Postdoc: Cancer Resistance & Biomarker Discovery

aa067; Duarte (CA); On-site; USD 60,000 - 75,000; Full time

Job summary

City of Hope in Duarte, CA invites applications for a Postdoctoral Fellow to join the Andrea H. Bild, PhD, lab focusing on intrinsic and acquired resistance in solid tumors. You will work at the intersection of molecular biology, genomics, and translational oncology to identify biomarkers and targets for therapy.

The role emphasizes designing experiments, integrating multi-omics data, and advancing biomarker-guided treatment strategies within translational research and clinical collaborations.

Qualifications

• Strong background in cancer biology and molecular signaling.
• Experience with cell culture and molecular biology techniques.
• Experience with CRISPR or genetic perturbation approaches.
• Experience with genomics, transcriptomics, or single-cell technologies.
• Experience with pharmacology and drug response studies.
• Excellent written and verbal communication skills.
• Demonstrated publication record in peer-reviewed journals.

Responsibilities

• Lead independent studies investigating molecular, cellular, epigenetic, and signaling mechanisms of resistance in solid tumors.
• Design and perform molecular, cellular, and pharmacologic experiments using cell-based, ex vivo, and patient-derived cancer models.
• Characterize oncogenic pathways, adaptive cellular states, and resistance-associated vulnerabilities.
• Integrate molecular, genomic, transcriptomic, epigenetic, and phenotypic data to identify drivers of response and resistance.
• Develop and validate predictive biomarkers of therapeutic outcomes, including blood-based assays and methylation tests.
• Advance translational studies supporting precision oncology trials and biomarker-guided strategies.
• Collaborate with basic, computational, and clinical investigators and present findings.
• Prepare manuscripts for publication in high-impact journals and contribute to grants.

Education

PhD or equivalent doctoral degree

Tools

CRISPR

Single-cell sequencing

Genomics

Bioinformatics tools

Job description

City of Hope in Duarte, CA invites applications for a Postdoctoral Fellow to join the Andrea H. Bild, PhD, lab focusing on intrinsic and acquired resistance in solid tumors. You will work at the intersection of molecular biology, genomics, and translational oncology to identify biomarkers and targets for therapy.

The role emphasizes designing experiments, integrating multi-omics data, and advancing biomarker-guided treatment strategies within translational research and clinical collaborations.