Postdoctoral Fellow, Infection Immunodiagnostics & Immunopathogenesis

University of Cincinnati; Cincinnati (OH); Sur place; USD 52 000 - 72 000; Plein temps

Avantages offerts par ce poste

Tuition remission

Retirement plans

Work-life balance

Health coverage

Professional development

Résumé du poste

The University of Cincinnati College of Medicine invites applications for a full-time Postdoctoral Fellow in the Immunopathogenesis/Immunotoxicology laboratory. The position focuses on immunology research related to mycobacterial lung disease, with emphasis on immunodiagnostics and immune signatures.

The research will explore immune determinants, immunopeptidome, and host biomarkers to advance differential diagnostics.

Qualifications

• PhD or equivalent in immunology, infection microbiology, or related life sciences.
• Experience with immunology, microbiology and molecular biology techniques relevant to infectious/immune lung disease studies.
• Salary commensurate with relevant experience.

Responsabilités

• Design and perform experiments on pathogen antigens and host immune responses in in‑vitro/ex‑vivo models of mycobacterial lung disease.
• Conduct epitope discovery using high‑throughput serologic, cellular, and proteomic approaches.
• Validate candidate immunogens in mouse models and patient biospecimens.
• Perform immune profiling on patient and control samples using flow cytometry and omics methods.
• Maintain accurate research records and contribute to data analysis, manuscripts, and grant reports.
• Collaborate with colleagues across immunology, microbiology, and assay development.

Connaissances

Immunology techniques

Microbiology techniques

Molecular biology techniques

Formation

PhD or equivalent in immunology or related life sciences

Outils

Immunoassays

Flow cytometry

Immunopeptidomics

T-cell activation

Molecular cloning/recombinant expression

Description du poste

Current UC employees must apply internally via SuccessFactors

Next Lives at the University of Cincinnati

Founded in 1819, the University of Cincinnati ranks among the nation’s best urban public research universities. Home to more than 53,600 students, 12,000 faculty and staff, and over 360,000 living alumni, UC, a Carnegie 1 institution, combines research prowess with a physical setting The New York Times has called “the most ambitious campus design program in the country.” UC's momentum has never been stronger as the anchor of the Cincinnati Innovation District, the oldest cooperative education (co‑op) program in the country with students earning $94 million annually through paid experiences, an academic health system, and as a member of the Big 12 Conference. The university contributes $10.6 billion in economic impact to the city and $22.7 billion to the state of Ohio. At UC, next is all of us. Learn more at uc.edu.

UC is a mission‑driven organization where we are committed to student success and positively transforming the community through scholarship and service. We thrive on innovation, making an impact, and fostering an environment where staff and faculty are key contributors to UC’s success.

Job Overview

As one of the oldest medical schools in the country, the University of Cincinnati College of Medicine (COM) has a reputation for training best‑in‑class health care professionals and developing cutting‑edge procedures and research that improve the health and clinical care of patients. In partnership with the UC Health academic healthcare system and Cincinnati Children’s Hospital Medical Center, College of Medicine’s faculty are transforming the world of medicine every day. The Department of Environmental and Public Health Sciences is a top‑tier department with world‑renowned faculty and staff.

A full‑time Postdoctoral Fellow position is available in the Immunopathogenesis/ Immunotoxicology laboratory of Dr. Jagjit Yadav at the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. The position is focused on immunology research on a mycobacterial lung disease, with emphasis on immunodiagnostics and immunopathogenesis.

The research will involve identifying immune determinants (epitopes)/immunopeptidome and immunogen‑specific host biomarkers associated with disease pathogenesis, with the long‑term goal of developing differential diagnostics and understanding antigen presentation and other immune mechanisms of the disease. The work will involve use of seroreactive protein arrays, immunopeptidomics (MHC peptide identification), recombinant expression, immunoassays, and lymphocyte immunophenotyping to identify disease‑specific cellular and molecular immune signatures, followed by development of multiplex assays and lymphocyte biomarkers of the disease.

Essential Functions

• Design, perform, troubleshoot, and analyze experiments related to pathogen antigens/epitopes and host immune responses in in‑vitro/ex‑vivo cellular and in‑vivo models of mycobacterial lung disease.
• Conduct B‑and T‑cell epitope discovery experiments using high‑throughput serologic, cellular, and proteomic approaches involving high‑density peptide arrays, immunopeptidomic platform, and multiplex immunoassays.
• Perform recombinant/synthetic generation and downstream characterization of candidate immunogens. Perform validation studies using mouse models and patient biospecimens.
• Carry out immune profiling studies on patient and control biospecimens (blood, sputum, BALF), including lymphocyte subset analysis and identification of antigen‑specific molecular signatures/biomarkers using flow cytometry and single‑cell OMICs approaches.
• Maintain accurate research records and contribute to data analysis, manuscript preparation, grant‑related reports, and scientific presentations.
• Collaborate with investigators across immunology, microbiology, immunoproteomics, and assay development research expertise.
• Keep informed of developments in the field of microbial lung disease immunodiagnostics /immunopathogenesis to maintain and enhance professional expertise.
• Engage in appropriate training and professional development opportunities.
• Play an active role in seeking career and research advice from the faculty supervisor and other faculty members.
• Lab maintenance, including equipment maintenance and ordering of supplies, as needed.

Minimum Requirements

• Prior to effective date of appointment, a PhD or equivalent degree in immunology, infection microbiology, or a related branch of life sciences.

Additional Qualifications Considered

• Prior experience in immunological, microbiological, and molecular biology techniques relevant in infectious/immune lung disease studies or basic vaccinology research, such as immunoassays, flow cytometry, antigen/epitope discovery, immunopeptidomics, T‑cell activation, and/or molecular cloning/recombinant expression.
• Salary will be commensurate with relevant experience.

Physical Requirements/Work Environment

• Office environment/no specific unusual physical or environmental demands.

Compensation And Benefits

UC offers an exceptional benefits package designed to support your well‑being, financial security, and work‑life balance. (UC Benefits) Eligibility may vary by position and FTE status. Highlights include:

Comprehensive Tuition Remission

UC provides tuition remission for you and your eligible dependents, covering tuition costs for nearly all undergraduate and graduate programs offered by the university.

Robust Retirement Plans

As a UC employee, you won’t contribute to Social Security (except Medicare). Instead, you’ll choose between state pension plans (OPERS, STRS) or an Alternative Retirement Plan (ARP), with UC contributing 14–18% of your salary based on position.

Real Work‑Life Balance

UC prioritizes work‑life balance with a generous time‑off policy, including:

• Vacation and sick time
• 11 paid holidays and additional end‑of‑year paid time off (Winter Season Days)
• 6 weeks of paid parental leave for new parents

Additional Benefits Include

• Competitive salary based on experience
• Comprehensive health coverage (medical, dental, vision, prescription)
• Flexible spending accounts & wellness programs
• Professional development & mentorship opportunities

To learn more about why UC is a great place to work, please visit our Careers Page.

UC is an E‑Verify employer. If hired into this position, you will be required to provide satisfactory proof of employment eligibility by providing acceptable, original forms of identification for employment verification via the Federal I‑9 employment verification process. Click here for a list of acceptable documents.

Important

To apply you must create a profile and submit a complete job application through the UC applicant portal. We are unable to consider “easy apply” applications submitted via other websites. For questions about the UC recruiting process or to request accommodations with the application, please contact UC HR at [e-mail].

Equal Opportunity Employer. Building a workplace where all qualified applicants will receive consideration for employment, including Individuals with Disabilities and Protected Veterans.