Neuroimaging Analytics Specialist

CHDI Management; Princeton (NJ); Hybrid; USD 115,000 - 145,000; Full time

Benefits offered by this job

COVID-19 vaccination prerequisite

Job summary

CHDI Foundation is expanding its neuroimaging analytics program to accelerate biomarker discovery for Huntington’s disease. We seek a scientist with MRI and/or PET data analytics, quantitative image processing, and applied deep learning to design and implement data pipelines and AI methods.

The role involves overseeing data handling across imaging modalities, building reproducible pipelines, and deploying AI-driven approaches for biomarker discovery and multi-site harmonization.

Qualifications

• MS or BA in a quantitative field and 3+ years of medical imaging data analysis.
• Proficiency in Python, MATLAB, or R and AI/ML frameworks (PyTorch, TensorFlow).
• Experience with neuroimaging packages (FreeSurfer, FSL, SPM, ANTs, Nipype) and data standards (DICOM, BIDS).

Responsibilities

• Develop robust data pipelines for MRI and PET data ingestion, curation, de-identification, BIDS conversion, and QC across sites.
• Develop algorithms for brain segmentation, tissue classification, harmonization, denoising, and anomaly detection.
• Handle dynamic imaging data and 4D data analysis.
• Model PET tracer quantification (SUVR, DVR, binding potential) and dynamic data.
• Apply ML/DL for biomarker extraction and predictive modeling.
• Cross-modality data fusion and multi-site harmonization.
• Prepare technical reports and visualizations for reviews and collaborations.

Skills

MRI analytics

PET analytics

Quantitative image processing

Deep learning

Python

MATLAB

R

AI/ML frameworks

Education

MS or BA in a quantitative field

Tools

FreeSurfer

FSL

SPM

ANTs

PMOD

Nipype

DICOM

BIDS

PyTorch

TensorFlow

Job description

Title: Neuroimaging Analytics Specialist

Location: Princeton, NJ- 2 days per week in office requirement.

Reports To: Vice President, Clinical Neuroimaging Research

Salary Range: $115,000 – $145,000 Exact compensation will vary based on experience

Other: Vaccination against COVID-19 is a prerequisite for employment at CHDI Management

About CHDI Foundation, Inc.

CHDI Foundation, Inc. is a privately funded nonprofit biomedical research organization exclusively dedicated to collaboratively developing therapeutics that will substantially improve the lives of those affected by Huntington’s disease (HD). CHDI has assembled a team of scientists and other professionals working in offices located in Los Angeles, New York City, and Princeton, NJ. Our scientists work closely with a network of more than 700 researchers in academic and industrial laboratories around the world in the pursuit of these novel therapies, providing strategic scientific direction to ensure that our common goals remain in focus.

CHDI works to increase the understanding of HD in order to hasten the development of therapeutic approaches. To achieve this goal, CHDI manages a diverse portfolio of research projects through a novel virtual model that encourages scientific collaboration, one which more directly connects academic research, drug discovery and clinical development. This helps bridge the translational gap that often exists between academic and industrial research pursuits and that adds costly delays to therapeutic development. In its role as a collaborative enabler, CHDI seeks to bring the right partners together to identify and address critical scientific issues and move drug candidates to clinical evaluation as rapidly as possible. Our activities extend from exploratory biology to the identification and validation of therapeutic targets, and from drug discovery and development to clinical studies and trials. More information about CHDI can be found at www.chdifoundation.org

Position Summary

CHDI Foundation is expanding its neuroimaging analytics capabilities to accelerate the development of imaging biomarkers for Huntington’s disease (HD). We are seeking a highly motivated scientist with expertise in MRI and/or PET data analytics, quantitative image processing, and applied deep learning. This position will design and implement advanced data management pipelines, algorithm development, and artificial intelligence (AI) methods for structural and quantitative MRI, and PET imaging. The scientist will oversee data handling, algorithm development, and quantitative analysis across imaging modalities to establish analysis-ready datasets for integration into CHDI’s neuroimaging studies and biomarker development strategies. The successful candidate will build reproducible pipelines, and deploy novel and AI-driven approaches to improve biomarker discovery, harmonization, and predictive modeling across multi-site datasets.

Key Responsibilities

• Develop and manage robust data pipelines for MRI and PET data ingestion, curation, de-identification, BIDS conversion, and QC across imaging studies and study sites.


• Implement and optimize software, algorithms, DL and AI based tools for:
  
  
  
  • Structural and quantitative MRI brain segmentation, tissue classification, image harmonization, denoising, and anomaly detection.
  
  
  • Dynamic and multi-dimensional imaging data handling, 4D data analysis.
  
  
  • Parametric and kinetic modeling of PET data for tracer quantification (SUVR, DVR, binding potential, and dynamic data modeling)
  
  
  • Predictive modeling and biomarker extraction using machine learning and deep neural networks (CNNs, 3D U-Nets, etc.).
  
  
  
  


• Develop algorithms for cross-modality data fusion and multi-site harmonization.


• Collaborate with site investigators and CHDI’s data management and biomarker teams to establish scalable data transfer and analysis workflows.


• Prepare data documentation, technical reports, visualizations, and presentations for internal reviews, publications, and external collaborations.

Qualifications

• M.S. or B.A. in Electrical/Biomedical Engineering, Computer Science, Mathematics, Physics, Neuroscience, Data Science, or related quantitative discipline.


• 3+ years of hands-on experience in medical imaging data analysis, including image reconstruction, segmentation, registration, and quantitative image analysis.


• Proficiency in Python, MATLAB, and/or R; with programming and AI/ML expertise; experience with AI/deep learning frameworks such as PyTorch, TensorFlow, etc.


• Experience with neuroimaging software packages (FreeSurfer, FSL, SPM, ANTs, PMOD, Nipype) and data standards (DICOM, BIDS, etc.).


• Strong background in machine learning, image processing; algorithm development.


• Proven ability to manage and analyze large, multi-site imaging datasets, ensuring data integrity and reproducibility.


• Experience applying AI/DL for neuroimaging, including segmentation, harmonization, or anomaly detection.

About CHDI Foundation, Inc.

CHDI Foundation is a private nonprofit biomedical research organization exclusively dedicated to collaboratively developing therapeutics that will substantially improve the lives of those affected by Huntington’s disease (HD).

About CHDI Management, Inc.

Our staff works for CHDI Management, Inc., which was established in 2002 to provide administrative and management services to CHDI Foundation, Inc.

About our Donors

CHDI’s activities focus solely on the collaborative development of therapeutics that will substantially improve the lives of those affected by Huntington’s disease. We are indebted to our donors, whose generosity and guidance have made possible this exclusive focus on science.