Postdoc Lead: Single-Molecule GPCR Signaling

ALSAC; Memphis (TN); On-site; USD 55,000 - 65,000; Full time

Job summary

St. Jude Children’s Research Hospital is seeking a Postdoctoral Research Associate to study GPCR signaling fidelity at the single-molecule level. The lab focuses on molecular biology, biochemistry of membrane proteins, and quantitative biophysical/computational approaches to advance GPCR-targeted drug discovery.

The ideal candidate will propose hypotheses, design experiments, and analyze data with minimal supervision, while mentoring others and contributing to publications and presentations.

Qualifications

• Ph.D. or equivalent in life sciences or physical sciences.
• 0–3 years of post-PhD experience is acceptable.
• Experience in GPCR signaling studies or single-molecule fluorescence analyses preferred.
• Direct experience with isolation and functional characterization of GPCRs and signaling partners is strongly preferred.

Responsibilities

• Lead experimental design, execution, and data analysis of biophysical GPCR studies.
• Engineer and isolate high-quality GPCRs and signaling partners for assays.
• Expand skills with smFRET imaging and quantitative modeling of GPCR signaling.
• Work independently, steering projects from hypothesis to presentations/publications.
• Collaborate within interdisciplinary, multi-institutional teams and present findings.

Skills

Molecular biology

Biochemistry

GPCR signaling

Single-molecule techniques

Education

PhD in life science or physical science

Tools

smFRET imaging

Single-molecule fluorescence

GPCR isolation

Job description

St. Jude Children’s Research Hospital is seeking a Postdoctoral Research Associate to study GPCR signaling fidelity at the single-molecule level. The lab focuses on molecular biology, biochemistry of membrane proteins, and quantitative biophysical/computational approaches to advance GPCR-targeted drug discovery.

The ideal candidate will propose hypotheses, design experiments, and analyze data with minimal supervision, while mentoring others and contributing to publications and presentations.