Post Doctoral Fellow - Pharmacological & Pharmaceutic Department - (497013 )

University of Houston; Houston (TX); On-site; USD 52,000 - 68,000; Full time

Job summary

The Vedagopuram Research Group at the University of Houston College of Pharmacy seeks a highly motivated postdoctoral fellow to join a newly established, growing research program. Dr.

Sreekanth Vedagopuram is an Assistant Professor of Medicinal Chemistry in the Department of Pharmacological and Pharmaceutical Sciences at UH. Our work spans three areas: bifunctional molecules, chemical control of genome-editing proteins, and delivery platforms for macromolecules.

Qualifications

• PhD in chemistry, chemical biology, biochemistry, cell biology, biotechnology, or related field.
• Foundational skills in synthetic chemistry and/or molecular biology or protein biochemistry.
• Excellent communication and teamwork skills.
• Strong work ethic and enthusiasm for scientific research.

Responsibilities

• Receive, review progress and evaluate results of experiments under supervision.
• Develop and execute research plans for bifunctional molecules and genome-editing control.
• Collaborate across chemistry, biology, and pharmacology teams to drive projects.
• Lead experimental design, data interpretation, and troubleshooting.
• Contribute to grant writing, publications, and project management.

Skills

Synthetic chemistry

Molecular biology

Protein biochemistry

Communication skills

Teamwork

Laboratory leadership

Education

PhD in chemistry or related field

Postdoctoral experience preferred

Tools

CRISPR-Cas9

Protein expression

Purification methods

Biochemical assays

Job description

Department: Pharmacological &PharmaceuticSalary: Commensurate withExperience/Education

Description

Possesses, understands, and applies a comprehensive knowledge inarea of specialization. Develops understanding and skills to allowfor completion of assignments that cross fields of specialization.Develops leadership and management skills. 1. Receives/Reviews progress and evaluates results of experimentsor projects under control or supervisory responsibility. 2. Recommends changes in research, testing or experimentalprocedures. 3. May be responsible for a single highly technical and complexpiece of research equipment. 4. May review and evaluate the effectiveness of personnel. 5. May plan for and assign personnel to projects undercontrol. 6. Operates with latitude for unreviewed action. 7. May receive general supervision conferring with higher levelsonly in unusual situations. 8. Performs other job-related duties as required. The Vedagopuram Research Group at the University of Houston Collegeof Pharmacy seeks a highly motivated postdoctoral fellow to join anewly established, growing research program.

Dr. Sreekanth Vedagopuram is an Assistant Professor of MedicinalChemistry in the Department of Pharmacological and PharmaceuticalSciences at the College of Pharmacy, University of Houston.

Current Research Areas

Our lab develops bifunctional molecules that induce or modulatepost-translational modifications to probe and control biomolecularfunction. We combine chemical biology, CRISPR technology, and drugdelivery to uncover molecular mechanisms and new therapeuticstrategies.

Our work spans three areas:

1. Bifunctional small molecules, including degraders and(de)phosphorylating molecules that control protein function
2. Chemical control of genome-editing proteins
3. Delivery platforms that shuttle therapeutic macromolecules intotarget cells.

Areas of Interest

• Chemical biology and targeted protein degradation
• Induced-proximity technologies
• Medicinal and synthetic chemistry
• CRISPR-Cas9 genome editing and transcription control
• Protein engineering
• Drug and macromolecule delivery

Qualifications

Applicants should possess:

• A Ph.D. in chemistry, chemical biology, biochemistry, cellbiology, biotechnology, pharmaceutical sciences, or a relatedfield
• Strong foundational skills in synthetic chemistry, [or] molecularand cell biology, and/or protein biochemistry
• Excellent communication and teamwork skills.
• A strong work ethic and enthusiasm for scientific research

Experience with one or more of the following is desirable,but not required:

1. Synthetic/ medicinal chemistry: Experience with organicsynthesis, small-molecule design, and structure-activityrelationship studies. Candidates with a chemistry background whoare interested in learning cell and molecular biology arepreferred.
2. Protein engineering: Experience with protein expression,purification, and engineering, including fusion constructs orbioconjugation
3. Molecular biology and CRISPR/ genome editing: Experience withCRISPR-Cas9 systems, genome-editing assays in mammalian cells, andvarious cloning techniques.
4. Biochemistry and assay development: Experience developing assaysto probe post-translational modifications, protein-proteininteractions, or induced-proximity systems. Experience withstandard biochemical techniques (e.g., Western blotting,co-immunoprecipitation, enzymatic assays)
5. Cell culture: Experience with mammalian cell culture,transfection, dose-response assays, ternary complex assays.
6. Drug/ macromolecule delivery: Experience with delivery platformsfor nucleic acids, proteins, or other macromolecular cargo.

Successful candidates should be highly motivated, intellectuallycurious, and committed to pursuing innovative and impactfulresearch.

MQ: Requires singular knowledge of a specialized advancedprofessional discipline or the highest level of general businessknowledge, normally acquired through attainment of a directlyjob-related terminal degree or equivalent formal training in arecognized field of specialization that is directly related to thetype of work being performed.

No experience is required.

All positions at the University of Houston-System are securitysensitive and will require a criminal history check.

The University of Houston System and its universities are EqualOpportunity Institutions. Everyone is encouraged to apply.