POSTDOCTORAL ASSOCIATE - Arnab Chatterjee Lab - Chemistry

Scripps Research; San Diego (CA); On-site; USD 70,000 - 75,000; Full time

Benefits offered by this job

Employer contributed retirement plan

Health and welfare plans

On-site parking

Paid vacation and sick leave

Job summary

Calibr-Skaggs Institute for Innovative Medicines, a division of Scripps Research, seeks a Postdoctoral Associate in medicinal chemistry to advance early-stage translational research. You will synthesize and characterize small molecules, optimize potency and pharmacokinetics, and contribute to the publication of high-impact results.

The role involves work under a Scripps Research faculty member, with up to five-year appointments and competitive NIH/Calif. salary guidelines.

Qualifications

• Ph.D. in chemistry or equivalent from a recognized institution.
• Strong skills and proven track record in synthetic organic chemistry and purification.
• Ability to design and improve synthetic routes to support SAR studies.
• Excellent documentation and collaborative communication skills.

Responsibilities

• Conduct SAR studies to optimize lead compounds.
• Design analogs based on modeling, literature, and medicinal chemistry principles.
• Synthesize and analyze target molecules using organic synthesis techniques.
• Generate drug-like candidates for progression to clinical studies.

Skills

Synthetic organic chemistry

Compound purification

Structural characterization

Literature search

SAR design

Communication skills

Team collaboration

Education

Ph.D. in chemistry

Tools

HPLC

NMR

MS

UV-Vis spectroscopy

Job description

About Us
Calibr-Skaggs Institute for Innovative Medicines, a division of Scripps Research, is a first-of-its-kind, nonprofit translational research institute dedicated to creating the next generation of medicines. Calibr-Skaggs was founded on the principle that the creation of new medicines can be accelerated by pairing world-class biomedical research with state-of-the-art drug discovery and development capabilities. Scripps Research is ranked one of the most influential institutions in the world for its impact on innovation. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists. Leveraging the unique scientific environment of Scripps Research, impacting translational sciences, Calibr-Skaggs has created a portfolio of drug candidates, and is shaping a new paradigm for advancing nonprofit biomedical research to impact patients while re-investing in further innovative research. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve wellbeing. Calibr-Skaggs’ drug development portfolio spans a broad range of human diseases, including cancer, autoimmunity and inflammatory diseases, metabolic and cardiovascular diseases, infectious and neglected diseases, as well as age-related and degenerative diseases. If you have a passion for making a difference, this could be your opportunity to join our transformative team. This position is based on site at our La Jolla campus.

About Us
Calibr-Skaggs Institute for Innovative Medicines, a division of Scripps Research, is a first-of-its-kind, nonprofit translational research institute dedicated to creating the next generation of medicines. Calibr-Skaggs was founded on the principle that the creation of new medicines can be accelerated by pairing world-class biomedical research with state-of-the-art drug discovery and development capabilities. Scripps Research is ranked one of the most influential institutions in the world for its impact on innovation. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists. Leveraging the unique scientific environment of Scripps Research, impacting translational sciences, Calibr-Skaggs has created a portfolio of drug candidates, and is shaping a new paradigm for advancing nonprofit biomedical research to impact patients while re-investing in further innovative research. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve wellbeing. Calibr-Skaggs’ drug development portfolio spans a broad range of human diseases, including cancer, autoimmunity and inflammatory diseases, metabolic and cardiovascular diseases, infectious and neglected diseases, as well as age-related and degenerative diseases. If you have a passion for making a difference, this could be your opportunity to join our transformative team. This position is based on site at our La Jolla campus.
POSITION TITLE: Postdoctoral Associate
Position SummaryCalibr-Skaggs Institute for Innovative Medicines is seeking talented Medicinal and Synthetic Postdoctoral Fellow candidates to join a dynamic, interdisciplinary team of scientists focused on early stage translational research. Postdoctoral researchers in the medicinal chemistry group will work as part of a team of scientists to synthesize and characterize small molecules that represent new therapeutic approaches to unmet medical needs. The researcher will be synthesizing and designing analogs designed to optimize the potency, pharmacokinetics, safety and in vivo efficacy of potential drug candidates. Work will be published in high-impact, peer-reviewed journals.
Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a Scripps Research Faculty member. These appointments are normally not renewed beyond a total of five years. Postdoctoral Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Postdoctoral Associates do not have consulting privileges.
Make Calibr-Skaggs Institute your next step to advance and develop your career. Click here to learn more about our Postdoctoral Program and Services: https://education.scripps.edu/postdoctoral/

Responsibilities

• Conduct structure-activity relationship (SAR) study to perform the optimization
• Design the analogs of the lead compounds based on the computer-aided molecular modeling, literature research and medicinal chemistry principles
• Synthesis and analysis the target molecules using varieties of techniques such as organic synthesis, column chromatography, HPLC analysis, nuclear magnetic resonance (NMR), MS/IR/UV spectroscopy, etc.
• Generate candidates with drug-like properties for progression to clinical studies

Requirements

• Ph.D. in chemistry, or equivalent degree from a recognized institution of higher learning. A pending doctoral degree may be considered with approval of the Principal Investigator and Human Resources.
• Strong skills and a proven track record in synthetic organic chemistry, compound purification, and structural characterization
• Profound literature search skills, the ability to design and improve synthetic routes to support SAR studies and deliver compound in large scale in timely manner
• Highly motivated, creative, and able to maintain excellent documentation of their work
• Able to collaborate proficiently and communicate effectively with colleagues and management team
• Excellent verbal, written, interpersonal and collaborative communication skills

Physical RequirementsThis position works in a laboratory environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process. COMPENSATION: Postdoctoral Associates will be hired following the National Institute of Health and California’s exempt salary guidelines, which provide for a starting range of $70,304- $75,353. Consideration will be given to experience that exceeds the listed requirements. Comprehensive Benefits Include

• Employer Contributed Retirement Plan – Depending on eligibility, employees receive an employer contributed retirement plan (no employee contribution required) and the option to contribute to a 403(b) (which is similar to a 401(k) using your own pre or post-tax dollars)
• Full Suite of Health and Welfare plans including three medical plan options (including an HSA available option), dental, vision, life insurance, disability, EAP and more
• Access to Flexible Spending Accounts (Medical/Dependent Care)
• Competitive vacation and sick leave policies
• Free, on-site parking

The above statements describe the level of work performed and expected in general terms. The statements are not intended to list all the responsibilities, duties and/or skills required of employees so classified, and the content herein is subject to change due to the business needs of Scripps Research, with or without notice. Furthermore, nothing in this job description shall be interpreted to be in conflict with or to eliminate or modify in any way the employment-at-will status of Scripps Research staff. EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. We promote diversity of thought, culture and background in the fields of science. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.