Postdoctoral Associate | Sickle Cell Disease | Agoro Lab

The Jackson Laboratory; Bar Harbor (ME); On-site; USD 65,589 - 75,569; Full time

Job summary

The Agoro lab at The Jackson Laboratory for Mammalian Genetics in Bar Harbor, ME seeks a postdoctoral fellow to identify mechanisms triggering sickle cell crisis. The project combines systems biology, genetics, genomics, proteomics and metabolomics to map disease progression and heterogeneity.

You will develop new mouse models, work with patient data, and apply cutting-edge tools including CRISPR‑based editing and single-cell multi-omics, collaborating with JAX researchers and external

Qualifications

• Ph.D. in cell biology, molecular biology, genetics, or related field of study.
• Strong training background in molecular biology, cell biology, next‑generation sequencing technology.
• Experience in computational biology, genetic screens and single‑cell technologies are particularly preferred.
• Candidates should have at least one 1st author publication record in peer‑reviewed journal.
• Excellent writing and communication skills, able to work independently and effectively with other members in a productive team.

Responsibilities

• Develop new mouse models that recapitulate disease phenotypes and heterogeneity.
• Work with data generated from sickle cell disease patients and perform integrative analyses.
• Apply cutting‑edge technologies including CRISPR‑based tools and single‑cell multi‑omics.

Skills

Molecular biology

Cell biology

Next-generation sequencing

Computational biology

Single-cell technologies

Genetic screens

Education

Ph.D. in cell biology, molecular biology, genetics, or related field

Job description

Postdoctoral Associate | Sickle Cell Disease

Agoro Lab

Bar Harbor, ME

The Agoro lab at the Jackson Laboratory for Mammalian Genetics is seeking a highly motivated postdoctoral fellow to identify mechanisms that trigger sickle cell disease crisis. The goal of our laboratory is to determine the mechanisms of disease severity heterogeneity using systems biology. We use a multidisciplinary approach that integrates genetics, genomics, proteomics, and metabolomics to isolate systemic and tissue-specific marker of disease progression.

The ideal candidate would have a strong background in molecular biology, and genomic technologies. Exceptional candidates can show early independence through the JAX Scholars Program. The selected candidate will have the opportunity to collaborate with other laboratories within the JAX community and with external collaborators who are translational scientists and clinicians.

As a postdoctoral scientist in our lab, you will pioneer the development of new mouse models that recapitulate disease phenotypic heterogeneity as seen in patients. You will work with data generated from sickle cell disease patients. In our group, you will apply a broad range of cutting‑edge technologies, including CRISPR-based tools, single‑cell multi‑omics, and create new disease mouse models that better recapitulate disease phenotype.

The Jackson Laboratory (http://www.jax.org) in Bar Harbor, Maine, USA, is recognized internationally for its research excellence, unparalleled mouse resources, state of the art facilities for computational science, mass spectrometry, imaging science, genome technologies, outstanding training environment characterized by scientific collaborations, and exceptional core services - all within a spectacular setting adjacent to Acadia National Park. In addition to lab-based training, JAX has developed a unique program for trainees to expand their professional skills in science communication, entrepreneurship, teaching, mentoring and laboratory management to best prepare postdocs for future career opportunities.

QUALIFICATIONS

• Ph.D. in cell biology, molecular biology, genetics, or related field of study.
• Strong training background in molecular biology, cell biology, next‑generation sequencing technology.
• Experience in computational biology, genetic screens and single‑cell technologies are particularly preferred.
• Candidates should have at least one 1st author publication record in peer‑reviewed journal.
• Excellent writing and communication skills, able to work independently and effectively with other members in a productive team.

Please submit your current CV, 3 letters of reference, and 1‑page (maximum) statement of Research Interests and Career Goals at time of application.

We are an inclusive research group, aspiring to produce top science and scientists through attentive and progressive mentoring and interdisciplinary teamwork.

JAX Salary
Year 0 - 1 $65,589
Year 1 - 2 $67,318
Year 2 - 3 $69,095
Year 3 - 4 $70,521
Year 4 - 5 $72,877
Year 5 - 6 $75,569

Based on years of experience as Postdoc

About JAX:

The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute‑designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California), Japan and China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.

Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visit www.jax.org.

EEO Statement:

The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.