Postdoctoral Associate | Bennett Lab

Maine Tech Hub; Bar Harbor (ME); On-site; USD 66,000 - 76,000; Full time

Job summary

The Jackson Laboratory in Bar Harbor, Maine, seeks a talented researcher to lead an independent project on hematopoietic stem cell emergence, Maturation, and signaling pathways. You will work with TGFb/BMP signaling, single-cell genomics, and clonal barcoding in a highly collaborative setting across programs and external collaborators.

Responsibilities include designing and executing experiments, analyzing data, preparing manuscripts and grants, and mentoring junior members to advance academic

Qualifications

• Ph.D., M.D., or equivalent degree in biological sciences or related discipline.
• Minimum of one first-author publication from graduate studies or prior postdoctoral work.
• Strong foundational training in molecular biology, cell biology, developmental biology, or stem cell biology.
• Excellent verbal and written communication skills.
• Self-motivated and able to work independently as well as collaboratively.

Responsibilities

• Plan, develop, execute, and analyze an independent research project within the lab's focus areas.
• Mentoring junior lab members and contributing to a collaborative team environment; prepare manuscripts and fellowship applications.

Skills

Molecular biology

Cell biology

Developmental biology

Stem cell biology

Verbal communication

Written communication

Independent work

Education

Ph.D., M.D., or equivalent

First-author publication

Job description

at The Jackson Laboratory in Bar Harbor, Maine, United States

Job Description

The Bennett Lab is dedicated to uncovering the fundamental mechanisms that govern the developmental emergence of hematopoietic stem cells (HSCs) and translating these insights toward improved stem cell engineering for regenerative medicine.

The laboratory focuses on understanding HSC specification and maturation in embryonic development by:

1) defining how TGF-/BMP signaling regulate the transition from pre-HSCs to transplantable HSCs, including the role of SMAD7 and related downstream effectors.

2) the identification of novel regulators to this process and defining how rare pre-hematopoietic stem cell intermediates arise from hemogenic endothelium and mature into fully functional, multi-lineage engraftable HSCs.
Our long-term goal is to identify the precise molecular signals that enable robust HSC formation and use this knowledge to improve the efficiency of producing of transplantable HSCs for therapeutic purposes.

The Bennett lab uses a multidisciplinary approach integrating mouse genetics, embryo models, transplantation assays, flow cytometry, confocal microscopy, clonal barcoding, and single-cell genomics. The lab offers a highly collaborative environment with opportunities to work across programs at The Jackson Laboratory as well as with external collaborators in the field. Trainees will be supported in fellowship applications, publications, conference presentations, and career development toward academic or industry paths.

Responsibilities

The successful candidate will be able to plan, develop, execute, and analyze an independent research project within the lab's main focus areas. Potential projects may include mechanistic studies into how TGFb/BMP signaling pathways regulates pre-HSC maturation or mapping transcriptional states of developmental HSC emergence using single-cell and clonal barcoding approaches.
Additional responsibilities include preparing manuscripts, fellowship applications, and conference presentations, as well as mentoring junior lab members and contributing to a collaborative team environment.

Required Qualifications

• Ph.D., M.D., or equivalent degree in biological sciences or related discipline
• Minimum of one first-author publication from graduate studies or prior postdoctoral work
• Strong foundational training in molecular biology, cell biology, developmental biology, or stem cell biology
• Excellent verbal and written communication skills
• Self-motivated and able to work independently as well as collaboratively

Preferred Qualifications

Experience or training in any of the following areas:

• Hematopoiesis, stem cell biology, developmental biology, or vascular biology
• Mouse models, transplantation assays, or in vivo lineage tracing
• Flow cytometry, cell sorting, and primary cell culture
• Single-cell RNA-seq, ATAC-seq, spatial genomics, or related genomic technologies
• Lentiviral systems or clonal barcoding
• Computational biology, bioinformatics, or quantitative data analysis

JAX Salary

Year 0 - 1: $65,589

Year 1 - 2: $67,318

Year 2 - 3: $69,095

Year 3 - 4: $70,521

Year 4 - 5: $72,877

Year 5 - 6: $75,569

Based on years of experience as Postdoc

About JAX

The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California),Japan andChina. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.

Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visitwww.jax.org.

EEO Statement

The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status and other classifications protected by applicable state and local non-discrimination laws.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.