mRNA Analytical Development Scientist - Analytical Sciences

BioSpace; Waltham (MA); On-site; USD 120,000 - 180,000; Full time

Job summary

Sanofi Pasteur is seeking an mRNA Analytical Development Scientist to strengthen the Analytical Sciences group in R&D. The role focuses on developing and validating robust LC-MS based methods for mRNA vaccine characterization, supporting release and stability testing, and collaborating with CMC teams.

The candidate should have PhD or MSc with pharma/biotech analytical experience and a track record in method development and complex experiments, with strong writing skills for regulatory filings.

Qualifications

• PhD or MSc with pharma/biotech analytical experience.
• Experience in characterizing proteins, oligonucleotides, lipids and degradants via LC-MS.
• Ability to develop and improve complex analytical methods.

Responsibilities

• Develop advanced biochemical and biophysical assays, focusing on LC-MS characterization for mRNA vaccine process.
• Collaborate with analytical leads to support CMC activities.
• Write and review method documentation and characterization reports for regulatory filings.
• Design and execute complex experiments independently, and report results.
• Support QC and CRO investigations, deviations, and change control.
• Train junior team members and promote lab safety and quality compliance.

Skills

LC-MS characterization

Analytical method development

Biochemical & biophysical assays

Team collaboration

Education

PhD in Analytical Chemistry / Biochemistry / Biotechnology

MSc in Analytical Chemistry / Biochemistry / Biotechnology

Tools

LC-MS instruments

Job description

Job title: mRNA Analytical Development Scientist - Analytical Sciences

• Location: Waltham, MA

About The Job

In order to strengthen the Biochemical and Biophysical group in R&D Analytical Sciences Department, Sanofi Pasteur is looking for a skilled and highly motivated individual to develop novel methods and improve characterization of mRNA vaccines in development by working closely with the bioprocess development group.

Analytical Sciences Department has the overall responsibility to develop, qualify and validate robust analytical methods to support release and characterization testing of mRNA Drug Substances and Drug Products candidates in development.

In the race for the future of healthcare Sanofi mRNA Center of Excellence

At Sanofi, we believe in a world in which no one suffers or dies from vaccine-preventable diseases. The pandemic has sustainably transformed our industry, creating new opportunities and challenges. At Sanofi, we are convinced that accelerating the innovation of mRNA technology means better vaccine accessibility for all populations, faster than before.

For this reason, we are looking for bold, optimistic collaborators for our new team at the mRNA Center of Excellence. We are investing 400 million in this brand new centre, where 400 employees dedicated to this technology work.

This center of excellence is proof of our commitment to the development and acceleration of vaccination and research resources with the R&D, digital and CMC teams.

The future of Sanofi depends on your ambition, your commitment. Join.

Join the engine of Sanofis mission where deep immunoscience meets bold, AI-powered research. In R&D, youll drive breakthroughs that could turn the impossible into possible for millions.

About Sanofi

Were an R&D-driven, AI-powered biopharma company committed to improving peoples lives and delivering compelling growth. Our deep understanding of the immune system and innovative pipeline enables us to invent medicines and vaccines that treat and protect millions of people around the world and are supported and enhanced through our diverse portfolio of medical device and diagnostic products. Together, we chase the miracles of science to improve peoples lives.

Main Responsibilities

• Develop advanced technology for biochemical and biophysical assay development, primarily focusing on LC-MS characterization, in support of mRNA vaccine process and product development, product release, stability, and comparability study.
• Work with analytical leads supporting CMC activities.
• Write and review method documentation and characterization reports in support of regulatory filings.
• Ensure timely completion of assignments and deliverables. Independently design and execute complex experiments under general supervision. Author method development and investigation reports.
• Support QC and/or CROs on investigations, deviations, and change control.
• Participate internal non-GMP and GMP lab set up and product release and stability testing.
• Provide training to junior team members.
• Compliant to Sanofi Quality standards and HSE policy. Participate in continuous improvement of laboratory safety and quality compliance.

About You

Basic Qualifications

• PhD or Master's degree (MSc) in Analytical Chemistry, Biochemistry, Biotechnology, or related sciences
• PhD holders: Minimum 1 year of pharma/biotech industry experience in analytical development and/or quality control
• MSc holders: Minimum 4 years of pharma/biotech industry experience in analytical development and/or quality control
• Expertise and extensive hands-on experience in the analyses and characterization of proteins, oligonucleotides, lipids and their degradants using LC-MS.
• Ability to perform complex method development and propose appropriate method improvement.

Preferred Qualifications

• Hands-on experience and comprehensive knowledge in other biochemical and biophysical techniques, including but not limited to LC (RP, IEX, SEC, HILIC), CGE, cIEF, spectroscopy, particle analysis, etc.
• Knowledge of nucleic acid/oligonucleotides chemistry and standard analytical methods of these molecules.
• Experienced in working with highly technical projects with reactivity.

Skills And Competencies

• Excellent verbal and written communication skills.
• Able to work independently and collaborate in a team; enthusiastic and self-motivated. Agility to respond to urgent requests, and initiative to lead new tasks.
• Ability to work full time onsite in an analytical lab environment.

Why choose us?

• Bring the miracles of science to life alongside a supportive, future-focused team.
• Discover endless opportunities to grow your talent and drive your career, whether its through a promotion or lateral move, at home or internationally.
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks gender-neutral parental leave.
• Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs.
• Help improve the lives of millions of people globally by making drug development quicker and more effective.
• Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.

Sanofi US Services and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.