Post Doc, R&D Immunology - Population Analytics & Insights

Johnson & Johnson Innovative Medicine; Spring House (PA); On-site; USD 79,000 - 128,000; Full time

Benefits offered by this job

Vacation time 120 hours/year

Sick time 40 hours/year

Parental Leave

Job summary

Johnson & Johnson Innovative Medicine (JJIM) is recruiting a Postdoctoral Scholar to work within the Data Sciences group on drug target identification and evaluation to support Immunology priorities.

The Data Science Analytics & Insights team develops innovative solutions from diverse data sources to advance our drug discovery pipeline, enabling translational insights across clinical and molecular dimensions.

Qualifications

• PhD in quantitative field with strong biology basis (Bioinformatics, Computational Biology, Systems Biology, Statistical Genetics or related).
• Completed PhD program.
• Experience with multi-omic data (RNA expression, proteomics, epigenomics, genetics) at bulk and single-cell levels.
• Working knowledge of gene/pathway ontology databases and network analysis.
• Proficient in programming and collaborating in a team to meet objectives on timelines.
• Independent, self-motivated, innovative and able to excel in a fast-moving team.
• Excellent communication and leadership with track record of publications.

Responsibilities

• Develop analytic framework by integrating perturbation, ontology and cellular phenotyping with omics datasets to enhance target evaluation and patient stratification.
• Apply inference and ML methods to link targets to disease pathways and predict toxicity.
• Model multimodal data to predict target pathway activity and synergistic effects.
• Analyze phenomic, multiomic and biobank data to identify targets and biomarkers for immune-mediated diseases.
• Provide design and analysis guidance for immunology colleagues and collaborate across the organization.
• Translate computational findings to functional and pharmacological validation.

Skills

PhD required

Multi-omics data

Bioinformatics

Programming

Independent worker

Communication skills

Education

PhD

Tools

NLP

ML/AI

LLM

Job description

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

Learn more at jnj.com

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function

Career Programs

Job Sub Function

Post Doc – R&D Product Development

Job Category

Career Program

All Job Posting Locations

Spring House, Pennsylvania, United States of America

Job Description

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

Johnson and Johnson Innovative Medicine (JJIM) is recruiting a Postdoctoral Scholar to work within the group (Data Sciences organization) on drug target identification and evaluation to support alignment of priorities with the Immunology therapeutic area.

The Data Science Analytics & Insights organization develops innovative solutions using a variety of data sources across multiple different disease\areas. We are looking for a highly motivated and self-driven individual who will creatively analyze large-scale clinical, genetic, omics and cell phenotype data to advance our drug discovery pipeline in R&D.

At J&J, we strive to bring in the brightest minds in pursuit of developing effective and safe therapeutics for patients around the globe.

Role & Responsibilities

• Construct an analytic framework by integrating perturbation, ontology and cellular phenotyping with molecular based datasets including genomics, transcriptomics, proteomics, to further enhance target evaluation, and patient stratification.
• Use multiple inference and ML methods linking molecular targets to disease states/characteristics, to associate targets with disease pathways, and to validate predicted mechanisms systematic on-/off-target toxicity predictions. These approaches require innovative computational methods such as network-based models, machine learning, and novel algorithmic approaches to mining biological data.
• Provide scientific technical expertise in modeling multimodal data (including genetic, transcriptomics, proteomic and functional data) to predict target pathway activity and synergistic effects.
• Apply or develop a wide variety of statistical modeling and AI/ML methods to analyze phenomic, multiomic and biobank level data to identify targets associated therapeutic with clinical and/or molecular segments and biomarkers associated with immune mediated diseases.
• Provide design and analysis consultation for questions of interest to our Immunology colleagues and facilitate interactions between colleagues across the organization.
• Translate findings from computational analyses to support functional, biological and pharmacological validation.

Job Qualifications

Required skills

• A Ph.D. in a quantitative field with a strong biological basis – Bioinformatics, Computational Biology, Systems Biology, Statistical Genetics, or related fields.
• Completed PhD program.
• Experience with multi-omic data (RNA gene expression, proteomics, epigenomics, genetics) at both bulk and single cell level.
• Working knowledge of databases and analytic approaches associated with gene/pathway ontology, such as network analysis.
• Proficient in programming and computational skills and demonstrated ability to work with a group of scientists to deliver on objectives in defined timelines.
• Independent, self-motivated, innovative, and able to excel in a goal-oriented, multifaceted and fast-moving team environment.
• Outstanding communication, organizational and leadership skills, with a successful track record of publication and collaboration with cross-functional scientific teams.

Preferred Skills

• Experience working with Immunology projects.
• Expertise in perturbation data and analysis.
• Experience with advanced analytical approaches (NLP, ML/AI, LLM) to extracting relevant sources of annotation of cellular states, functions and localization from unstructured data.
• Experience with predictive models associated with evaluation of target engagement and druggability.
• Experience with drug discovery and development practices and project support in a large pharmaceutical setting.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected under federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center ([e-mail]) or contact AskGS to be directed to your accommodation resource.

The anticipated base pay range for this position is :

$79,000.00 - $127,650.00

Additional Description For Pay Transparency

ubject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).

For additional general information on Company benefits, please go to: - https://www.careers.jnj.com/employee-benefits

Benefits

• Vacation –120 hours per calendar year
• Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
• Holiday pay, including Floating Holidays –13 days per calendar year
• Work, Personal and Family Time - up to 40 hours per calendar year
• Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
• Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
• Caregiver Leave – 80 hours in a 52-week rolling period10 days
• Volunteer Leave – 32 hours per calendar year
• Military Spouse Time-Off – 80 hours per calendar year
• For additional general information on Company benefits, please go to: - https://www.careers.jnj.com/employee-benefits