Postdoc: Single-Cell & Spatial Bioinformatics Lead

University of Pennsylvania; Philadelphia (Philadelphia County); On-site; USD 65,000 - 90,000; Full time

Job summary

University of Pennsylvania—Penn Dental Medicine invites applications for a Postdoctoral Fellow in Single-Cell and Spatial Bioinformatics and Quantitative Image Analysis. The position focuses on inflammatory processes across tissues, leading scRNA-seq and Xenium analyses, and supervising quantitative image-analysis studies of adhesion molecules in vivo. The fellow will collaborate with experimentalists, own analyses, and prepare first‑author manuscripts, with mentorship from Dr.

Dana T. Graves.

Qualifications

• PhD or equivalent in a relevant field.
• Hands-on bioinformatic analysis of scRNA-seq or spatial transcriptomics.
• Proficiency in R and modern single-cell workflows.
• Ability to work independently and collaborate across disciplines.
• Clear scientific writing and communication skills.
• Fields include bioinformatics, computational biology, genomics, biostatistics, or related.

Responsibilities

• Lead bioinformatic studies using scRNA-seq and Xenium spatial transcriptomic datasets.
• Lead quantitative image analysis of in vivo specimens to study adhesion molecules.
• Develop clear, reproducible computational workflows.
• Perform quality control, data integration, cell annotation, and differential expression analysis.
• Conduct pathway, trajectory, state-transition, and ligand–receptor analyses.
• Integrate multiomic, cross-species, and cross-cohort datasets.
• Integrate transcriptomic data with imaging, histology, and phenotypic measurements.
• Create figures and communicate results to collaborators.
• Help define analytical strategy and interpret biological findings.
• Present results and prepare first‑author manuscripts.
• Contribute to grant development and collaborative studies.

Skills

Doctoral degree

Bioinformatics - scRNA-seq

R programming

Independent work

Scientific writing

Interdisciplinary background

Scientific interpretation

Education

PhD/MD/DMD/DVM or equivalent

Tools

R

Seurat

Job description

University of Pennsylvania—Penn Dental Medicine invites applications for a Postdoctoral Fellow in Single-Cell and Spatial Bioinformatics and Quantitative Image Analysis. The position focuses on inflammatory processes across tissues, leading scRNA-seq and Xenium analyses, and supervising quantitative image-analysis studies of adhesion molecules in vivo. The fellow will collaborate with experimentalists, own analyses, and prepare first‑author manuscripts, with mentorship from Dr.

Dana T. Graves.