PK/PD Principal Scientist

Zoetis; Michigan; On-site; USD 114,000 - 185,000; Full time

Benefits offered by this job

Short-term incentive

Long-term incentives

Healthcare benefits

401K with match

Paid vacation

Job summary

Zoetis in the United States seeks an enthusiastic colleague to join our Veterinary Medicine Research and Development PK/PD Scientist Team to discover and develop novel therapeutics for veterinary medicine. The successful candidate will lead in vivo PK/PD studies across multiple species and collaborate with cross-functional teams to advance projects from early research through late-stage development.

The role requires a PhD with strong PK/PD modeling, regulatory experience, and excellent

Qualifications

• Ph.D in pharmacology, biochemistry, or related field with 4+ years of pharma development experience.
• Experience designing, analyzing and interpreting in vivo PK/PD studies; biotherapeutics desirable.
• Proficient with PK/PD software: WinNonlin, Monolix, Watson.
• Excellent verbal and written communication skills.
• Self-starter with ability to prioritize and work with minimal supervision.
• Knowledge of bioanalytical methods.
• ADA assays and immunogenicity of biotherapeutics desirable.
• PK/PD modeling using NONMEM, R, PBPK, QSP, etc.
• Experience interacting with regulatory agencies and GLP studies desirable.

Responsibilities

• Independently design and analyze in vivo PK/PD, PK and TK studies in multiple veterinary species; write study protocols and reports.
• Provide PK and PK/PD modeling and simulation to help select lead candidates and optimize dose regimens.
• Collaborate with bioanalytical team to assess assay suitability and forecast analytical requirements.
• Lead development of scientific strategy focusing on biomarkers and target engagement.
• Work with multidisciplinary teams to design and prosecute studies in line with project direction.
• Present research results to scientific teams, management, and regulatory agencies.
• Write sections of regulatory submissions and respond to inquiries.

Skills

PK/PD analysis

Team collaboration

Scientific communication

Independent leadership

Education

Ph.D. in pharmacology, biochemistry, or related field

Tools

WinNonlin

Monolix

NONMEM

R

Watson

Job description

Zoetis, a global leader in animal health, seeks an enthusiastic colleague to join our Veterinary Medicine Research and Development (VMRD) PK/PD Scientist Team to discover and develop novel therapeutics for veterinary medicine. The successful candidate will be primarily responsible for designing, conducting, analyzing, and interpreting in vivo PK/PD studies in multiple species in support of projects from early research through late-stage development. This position will require a highly motivated and independent leader who can effectively collaborate with other team members to advance projects.

POSITION RESPONSIBILITIES:

• Independently design and analyze in vivo PK/PD, PK and TK studies in multiple veterinary species, including writing study protocols and reports.
• Provide PK and PK/PD modeling and simulation to help select lead candidates and optimize dose regimens.
• Collaborate with bioanalytical team to assess suitability of analytical assays and forecast analytical requirements for projects.
• Lead development of scientific strategy across therapeutic areas with a focus on mechanistic platforms/biomarkers to aid in translation, measurement of target engagement, and dose regimen predictions.
• Work collaboratively and communicate effectively with multidisciplinary teams to design and prosecute studies in line with the strategic direction of the project.
• Present research results to scientific teams, management, and regulatory agencies.
• Write sections of regulatory submissions, respond to inquiries from regulatory agencies, and maintain knowledge of regulatory guidance documents.

REQUIRED EDUCATION AND EXPERIENCE:

• Ph.D in pharmacology, biochemistry, or related field with 4 or more years of relevant pharmaceutical development experience. DVM DACVCP or DVM Dipl. ECVPT is highly desirable.
• Proven ability to design, analyze and interpret in vivo PK and PK/PD studies. Experience with biotherapeutics (protein therapeutics) is highly desirable.
• Skilled in the use of PK and PK/PD analysis software such as WinNonlin, Monolix or Watson.
• Must have excellent verbal & written communication skills.
• Self-starter, able to prioritize work and work efficiently with minimal supervision.
• Working knowledge of bioanalytical methodology.
• Knowledge of ADA assays and assessment of immunogenicity of biotherapeutics is highly desirable.
• Experience in PK/PD modeling and simulation such as PBPK, QSP or population PK modeling using NONMEM, R, or related software is highly desirable.
• Experience interacting with regulatory agencies is highly desirable.
• Experience conducting GLP studies is desirable.

The US base salary range for this full-time position is $114,000 - $185,000. Our salary ranges are determined by role, level, and location. The range displayed on each job posting reflects the base pay target range for new hire salaries for the position. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training.

Benefits and Incentives:

• This position is also eligible for short-term incentive compensation
• This position is also eligible for long-term incentives
• In addition to compensation, Zoetis offers a comprehensive benefits package that supports the physical, emotional and financial wellbeing of our colleagues and their families including healthcare and insurance benefits beginning
• on day one, a 401K plan with a match and profit-sharing contribution from Zoetis, and 4 weeks of vacation.

Visit zoetisbenefits.com to learn more.

About Zoetis

At Zoetis, our purpose is to nurture the world and humankind by advancing care for animals. As a Fortune 500 company and the world leader in animal health, we discover, develop, manufacture and commercialize vaccines, medicines, diagnostics and other technologies for companion animals and livestock. We know our people drive our success. Our award-winning culture, built around our Core Beliefs, focuses on our colleagues' careers, connection and support. We offer competitive healthcare and retirement savings benefits, along with an array of benefits, policies and programs to support employee well-being in every sense, from health and financial wellness to family and lifestyle resources.