Research Postdoctoral Fellow - Chou Lab - Hematology with iPSC and red cell focus

Children's Hospital of Philadelphia; Philadelphia (Philadelphia County); On-site; USD 21,000 - 110,000; Full time

Job summary

Children’s Hospital of Philadelphia (CHOP) seeks a Postdoctoral Fellow to conduct independent scholarly research under a mentor, contributing to pediatric hematology research and the lab’s ongoing projects. The role provides training across data collection, analysis and manuscript development within a vibrant, collaborative environment in Philadelphia.

The position requires a terminal degree (PhD, MD, DVM, etc.) and experience with molecular biology, tissue culture, and lab management.

Qualifications

• PhD or equivalent required.

Responsibilities

• Conduct independent scholarly research and develop new methods and protocols.
• Participate in project planning, recording and evaluation of data.
• Acquire technical, lab management and grant writing skills.
• Participate in seminars, lectures, poster sessions and presentation at national meetings.
• Supervise junior lab members.
• Assist with other research projects.

Skills

Ability to wear a respirator device

Education

Doctorate

Job description

Seeking Breakthrough Makers

Children’s Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.

SHIFT:

Day (United States of America)

Seeking Breakthrough Makers

Children’s Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.

At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care—and your career.

CHOP does not discriminate on the basis of race, color, sex, national origin, religion, or any other legally protected categories in any employment, training, or vendor decisions or programs. CHOP recognizes the critical importance of a workforce rich in varied backgrounds and experiences and engages in ongoing efforts to achieve that through equally varied and non-discriminatory means.

A Brief Overview

Under the direction/guidance of a mentor (principal investigator), assumes responsibility for a specific, on-going research project. The experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities.

It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group.

This role will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. This position will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. This role also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

About The Laboratory

The postdoctoral fellow (postdoc) will have a terminal degree PhD, MD, DVM, etc. and will, under the direction/guidance of a mentor (principal investigator), assume responsibility for a specific, on-going research project. The position is in the laboratory of Dr. Stella Chou, a Principal Investigator in the Hematology Research Division. Her research focuses on pediatric blood diseases, mechanisms of normal and pathologic hematopoietic development, and the study of vitro generation of red blood cells from induced pluripotent stem cells (iPSCs) for transfusion medicine.

The postdoc experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group. Postdocs will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

Research foci include:

• Study and enhance in vitro generation of red blood cells from induced pluripotent stem cells (iPSCs) for transfusion medicine
• Use customized pluripotent stem cells with rare blood cell phenotypes to optimize their use as red cell reagents that would improve antibody identification in transfused patients with sickle cell disease.
• Identifying novel methods to expand pluripotent stem cell derived hematopoietic progenitors or improve red cell maturation that would facilitate use of iPSC-derived red cells for therapeutic purposes.
• Adaption of next generation sequencing technology to improve red cell matching and prevent alloimmunization in patients with sickle cell disease.
• Use CRISPR/Cas9 technology in pluripotent stem cells to manipulate specific genes that may enhance red blood cell proliferation, maturation, and enucleation.

The Chou laboratory is looking for candidates with a general molecular biology background and tissue culture experience. A background in hematopoiesis and/or experience with CRISPR technology or human primary, ESC, or iPSC culture would be a plus

What You Will Do

• Conduct independent scholarly research and develop new methods and protocols
• Participate in project planning, recording and evaluation of data
• Acquire technical, lab management and grant writing skills
• Participate in seminars, lectures, poster sessions and presentation at national meetings
• Supervise junior lab members
• Assist with other research projects

Education Qualifications

• Doctorate Required

Skills And Abilities

• Ability to wear a respirator device

To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must receive an annual influenza vaccine.

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SALARY RANGE:

$20,800.00 - $110,400.00 Annually

Salary ranges are shown for full-time jobs. If you're working part-time, your pay will be adjusted accordingly.

If you are applying for a Research Post-Doctoral Fellow role, please refer to this link for salary guidelines (copy & paste into your browser): https://www.research.chop.edu/services/hiring-a-postdoctoral-fellow#collapse-accordion-3523-3

At CHOP, we are committed to fair and transparent pay practices. Factors such as skills and experience could result in an offer above the salary range noted in this job posting. Click here for more information regarding CHOP's Compensation and Benefits.