Post Doctoral Scholar - Heart and Vascular Institute

Penn State University; Hershey (PA); On-site; USD 55,000 - 65,000; Full time

Job summary

The Penn State College of Medicine, Department of Heart and Vascular Institute, in Hershey, PA is seeking a Postdoctoral Scholar. This position in Dr.

Shyam Bansal’s laboratory will study the role of inflammatory immune responses in mediating cardiovascular diseases. Our laboratory uses multidisciplinary approaches to study the role of different immune subsets in regulating left-ventricular remodeling and cardiac dysfunction during heart failure.

Qualifications

• Doctoral degree with expertise in molecular biology and inflammation testing.
• Experience with in-vivo and in-vitro models and flow cytometry.

Responsibilities

• Perform small animal cardiac structure and functional analysis and conduct coronary ligation surgeries including echocardiography.
• Maintain cell lines and perform pharmacological assays, Western blotting and qRT-PCR.
• Oversee animal lines, transgenic mice and data analysis; train technicians.
• Present results in manuscripts, grants and formal presentations.

Skills

Animal handling

Western blotting

PCR

Flow cytometry

Cell culture

Data analysis

Communication

Independent work

Education

Doctoral degree in molecular biology

Tools

Gel electrophoresis

Flow cytometer

PCR instruments

Job description

Approval of remote and hybrid work is not guaranteed regardless of work location. For additional information on remote work at Penn State, see Notice to Out of State Applicants.

This is a term position; length of the term will be discussed during the interview process. Continuation past the term length discussed will be based on university need, performance, and/or availability of funding.

Position specifics

The Penn State College of Medicine, Department of Heart and Vascular Institute, in Hershey, PA is seeking a Postdoctoral Scholar. This position in Dr. Shyam Bansal’s laboratory will study the role of inflammatory immune responses in mediating cardiovascular diseases. Our laboratory uses multidisciplinary approaches to study the role of different immune subsets in regulating left-ventricular remodeling and cardiac dysfunction during heart failure. Our research spans from human to animal studies, employing novel imaging and electrophysiologic techniques such as flow cytometry, vesicular analysis, and echocardiography.

Duties include (but are not limited to):

• Perform small animal cardiac structure and functional analysis and conduct coronary ligation surgeries. This includes independently performing small animal echocardiography, real-time measurements of function using 2D, M-mode, & Doppler technology, as well as data analysis. Tissue harvesting, staining and flow analysis for immune cell subsets. Perform data analysis, and finally, write manuscripts/grants originating from this data. Isolate and perform analysis of exosomes
• Maintain cell line, perform pharmacological assays of cell lines with the microplate reader, perform Western blotting assays and quantitative RT-PCR assays.
• Independently monitor and carry out oversight of animal lines including transgenic mice colony maintenance, employing gel electrophoresis and PCR techniques. Analyze and plot data obtained from the assays performed.
• Provide training of other technicians to ensure that duties above are properly and aptly executed.
• The candidate will also be expected to analyze the data collected and present the results in formal presentations, manuscripts, and grant applications.

Specific criteria include:

• Effective knowledge - Knowledge of lab practices and procedures in animal handling, dissection, Western blotting, PCR, fluorescence imaging, sub-cloning, and transfection.
• Accountability & Self-Management - Work independently, with minimal supervision by PI. Perform routine duties using established procedures with coordination and effective communication with the PI.
• Teamwork & Leadership - Independently develop and implement laboratory policies, update standard operating procedures that should ensure safe practices for all laboratory members.
• Communication - Communicate effectively with PI and other laboratory members as the projects are executed. Excellent verbal and written communication required for manuscript and grant preparation.
• Innovation & Problem Solving - Will contribute to the optimization of experimental procedures that require novel approaches.

Education Requirements:

The successful candidate will possess a doctoral degree with expertise in molecular biology, experience with in-vivo and in-vitro models of inflammation testing, and experience with flow cytometry.

Experience with cell culture techniques and demonstrated ability to isolate and culture primary cells is essential.

Background checks/certifications

Employment with the University will require successful completion of background check(s) in accordance with University policies.

Benefits

Penn State provides a competitive benefits package for full-time employees designed to support both personal and professional well-being.

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Pursuant to the Jeanne Clery Disclosure of Campus Security Policy and Campus Crime Statistics Act and the Pennsylvania Act of 1988, Penn State publishes a combined Annual Security and Annual Fire Safety Report (ASR). The ASR includes crime statistics and institutional policies concerning campus security, such as those concerning alcohol and drug use, crime prevention, the reporting of crimes, sexual assault, and other matters. The ASR is available for review here.

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Penn State is an equal opportunity employer and is committed to providing employment opportunities to all qualified applicants without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability or protected veteran status. If you are unable to use our online application process due to an impairment or disability, please contact 814-865-1473.

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