Postdoctoral Associate - Metabolomics, Lipidomics and Cancer

Baylor College of Medicine; Houston (TX); Sur place; USD 52 000 - 66 000; Plein temps

Résumé du poste

Baylor College of Medicine in Houston, TX, is seeking a Postdoctoral Associate in Metabolomics, Lipidomics and Cancer to join the Pediatrics division. The role focuses on nutrition, metabolism, and metabolic diseases, employing untargeted and targeted metabolomics, isotope tracing, and in vivo/in vitro models using a Thermo Exploris 480 LC/MS system.

The successful candidate will define mechanisms of methionine restriction–mediated tumor inhibition, explore therapeutic potential across cancer

Qualifications

• MD or Ph.D. in Basic Science, Health Science, or a related field.
• No experience required.

Responsabilités

• Plans, directs and conducts specialized and advanced research experiments.
• Evaluates and analyzes data.
• Establishes new research protocols and procedures.
• Summarizes research findings and publish results in research journals.
• Works on and responsible for laboratory operations.
• Supervises research staff.

Connaissances

Analytical chemistry

Cell biology

Biochemistry

Molecular biology

Metabolism

Cancer

Diabetes

Formation

MD or Ph.D. in Basic Science, Health Science, or a related field

Outils

Thermo Exploris 480 LC/MS

Description du poste

Postdoctoral Associate - Metabolomics, Lipidomics and Cancer

• Job Title: Postdoctoral Associate - Metabolomics, Lipidomics and Cancer
• Division: Pediatrics
• Work Arrangement: Onsite only
• Location: Houston, TX
• Salary Range: Per NIH Guidelines
• FLSA Status: Exempt
• Work Schedule: Monday – Friday, 8 a.m. – 5 p.m.

Summary

A postdoctoral associate position is available in Dr. Xia Gao's laboratory in the Department of Pediatrics at Baylor College of Medicine. The lab is interested in the interactions of nutrition, metabolism, and the development and treatment of metabolic diseases such as obesity and cancer. The goal is to identify nutritional interventions and metabolic pathways for prevention and treatment of metabolic diseases. The lab employs untargeted and targeted metabolomic analysis and isotope tracing studies using newly vested in-house Thermo Exploris 480 LC/MS instrument. Along with this powerful analytical tool, we use various in vivo mouse models and in vitro models to define the role of nutritional input and the underlying mechanisms in disease development and control. For instance, the lab has recently (Nature, 2019) employed metabolomics approaches to show that dietary methionine restriction is an effective and feasible dietary intervention in healthy humans and mice to alter circulating metabolism without overt side effect. Dietary methionine restriction has shown promising in various mouse cancer models alone or in combination with chemotherapy or radiotherapy.

• Define the mechanisms underlying methionine restriction mediated tumor inhibition
• Determine the therapeutic potential of dietary methionine restriction in various cancer types and stages
• Investigate amino acid metabolism in adipogenesis

Job Duties

• Plans, directs and conducts specialized and advanced research experiments.
• Evaluates and analyzes data.
• Establishes new research protocols and procedures.
• Summarizes research findings and publish results in research journals.
• Works on and responsible for laboratory operations.
• Supervises research staff.

Minimum Qualifications

• MD or Ph.D. in Basic Science, Health Science, or a related field.
• No experience required.

Preferred Qualifications

• Experience or expertise in analytical chemistry, cell biology, biochemistry, molecular biology, mouse physiology, metabolism, cancer, diabetes.

Work Authorization Requirement:

This position is not eligible for visa sponsorship. Candidates must be legally authorized to work in the United States at the time of application and throughout the duration of employment.

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

Baylor College of Medicine fosters diversity among its students, trainees, faculty, and staff as a prerequisite to accomplishing our institutional mission and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient-centered care.

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.