Postdoctoral Associate - GaMBiT Initiative

Broad Institute; Cambridge (MA); On-site; USD 65,000 - 95,000; Full time

Benefits offered by this job

Visa sponsorship

Benefits package

Job summary

The Broad Institute invites exceptional postdoctoral associates to join the Klarman Fellowship within the GaMBiT Initiative, focusing on translating genetic discoveries into precise disease mechanisms and therapeutic leads. Both computational and experimental track options are available, with mentors from Broad, MIT, or Harvard-affiliated labs.

Roles emphasize large-scale genomic analyses, tool development for researchers, and AI-driven integration of genetic data with literature.

Qualifications

• Strong analytical and written communication skills.
• Ability to work effectively in an interdisciplinary environment.
• Commitment to GaMBiT Initiative activities.

Responsibilities

• Building large-scale analyses across siloed biobanks to create genome maps of disease.
• Develop tools for experimentalists to access comprehensive genome information per disease.
• Build AI agents for integrating and interpreting genetic data with biological knowledge from literature.

Skills

Analytical skills

Written communication

Interdisciplinary collaboration

Education

Ph.D. in Computational Biology or related

Job description

The position:

The Klarman Fellowship, a postdoctoral research program within the GaMBiT Initiative at the Broad Institute of MIT and Harvard is seeking exceptional postdoctoral associates to join this bold endeavor.

The mission of the Broad Institute is to understand the roots of disease and close the gap between new biological insights and impact for patients. The GaMBiT Initiative aims to bridge the translation gap between genetic discoveries and therapeutic interventions by systematizing and scaling essential experiments that will articulate disease mechanisms from genetic discoveries, identify critical biomarkers which measure those mechanisms, build the computational framework to link human genetics data with these experiments, and ultimately deliver therapeutic approaches which precisely remediate the discovered mechanisms.

We welcome outstanding applicants with research interests in any area of research germane to the development and application of novel technologies to advance the GaMBiT mission to convert the discovery of hundreds to thousands of genetic variants connected to any disease into precise causal mechanisms, biomarkers required to measure those mechanisms, and genuinely actionable therapeutic leads. Both computational and experimental postdoctoral fellows are required for this mission, mirroring the diverse network of labs involved in GaMBiT supported research which span diverse areas of expertise such as statistical and computational genetics, the articulation of disease mechanism using cellular and organismal biology, immunology, scalable biomarker discovery using metabolomics and proteomics, protein structure and chemistry.

Roles will be focused on:

Building large-scale analyses across siloed biobanks, integrating data across all studies to create genome maps of disease, developing tools for experimentalists to access comprehensive genome information per disease, and building AI agents for integrating and interpreting genetic data with biological knowledge from literature.

• Building large-scale analyses across siloed biobanks, integration of data across all studies to create genome maps of disease, tools for experimentalists to access comprehensive genome information per disease, AI agents for integrating and interpreting genetic data with biological knowledgebase available in literature.


• Scalable editing of any human cell type; profiling of proteins, regulatory elements, metabolites, and molecular interactions within single cells; human genetics-derived cellular models and organoids derived from patient tissues to which disease-specific perturbations can be applied).

Postdoctoral associates will be based at the Broad Institute with a mentor or co-mentors from Broad-, MIT-, or Harvard-affiliated faculty.

Completed application review will begin on a rolling basis after September 30, 2026.

This will be a one-year appointment beginning on or after January 1, 2027, or an earlier/later mutually agreed upon date, with the possibility of renewal for a second year based upon satisfactory performance.

Qualifications and Requirements:

• Within one year of Ph.D. (expected or obtained) in Computational Biology, Computer Science, Physics, Math, Statistics, Biochemistry, Immunology, Chemical or Molecular Biology, or a strong knowledge of a variety of biological areas of research.


• Strong analytical and written communication skills, including the ability to effectively describe scientific material to both specialized and lay audiences.


• Ability to work effectively in an interdisciplinary environment and commitment to participating in GaMBiT Initiative activities

Questions: please contact ([e-mail])

The Broad Institute will offer visa sponsorship for this opportunity.

The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law.

At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits.

The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations.

Should you need a reasonable accommodation to complete the application or interview process, please contact [e-mail] for assistance.