Mixed Modality (Peptide Upstream) Advisor - Process Translation and Execution Lilly Medicine Foundry

Eli Lilly and Company; Lebanon (IN); On-site; USD 131,000 - 211,000; Full time

Benefits offered by this job

401(k) matching

Pension plan

Vacation benefits

Medical, dental, vision benefits

Flexible benefits

Life insurance

Time off and leave benefits

Well-being programs

Job summary

Lilly Medicine Foundry in Lebanon, Indiana, and the Lilly Technology Center in Indianapolis seek experienced chemists to lead peptide upstream process transfer from development to manufacturing, ensuring scalable, compliant cGMP operations for clinical supply.

The role emphasizes SPPS, cleavage and precipitation, process optimization, and collaboration across safety, QA, and manufacturing teams to drive rapid, reliable plant readiness and continuous improvement.

Qualifications

• Ph.D./M.S./B.S. with relevant peptide chemistry/manufacturing experience.
• Experience in peptide upstream processes and scale-up.
• Solid phase peptide synthesis (SPPS) and cleavage/deprotection knowledge.

Responsibilities

• Lead transfer of peptide upstream processes to manufacturing.
• Ensure plant readiness and process fit for kilo-scale production.
• Conduct root cause analysis and troubleshooting of peptide processes.
• Collaborate with safety, process engineering, and analytical groups.
• Prepare batch records, tech transfer plans, SOPs and deviation reports.

Skills

Peptide chemistry

SPPS

Scale-up

Cross-functional collaboration

Analytical techniques

Root cause analysis

Education

Ph.D. in chemistry or related field

M.S. in chemistry or related field

B.S. in chemistry or related field

Tools

HPLC/UPLC

LC-MS

GC

NMR

Job description

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Overview:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader, headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Organization and Position Overview

Lilly recently announced a $4.5 billion investment to create the Lilly Medicine Foundry, a new center for advanced manufacturing and drug development, Lebanon, Indiana. The first-ever facility of its kind, combining research and manufacturing in a single location, the Medicine Foundry will allow Lilly to further develop innovative solutions to optimize manufacturing processes and increase capacity for clinical trial medicines, while also reducing costs and environmental impact. The Process Translation and Execution (PTE) team translates API/DS process knowledge into clinical supply readiness, oversees technology transfer, implements phase-appropriate control strategies, and ensures right-first-time clinical manufacturing for a variety of modalities, including synthetic molecules, biologics, peptides, oligonucleotide, and bioconjugates (ADC, ARC, etc.) Through cross-functional collaboration, PTE influences process design, revolutionizes clinical manufacturing, builds capabilities in emerging technologies and aligns with corporate and Lilly Research Labs (LRL) goals, drives scientific excellence and innovation to accelerate manufacturing advancements and propels the site toward long-term business success. In the Foundry Construction and Project Delivery/Startup Phase (2025 to 2028), roles will be fluid and dynamic as we build a new organization, design and implement the necessary systems and business processes required to enable operational readiness, support the project delivery, and build the site culture. Success will require significant collaboration, creativity, and resilience as the Lilly Medicine Foundry transitions from design to startup and ultimately to steady-state operations and continuous improvement. This period presents a unique opportunity for learning, growth, and making a lasting impact. We are seeking passionate and agile chemists to join the PTE team and help bring the Lilly Medicine Foundry’s vision to life.

Responsibilities

Responsibilities In this role, the Mixed Modality (Peptide Upstream) advisor will be responsible with synthetically evaluating and facilitating the transfer of peptide upstream manufacturing processes, under appropriate supervisory guidance, from development laboratories to pilot plant operations (including kilo-scale and isolator production environments). This enables the successful transition to early-phase cGMP manufacturing of grams to kilogram quantities of API required for clinical trial supply. Oversee the successful transfer of new peptide processes from development to manufacturing; ensure scalability and process fit to plant; apply scientific knowledge to troubleshoot production issues and implement new technologies or procedures. Assess peptide synthetic routes from early phase process research and development labs Familiarity with performing peptide upstream procedures, such as SPPS and Cleavage & Precipitation. Evaluate the safety of the incoming procedures in collaboration with the safety group and process engineering. Ordering and staging chemicals. Obtain reference materials and participate in setting up analytical methods. Reprocess and analyze analytical data to make fact-based decisions. Efficient with summarizing and presenting chemistry and challenges. Lead familiarization executions to ensure plant readiness of process steps including SPPS and Cleavage & Precipitation at the Lilly Medicine Foundry. Perform use-tests of key raw materials and document Definitive Lab Trials of processes to confirm plant readiness. · Documentation: Author, review technical documents, including tech transfer plan, standard operating procedures (SOPs), batch records, campaign summary reports, and deviation reports. Process improvement: Apply scientific knowledge to identify areas for improvement and implement new technologies or procedures. Lead process troubleshooting and investigations by supporting process deviations, quality events, and non-conformances. Collaborate with teams to perform root cause analysis (RCA) and develop effective corrective and preventive actions (CAPAs) Basic Requirements: B.S., M.S., or Ph.D. in chemistry, chemical engineering, or related field. B.S. with 8+ years, M.S. with 5+ years, or Ph.D. with 2+ years of experience in peptide chemistry and/or manufacturing environments involving synthetic peptide API or drug substance. Solid phase peptide synthesis is preferred. Additional Preferences: Strong knowledge of peptide chemistry and mechanisms and application to reaction improvement and optimization. Experience with synthetic chemistry techniques used for developing and scaling-up chemical reactions. Experience using process chemistry concepts is a plus. Proficiency with the synthesis of peptide crude via solid phase peptide synthesis and cleavage & deprotection. Comfortable working with larger sized equipment. Highly motivated, able to learn rapidly, and demonstrates strong attention to detail. Has experience creating batch records and conducting scale-up experiments according to those records. Ability to prioritize multiple activities and manage ambiguity. Experience with a variety of analytical techniques: HPLC/UPLC, LC-MS, GC, NMR, etc. Process quantification and acquiring mass balance for products and by-products. Demonstrated ability to drive projects and accept change. Communication skills: Excellent written and verbal communication skills for technical report writing, presentations, and effective collaboration across teams Familiarity with peptide downstream purification, TFF, lyophilization and understanding of precipitation and safe handling of solids/dry end processing. Problem-solving skills: Proven ability to analyze data, perform root cause analysis, and resolve complex technical challenges. Ability to work cross-functionally across disciplines and levels with engineers, analytical chemists, chemical technicians, safety and quality representatives. Other Information: Initial location at Lilly Technology Center, Indianapolis. Permanent location at the new Lilly Medicines Foundry in Lebanon, Indiana. Limited domestic and international travel (< 5%) may be required for this role Role requires ability to work in manufacturing and laboratory environments Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status. #WeAreLilly Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL). #WeAreLilly At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people. We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe! #WeAreLilly

Salary and Benefits

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $130,500 - $211,200. Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance).

Benefits:

• including eligibility to participate in a company-sponsored 401(k)
• pension
• vacation benefits
• eligibility for medical, dental, vision and prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)