PK/PD Senior Scientist

Scorpion Therapeutics; Michigan; On-site; USD 114,000 - 185,000; Full time

Benefits offered by this job

Healthcare from day one

401(k) match and profit-sharing

4 weeks vacation

Job summary

Scorpion Therapeutics is seeking a Ph.D.-level scientist to design and analyze in vivo PK/PD studies across veterinary species, writing protocols and reports. You will provide PK/PD modeling to optimize dose regimens and help select lead candidates.

You will collaborate with bioanalytical teams, lead mechanistic strategy across therapeutic areas, and communicate results to regulatory agencies. A strong background in biotherapeutics is highly desirable.

Qualifications

• Ph.D. in pharmacology, pharmaceutical sciences, biochemistry, or related field.
• 2–4 years post-doctoral experience in pharmaceutical development is desirable; DVM DACVCP or DVM Dipl. ECVPT desirable.
• Proven ability to design, analyze, and interpret in vivo PK/PD studies; biotherapeutics experience is desirable.

Responsibilities

• Design and analyze in vivo PK/PD, PK and TK studies across species; write protocols and reports.
• Provide PK/PKPD modeling to select lead candidates and optimize dosing.
• Collaborate with bioanalytical team to assess assays and forecast requirements.
• Lead scientific strategy across therapeutic areas with mechanistic biomarkers.
• Work with multidisciplinary teams to design and prosecute studies per direction.
• Present research results to teams, management, and regulatory agencies.
• Write sections of regulatory submissions and respond to inquiries.

Skills

PK/PD analysis software

Verbal and written communication

Self-starter

Bioanalytical knowledge

PK/PD modeling & simulation

Education

Ph.D. in pharmacology/pharmaceutical sciences/biochemistry or related

Tools

WinNonlin

Monolix

Watson

Job description

POSITION RESPONSIBILITIES:

• Design and analyze in vivo PK/PD, PK and TK studies in multiple veterinary species, including writing study protocols and reports.
• Provide PK and PK/PD modeling and simulation to help select lead candidates and optimize dose regimens.
• Collaborate with bioanalytical team to assess suitability of analytical assays and forecast analytical requirements for projects.
• Lead development of scientific strategy across therapeutic areas with a focus on mechanistic platforms/biomarkers to aid translation, measurement of target engagement, and dose regimen predictions.
• Work collaboratively and communicate effectively with multidisciplinary teams to design and prosecute studies in line with project direction.
• Present research results to scientific teams, management, and regulatory agencies.
• Write sections of regulatory submissions, respond to regulatory inquiries, and maintain knowledge of regulatory guidance.

REQUIRED EDUCATION AND EXPERIENCE:

• Ph.D. in pharmacology, pharmaceutical sciences, biochemistry, or related field.
• 2–4 years post-doctoral experience in pharmaceutical development is highly desirable; DVM DACVCP or DVM Dipl. ECVPT is highly desirable.
• Proven ability to design, analyze, and interpret in vivo PK and PK/PD studies; biotherapeutics (protein therapeutics) experience is highly desirable.

REQUIRED SKILLS:

• Proficiency with PK/PKPD analysis software such as WinNonlin, Monolix, or Watson.
• Excellent verbal and written communication.
• Self-starter who can prioritize and work efficiently with minimal supervision.
• Working knowledge of bioanalytical methodology.
• PK/PD modeling and simulation (PBPK, QSP, population PK using NONMEM, R, or related) is highly desirable.

Benefits/compensation (if explicitly stated):

• US base salary range: $114,000–$185,000; eligible for short-term and long-term incentives.
• Healthcare/insurance beginning day one, 401(k) match and profit-sharing, and 4 weeks vacation.
• Visit zoetisbenefits.com to learn more.