Post Doctoral Scholar - Pathology

The Ohio State University; Columbus (OH); Sur place; USD 52 000 - 68 000; Plein temps

Résumé du poste

The Ohio State University invites applications for a Post Doctoral Scholar in the Pathology/Medicine/Gene Regulation area to study RNA-mediated immune dysregulation in SLE, lupus nephritis, and RA. The role blends immunology, genomics, and computational biology to uncover pathways driving tissue injury and kidney inflammation.

You will work with T cells and dendritic cells, perform transcriptomic analyses, and disseminate results through publications and presentations.

Qualifications

• Ph.D., M.D., or M.D./Ph.D. in Immunology, Molecular Biology, Genetics, Computational Biology, Bioinformatics, or a related field.
• Strong background in immunology, including T cell and dendritic cell biology.
• Experience with transcriptomic data analysis (bulk or single-cell RNA-seq).
• Demonstrated research productivity with peer-reviewed publications in immunology or RNA biology.

Responsabilités

• Investigate the roles of T cells and dendritic cells in SLE, lupus nephritis, and RA.
• Define disease-associated immune cell states and molecular pathways using multi-omics.
• Integrate computational and experimental approaches to uncover mechanisms and targets.
• Identify RNA regulatory networks controlling immune activation and pathogenic function.
• Perform multi-parameter flow cytometry, cytokine assays, and co-culture systems.
• Execute murine autoimmune disease models and assess disease outcomes.
• Publish findings and contribute to grant applications.

Connaissances

Immunology

T cell biology

Dendritic cell biology

RNA regulatory mechanisms

Computational analysis

Flow cytometry analysis

Formation

Ph.D., M.D., or M.D./Ph.D. in Immunology or related field

Outils

FlowJo

RNA-seq analysis tools

Description du poste

Job Title:Post Doctoral Scholar - PathologyDepartment:Medicine | Pathology

Position Summary

We are seeking a highly motivated Post Doctoral Scholar to investigate the immunopathogenesis of systemic lupus erythematosus (SLE), lupus nephritis, and rheumatoid arthritis (RA) through the integrated study of immune cell function and RNA regulatory mechanisms. The successful candidate will combine advanced immunological approaches with genomic and computational analyses to identify RNA-mediated pathways that drive immune dysregulation, kidney inflammation, and tissue injury in autoimmune disease.

Responsibilities

• Investigate the roles of T cells and dendritic cells in SLE, lupus nephritis, and RA
• Define disease-associated immune cell states and molecular pathways using transcriptomic, epigenomic, and spatial omics approaches
• Integrate computational and experimental approaches to uncover biologically actionable mechanisms and therapeutic targets
• Identify RNA regulatory networks and RNA-binding protein-mediated mechanisms that control immune cell activation, differentiation, and pathogenic function
• Perform multi-parameter flow cytometry, intracellular cytokine staining, ELISAs, and T cell-dendritic cell co-culture assays
• Execute murine autoimmune disease models
• Assess disease outcomes including proteinuria, renal pathology, joint inflammation, autoantibody production, and immune cell phenotypes
• Publish findings in high-impact journals, present at scientific meetings, mentor trainees, and contribute to grant applications

Job Requirements

• Ph.D., M.D., or M.D./Ph.D. in Immunology, Molecular Biology, Genetics, Computational Biology, Bioinformatics, or a related field
• Strong background in immunology, including T cell biology and dendritic cell biology
• Experience with transcriptomic data analysis, including bulk RNA-seq and/or single-cell RNA-seq
• Demonstrated research productivity with peer-reviewed publications in immunology, RNA biology, genomics, or autoimmune disease
• Experience with multi-color flow cytometry, immune phenotyping, and FlowJo analysis
• Proficiency in immunological assays

Additional Information:Location:Tzagournis Medical Research Facility (0163)Position Type:Term (Fixed Term)Scheduled Hours:40

Shift

First Shift

Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post offer process.

The university is an equal opportunity employer, including veterans and disability.