Postdoctoral Associate - Developmental Programming of Metabolic Disease

University of Florida (UF); Gainesville (FL); Presencial; USD 55 000 - 75 000; Tempo integral

Vantagens oferecidas por esta oferta de emprego

Health insurance

Life insurance

Retirement plan

Paid time off

Professional development

Tuition assistance

Public Service Loan Forgiveness

Resumo da oferta

The Karst laboratory at the University of Florida College of Medicine seeks a highly motivated postdoctoral associate to join a newly funded NIH R01 project examining how the early-life environment programs long-term metabolic health.

The successful candidate will explore mechanisms of bile acid signaling during lactation, focusing on adipose tissue development, progenitor trajectories, and lifespan metabolic outcomes, using mouse models, flow cytometry, lineage tracing, and single-cell

Qualificações

• PhD, MD/PhD, or equivalent doctoral degree in a relevant biomedical discipline.
• Strong background in biomedical sciences and demonstrated experience with hypothesis-driven research.
• Experience with molecular, cellular, or in vivo experimental approaches relevant to the project.

Responsabilidades

• Investigate cellular and molecular mechanisms of developmental programming by bile acid signaling.
• Examine how postnatal bile acid signaling shapes adipose tissue architecture and progenitor trajectories.
• Employ mouse models, flow cytometry, cell sorting, lineage tracing, metabolic phenotyping, and single-cell omics.

Conhecimentos

Mouse models

Flow cytometry

Lineage tracing

Metabolic phenotyping

Single-cell sequencing

Epigenomics

In vivo experiments

Formação académica

PhD or MD/PhD

Ferramentas

Flow cytometry

DNA/RNA sequencing

Lineage tracing techniques

In vivo mouse work

Descrição da oferta de emprego

The Karst laboratory in the Department of Molecular Genetics and Microbiology at the University of Florida College of Medicine is seeking a highly motivated postdoctoral associate to join a newly funded NIH R01 project investigating how the early-life environment programs long-term metabolic health.

Our laboratory recently discovered that maternal bile acids delivered during lactation act as developmental signals that regulate neonatal growth through the bile acid receptor TGR5. Remarkably, transient manipulation of this pathway during lactation has lasting consequences: offspring exposed to reduced maternal milk bile acids are protected from diet-induced obesity, insulin resistance, hyperinsulinemia, and fatty liver in adulthood.

The successful candidate will investigate the cellular and molecular mechanisms underlying this developmental programming. Current studies focus on how bile acid signaling during early postnatal life establishes adipose tissue architecture and function, including effects on adipocyte progenitor populations and their developmental trajectories. Approaches will include mouse models, flow cytometry and cell sorting, lineage tracing, metabolic phenotyping, and single-cell genomic and epigenomic approaches.

This is a new and rapidly developing research direction in the laboratory, providing substantial opportunity for the successful candidate to contribute intellectually to the project, develop independent questions, and shape its future direction.

We are looking for a scientist who is curious, rigorous, collaborative, and interested in understanding how transient exposures during critical developmental windows can produce lifelong changes in physiology and disease susceptibility.

To view more information regarding research in the Karst lab, please visit www.thekarstlab.com.

PhD, MD/PhD, or equivalent doctoral degree in a relevant biomedical discipline.

Candidates should have a strong background in biomedical or biological sciences and demonstrated experience conducting rigorous, hypothesis-driven research. Preferred applicants will have experience with molecular, cellular, or in vivo experimental approaches relevant to the project.

A Criminal Background check is required, and this is not a remote work position. It is located on the University of Florida main campus in Gainesville, FL.

We Offer Exceptional Benefits:

• Low-cost State Health Plans: Medical, Dental, and Vision Insurance
• Life and Disability Insurance
• Generous Retirement Options to secure your future
• Comprehensive Paid Time Off Packages: (includes over 10 paid holidays, as well as paid family, sick and vacation leave)
• Exceptional Personal and Professional Development Opportunities: Access to UF Training & Organizational Development programs, leadership development, LinkedIn Learning, and more
• Tuition Assistance through the UF Employee Education Program
• Public Service Loan Forgiveness (PSLF) Eligible Employer

The University of Florida is an Equal Employment Opportunity Employer.

To learn more about Gainesville and the surrounding areas, please visit the Guide to Greater Gainesville, which shares information about our neighborhoods, schools, zoning, culture, leisure, and more at https://guidetogreatergainesville.com/.

Gainesville is a vibrant city with a low cost of living, diverse population, excellent public schools, Division I NCAA sports, and no state income tax. The area is known for its nature parks, bike trails, sporting events, museums, mild winters, and warm summers. Being centrally located, Gainesville is easily situated for a day trip to beautiful beaches along the Atlantic Ocean and the Gulf of Mexico, as well as to theme parks like Disney World. Other nearby cities include Orlando, Jacksonville, and Tampa. Learn more about what Gainesville has to offer at https://www.visitgainesville.com/.

To learn more about the University of Florida (UF), please visit https://www.ufl.edu/.