Oncology Research Scientist - Organoids & Animal Models

St. Jude Children's Research Hospital; Memphis (TN); Presencial; USD 86.000 - 155.000; Jornada completa

Descripción de la vacante

St. Jude Children’s Research Hospital’s dos Santos laboratory in the Oncology department seeks an Associate Scientist or Scientist to lead animal-model and organoid-based cancer research.

The role involves independent project management, experimental design, data analysis, and ensuring high reproducibility and animal welfare. The candidate will work with the PI, trainees, and shared-resource teams to advance studies on cancer initiation, epithelial–stromal interactions, and systemic risk

Formación

• Bachelor's degree in cancer biology, cell biology, molecular biology, developmental biology, biomedical sciences, or related field is required.
• PhD or equivalent doctoral degree strongly preferred.

Responsabilidades

• Design, coordinate, and execute studies using engineered, syngeneic, transplantation, and treatment-based mouse models of mammary gland biology and breast cancer.
• Manage mouse breeding strategies, cohort generation, genotyping plans, randomization, and longitudinal monitoring.
• Perform or supervise animal procedures and tissue collection.
• Develop and maintain detailed experimental timelines and animal-cohort records.
• Assist with IACUC protocol preparation and amendments.
• Ensure compliance with animal welfare policies, biosafety requirements, and approved procedures.
• Train laboratory personnel in relevant animal procedures and confirm competency.
• Establish and optimize primary mammary epithelial and tumor organoid cultures from mouse and human samples.
• Design organoid assays evaluating growth, differentiation, and drug response.
• Develop co-culture systems with fibroblasts, immune cells, and ECM components.
• Perform organoid-forming, invasion, and viability assays.
• Conduct molecular and cellular assays: flow cytometry, immunofluorescence, IHC, microscopy, qPCR, ELISA.
• Support preparation of bulk and single-cell sequencing and spatial profiling samples.
• Maintain detailed, accurate, and reproducible experimental records.
• Collaborate with PI to develop strategies, priorities, and assess feasibility.
• Analyze data with appropriate statistics and computational methods.
• Present findings in lab meetings and seminars.
• Promote collaboration within the lab and with external partners.

Conocimientos

Mouse models

Primary cell culture

Organoids

Experimental design

Data interpretation

Troubleshooting

Oral communication

Educación

Bachelor's degree in life sciences

PhD preferred

Descripción del empleo

St. Jude Children’s Research Hospital’s dos Santos laboratory in the Oncology department seeks an Associate Scientist or Scientist to lead animal-model and organoid-based cancer research.

The role involves independent project management, experimental design, data analysis, and ensuring high reproducibility and animal welfare. The candidate will work with the PI, trainees, and shared-resource teams to advance studies on cancer initiation, epithelial–stromal interactions, and systemic risk