MRICD Neuroscience Research Opportunity
Oak Ridge Institute for Science and Education
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Benefits offered by this job
Job summary
Oak Ridge Institute for Science and Education (ORISE) at USAMRICD, Aberdeen Proving Ground, MD, invites current or recent graduates with BS/MS/PhD in Neuroscience, Physiology, Pharmacology or Toxicology to engage in in vivo studies identifying therapeutics against chemical threat agents. Under mentorship, you will perform in vivo pharmacology/toxicology experiments, cell culture, ex vivo approaches, and immunohistochemistry, while contributing to manuscript preparation and grant writing.
U.S.
Qualifications
- Eligible candidates are pursuing or possess a Bachelor's, Master's or Doctoral degree in Neuroscience, Physiology, Pharmacology, Toxicology or related STEM field.
- Degree must have been received within 5 years of the start date.
Responsibilities
- Plan and execute in vivo pharmacology studies to assess therapeutics against chemical toxicity.
- Participate in cell culture studies and ex vivo experiments.
- Perform immunohistochemistry and microscopy on brain tissue; conduct behavioral assessments.
- Prepare and present manuscripts and conference findings; assist with grant writing.
Skills
Education
Tools
Job description
The U.S. Army Medical Research Institute of Chemical Defense (USAMRICD) located at the Aberdeen Proving Ground in Gunpowder, MD is the Department of Defense's lead laboratory for medical chemical defense research. As a subordinate element of the U.S. Army Medical Research and Development Command (USAMRDC), USAMRICD conducts research for development of medical countermeasures to treat exposure to various chemical threat agents for protection of soldiers and civilians. Scientific disciplines at USAMRICD include, but are not limited to, chemistry, biology, biochemistry, pharmacology, molecular biology, neuroscience, toxicology, physiology, psychology, and immunology. For more information, visit us on Facebook at www.facebook.com/USAMRICD. USAMRICD is offering this research opportunity for current or recently graduated BS, MS or PhD candidates to engage in vivo studies to identify therapeutics against chemical threat agents.
Under the guidance of a mentor, you will engage in a team that collaborates on research projects involving in vivo studies to identify therapeutics against chemical threat agents. One project includes in vivo pharmacology and toxicology experiments to determine age and sex differences in chemical-induced seizure, epileptogenesis, neuroinflammation, and neurodegeneration. This study includes the evaluation of therapeutics to mitigate the effects of exposure to cholinergic-induced seizure. Methodologies include telemetry to assess EEG seizure, microscopy to assess neurodegeneration and a battery of behavioral tests to assess motor, sensorimotor, emotional, and cognitive function. A second study involves collaborating on tiered studies using cell culture, ex vivo and in vivo approaches to evaluate the toxicity of toxins (especially neurotoxins) and to assess the efficacy of therapeutics in mitigating the toxic effects. Methodologies used in the laboratory include electrophysiological techniques in cultured neuron-like cells and tension recordings in isolated nerve-muscle preparations.
- Planning and implementation of in vivo pharmacology studies to assess therapeutics against chemical-induced toxicity
- Participating in cell culture studies
- Gaining experience in ex vivo muscle tension studies (mouse diaphragm preparation)
- Participating in immunohistochemistry and microscopy studies on brain
- Conducting behavioral assays of motor, cognitive and emotional function
- Participating in small animal surgery
- Utilizing telemetric physiological assessments of brain, cardiac and motor function
- Preparing and writing manuscripts for publications
- Preparing and presenting scientific findings at conferences
- Obtaining experience with grant writing
Aberdeen Proving Ground, Maryland
USAMRICD is prepared to begin this appointment as soon as possible and will review applications on an ongoing basis until a candidate is selected. This appointment is a 12-month research appointment, with the possibility to be renewed for additional research periods. Appointments may be extended depending on funding availability, project assignment, program rules, and availability of the participant. For inquiries, please contact Lucille.a.lange.civ@health.mil.
You will receive a stipend to be determined by USAMRICD. The stipend will be commensurate with education and experience.
- Health Insurance Supplement (Participants are eligible to purchase health insurance through ORISE)
- Relocation Allowance
- Training and Travel Allowance
This program, administered by Oak Ridge Associated Universities (ORAU) through its contract with the U.S. Department of Energy (DOE) to manage the Oak Ridge Institute for Science and Education (ORISE), was established through an interagency agreement between DOE and DoD. Participants do not enter into an employee/employer relationship with ORISE, ORAU, DoD or any other office or agency. Instead, you will be affiliated with ORISE for the administration of the appointment through the ORISE appointment letter and Terms of Appointment. Proof of health insurance is required for participation in this program. Health insurance can be obtained through ORISE. For more information, visit the ORISE Research Participation Program at the U.S. Department of Defense.
Eligible candidates are currently pursuing or possess a Bachelor's, Master's or Doctoral Degree in Neuroscience, Physiology, Pharmacology, Toxicology or other eligible STEM discipline. Degree must have been received within 5 years of the appointment start date. U.S. military veterans who have been honorably discharged (or who have been medically discharged because of a service-connected disability) and who received a bachelor's master's or doctoral degree within ten years of the desired start date are also eligible. Experience with in vivo studies in small animals, cell culture and/or ex vivo preparation is preferred. Microscopy experience and excellent writing skills preferred.
US Citizenship required.
Dr. Lucille Lumley (Lange) is a Neuroscientist whose research is primarily in the area of Nerve Agent Countermeasures, with the objective to mitigate the acute and long-term effects of exposure to organophosphorus nerve agents. The focus of Dr. Lumley’s research is on the toxic effects of exposure to chemical agents and on the efficacy of therapeutics in mitigating this toxicity. Particular focus has been on the identification of efficacious anti-seizure medications to reduce the neuropathological effects of benzodiazepine refractory status epilepticus that follows nerve agent exposure when treatment is delayed. Bibliography with this URL: http://www.ncbi.nlm.nih.gov/sites/myncbi/1TCn-bKqBU0kF/bibliograpahy/48613537/public/?sort=date&direction=ascending
- Zintellect Profile
- Educational and Employment History
- Essay Questions (goals, experiences, and skills relevant to the opportunity)
- Resume (PDF)
- Transcripts/Academic Records - For this opportunity, an unofficial transcript or copy of the student academic records printed by the applicant or by academic advisors from internal institution systems may be submitted. Click here for detailed information about acceptable transcripts.
- Two Recommendations. We encourage you to contact your recommenders as soon as you start your application to ensure they are able to complete the recommendation form and to let them know to expect a message from Zintellect. Recommenders will be asked to rate your scientific capabilities, personal characteristics, and describe how they know you. You can always log back in to your Zintellect account and check the status of your application.
Kimberly
- Citizenship: U.S. Citizen Only
- Degree: Bachelor's Degree, Master's Degree, or Doctoral Degree received within the last 60 months or currently pursuing.
- Minimum Overall GPA: 3.00
- Discipline(s): Life Health and Medical Sciences
- Agricultural Sciences
- Agriculture
- Agronomy and Crop Science
- Anatomy
- Animal Behavior
- Animal Health and Food Safety
- Animal Sciences
- Basic Biomedical Sciences
- Biochemistry
- Bioinformatics
- Biology (General)
- Biophysics
- Botany
- Cellular and Molecular Biology
- Comparative Medicine and Laboratory Animal Medicine
- Computational Biology
- Developmental Biology
- Ecology
- Ecosystem Ecology
- Emergency and Incident Management
- Entomology
- Environmental Health
- Epidemiology
- Evolutionary Biology
- Food Sciences and Technology
- Genetics, including Genome Sciences
- Health Physics
- Horticulture
- Immunology
- Industrial Hygiene
- Infectious Diseases and Zoonoses
- Kinesiology and Exercise Physiology
- Microbiology
- Neurosciences
- Nutritional Sciences
- Occupational Health
- Pharmacology
- Pharmacy
- Physiology
- Plant Sciences
- Population and Community Ecology
- Population Medicine
- Public Health
- Structural Biology
- Toxicology
- Veterinary Sciences
- Virology
- Wildlife Sciences
- Zoology (General)
- Veteran Status: Veterans Preference, degree received within the last 120 month(s).
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