skills

MS Word

Excel

PowerPoint

Flow Cytometry Software

Organizational skills

Analytical skills

Written and verbal communication

Problem solving

Education

Bachelor's degree in sciences or related field

Ph.D. degree preferred

Tools

MS Word

Excel

PowerPoint

Job description

Job Description

The Mount Sinai School of Medicine has a Post-Doctoral Fellow opening immediately available in the laboratory of Dr. Joshua Brody – Director, Lymphoma Immunotherapy Program. This individual will perform a wide variety of moderately complex laboratory tasks/experiments, and maintain lab equipment and inventory levels of supplies.

Responsibilities of this position involve designing protocols and carrying out experiments, interpreting results, and preparing figures to convey analyses. Experimental duties will include but are not limited to performing cellular and molecular immunology techniques such as Flow Cytometry, ELISA, Luminex, and studies with animals as well as primary patient specimens.

The lab will provide the chance to learn novel aspects of basic and tumor immunology, multi-parametric flow cytometry and phospho-flow signaling studies, animal techniques including bone marrow transplantation, anti-tumor vaccinations, and a large variety of functional assessments of anti-tumor T cell induction.

Our lab has the rare opportunity to both perform correlative studies on primary patient tumor samples from early phase clinical trials and to continually develop advancements in those trials based on what is learned. The core mission is the translation of basic science in tumor immunology into novel and rapidly accruing clinical trials as exemplified in recent high-impact publications:

Svensson-Arvelund J, Cuadrado-Castano S, Pantsulaia G, Kim K, Aleynick M, Hammerich L, Upadhyay R, Yellin M, Marsh H, Oreper D, Jhunjhunwala S, Moussion C, Merad M, Brown BD, García-Sastre A, Brody JD Expanding cross-presenting dendritic cells enhances oncolytic virotherapy and is critical for long-term anti-tumor immunity. Nat Commun . 2022 Nov 22;13(1):7149.

Anagnostou T, Brody JD. In CAR T cell-treated lymphomas, the T cell rich get richer. Nat Med . 2022 Sep;28(9):1757-58.

Lin MJ, Svensson-Arvelund J, Lubitz GS, Marabelle A, Melero I, Brown BD, Brody JD. Cancer vaccines: the next immunotherapy frontier. Nat Cancer . 2022 Aug;3(8):911-926.

Lubitz GS, Brody JD. Not just neighbours: positive feedback between tumour-associated macrophages and exhausted T cells. Nat Rev Immunol . 2022 Jan;22(1):3.

Upadhyay R, Boiarsky JA, Pantsulaia G, Svensson-Arvelund J, Lin MJ, Wroblewska A, Bhalla S, Scholler N, Bot A, Rossi JM, Sadek N, Parekh S, Lagana A, Baccarini A, Merad M, Brown BD, Brody JD. A Critical Role for Fas-Mediated Off-Target Tumor Killing in T-cell Immunotherapy. Cancer Discov . 2021 Mar;11(3):599-613. doi: 10.1158/2159-8290.CD-20-0756.

Marshall N, Hutchinson K, Marron TU, Aleynick M, Hammerich L, Upadhyay R, Svensson-Arvelund J, Brown BD, Merad M, Brody JD. Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade. Cancer Discov. 2019 Nov;9(11):1520-1537.

Hammerich L, Marron TU, Upadhyay R, Svensson-Arvelund J, Dhainaut M, Hussein S, Zhan Y, Ostrowski D, Yellin M, Marsh H, Salazar AM, Rahman AH, Brown BD, Merad M, Brody JD. Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination. Nat Med. 2019 May;25(5):814-824.

Qualifications

Job Qualifications:

Bachelors Degree in sciences or related field or equivalent experience. Ph.D. Degree in sciences or related field preferred.

Minimum Related Experience:

3 years in a research environment

Minimum Computer Skills:

(provide program and skill level, e.g. MS Word - Basic) (skill levels are Basic, Intermediate, Advanced)

Microsoft Word, Excel, Powerpoint Intermediate

Flow Cytometry Analysis Software Intermediate

General Skills:

Excellent organizational, problem solving and analytical skills

Excellent verbal, written and interpersonal communication skills

Knowledge of standard research concepts

Non-Bargaining Unit, 031 - Hematology & Medical Oncology - ISM, Icahn School of Medicine

Responsibilities

1. *Conducts a variety of research experiments using advanced research techniques.
2. *Coordinates project activities to meet deadlines.
3. *Collaborates with the Principal Investigator in the development of new experiments and research techniques.
4. *Assists in the implementation of standardized protocols for experiments and training purposes.
5. *Assists the Principal Investigator with publications by extracting and compiling data; reviewing and editing articles for publication.
6. Mentors and trains less experienced research staff and graduate students.
7. Ensures compliance with safety and regulatory requirements.
8. Performs other related duties

About Us

Strength through Unity and Inclusion

The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual.

At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history.

About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint‑venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s "Best Children’s Hospitals" ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s "The World’s Best Smart Hospitals" ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

Equal Opportunity Employer

The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.

Compensation Statement

Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.