Organic and Conjugation Chemist

Initial Therapeutics, Inc.; Thousand Oaks (CA); On-site; USD 80,000 - 100,000; Full time

Benefits offered by this job

Comprehensive employee benefits package

Retirement and Savings Plan

Flexible work models

Job summary

Amgen is seeking a highly motivated Senior Associate Organic and Conjugation Chemist to join the Hybrid Modality Group in Thousand Oaks, California. You will perform multistep organic synthesis, purify small molecules, and learn bioconjugation techniques in a state-of-the-art research facility.

The role requires a strong background in organic synthesis, excellent communication skills, and the ability to work within a diverse team. You can expect a comprehensive benefits package and support for professional growth.

Qualifications

• Master's Degree or equivalent experience in relevant field.
• Strong background in organic synthesis and purification techniques.
• Ability to document scientific data accurately.

Responsibilities

• Perform multistep organic synthesis of linker‑payload reagents.
• Purify and characterize small molecules.
• Learn and perform bioconjugation of antibodies and peptides.

Skills

Organic synthesis

Analytical methods

Chemical conjugation

Communication skills

Team collaboration

Education

Master's Degree

Bachelor's Degree and 2+ years of relevant experience

Associates degree and 4 years of relevant experience

High school diploma / GED and 6 years of relevant experience

Job description

Senior Associate Organic and Conjugation Chemist

The Hybrid Modality Group at Amgen is seeking a highly motivated scientist in the field of Antibody Drug Conjugates (ADC) to join us in the state‑of‑the‑art research facility at the Amgen headquarters campus located in Thousand Oaks, CA. The qualified candidate will work at the interface of synthetic chemistry, biochemistry, and chemical biology, and apply their chemical synthesis skills in developing new antibody drug conjugates to support the advancement of drug discovery programs.

Responsibilities include:

• Perform multistep organic synthesis of linker‑payload reagents under supervision
• Purify and characterize small molecules using techniques such as flash chromatography, HPLC, LC/MS, and NMR.
• Learn and perform bioconjugation of antibodies, peptides, and small molecule payloads and characterize conjugates using analytical techniques, such as HPLC, LC‑MS, and SEC
• Document experimental plans and procedures in electronic lab notebooks while following appropriate SOPs.
• Generate, analyze and summarize scientific data and provide regular updates on project results.
• Operate and maintain standard lab equipment

Basic qualifications

• Master's Degree
• Bachelor's Degree and 2+ years of relevant experience
• Associates degree and 4 years of relevant experience
• High school diploma / GED and 6 years of relevant experience

Preferred qualifications

• Experienced in organic synthesis including executing and optimizing chemical reactions
• Basic understanding of purification and analytical methods
• Eagerness to learn chemical conjugation and characterization of ADC
• Demonstration of good lab practices, with particular attention to safety
• Strong written and verbal communication skills
• Ability to work comfortably within a dynamic team of scientists and engineers with diverse technical and cultural backgrounds

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well‑being. From our competitive benefits to our collaborative culture, we support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan
• Stock‑based long‑term incentives
• Award‑winning time‑off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Sponsorship for this role is not guaranteed.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.