Member of the Technical Staff, Generative

Output Biosciences; New York (NY); On-site; USD 120,000 - 160,000; Full time

Benefits offered by this job

Competitive salary and equity

Excellent medical, dental, and vision coverage

Feedback-focused environment

Ownership of day-to-day management

Job summary

Output Biosciences, based in New York, NY, is seeking a lead in generative model development in a pioneering AI x Bio setting. The successful candidate will have a strong background in machine learning, demonstrated through hands-on experience in designing and training generative models, particularly in molecular sciences.

The role demands a PhD or equivalent experience, proficiency in Python and PyTorch, with a commitment to innovative research and practical impact in therapy development. A competitive salary and equity are offered, alongside comprehensive medical benefits.

Qualifications

• 2+ years of post-doctoral or industry research experience.
• Strong publication record in top-tier venues.
• Hands-on experience designing, building, and training deep generative models.
• Proficient in Python and PyTorch.
• Ability to own the full research-to-training pipeline.
• Production-quality code that's well-tested and maintainable.

Responsibilities

• Lead the design and development of generative models.
• Develop training approaches and methods for controllable generation.
• Integrate biological reasoning into the generative pipeline.
• Own training end-to-end with hyperparameter optimization.
• Design evaluation frameworks for biologically meaningful molecules.

Skills

Generative modeling

Deep learning

Python

PyTorch

Experimental design

Education

PhD in computer science, machine learning, physics, mathematics, or a related field

Bachelor's or Master's in related fields with 5+ years of experience

Tools

Multi-GPU infrastructure

Job description

Output has built a biological reasoning model that understands biology at the scale and complexity life actually operates. Our model independently learned the principles of molecular interactions, opening up drug treatments that were previously impossible. We're already generating therapies that traditional approaches cannot reach. The hardest problems in both AI and biology are being solved here, and there is room for you to own one.

Output is currently in stealth, operated by a team of repeat founders and biotech veterans with multiple exits in AI x Bio, and backed by top-tier VCs including Y Combinator.

You will lead the design and development of Output's generative models, working across molecular modalities to build systems that produce novel, biologically grounded molecules. This role spans the full arc from research to trained model: you design architectures, develop training approaches, run experiments on distributed GPU clusters, and evaluate results.

• You will design and build generative architectures for molecular data spanning multiple modalities, including small molecules, peptides, mini proteins and more.
• You will develop training approaches that learn from diverse biological signal, ensuring the model composes genuinely novel structures.
• You will build methods for controllable, targeted generation, enabling the model to produce molecules with specified biological properties while satisfying real-world chemical constraints.
• You will integrate biological reasoning from our foundation model into the generative pipeline, using learned biological representations to guide and condition generation.
• You will own training end-to-end: experiment design, distributed training on multi-GPU clusters, hyperparameter optimization, and iteration.
• You will design evaluation frameworks that go beyond statistical metrics to measure whether generated molecules are biologically meaningful, structurally valid, and genuinely novel.

About You

• You have a PhD in computer science, machine learning, physics, mathematics, or a related field with 2+ years of post-doctoral or industry research experience, or a Bachelor's or Master's degree with 5+ years of hands-on research and engineering experience in generative modeling.
• You have a strong publication record in generative methods at top-tier venues (e.g., NeurIPS, ICML, ICLR).
• You have extensive hands-on experience designing, building, and training deep generative models, including work on novel architectures, training objectives, or sampling methods.
• You are proficient in Python and PyTorch, and have experience training models on distributed multi-GPU infrastructure.
• You have demonstrated the ability to own the full research-to-training pipeline: you do not just design methods, you train and ship models.
• You write production-quality code that is well-tested and maintainable, and you are comfortable working in shared codebases with version control and code review.
• You are a rigorous experimentalist who designs evaluations carefully, tracks experiments systematically, and draws conclusions from data.

Bonus Points

• You have experience applying generative models to molecular, chemical, or biological data.
• You have a background in chemistry, biology, computational biology, biophysics, or a related natural science.
• You have experience with multi-modal learning or cross-modality translation.
• You have experience with conditional or controllable generation methods.
• You have contributed to open-source machine learning projects.

Our Values

• Heart: We foster a culture of ownership. We are assembling a team of individuals who are passionate and take pride in their contributions.
• Excellence: We have an unwavering commitment to excellence and continuously challenge ourselves to reach the highest standards.
• Practicality: We value practicality and results-oriented thinking. We are committed to making a tangible impact on the lives of patients and the broader community.
• Honesty: We place a high value on honesty and directness. We firmly believe in addressing issues as they arise, in an open and transparent manner.
• Fun: We believe that life is too short to not have fun. Our goal is to create a workplace that is fun, engaging, rewarding and fulfilling.

What We Offer

• We encourage new and different ideas, creativity and contrarian thinking.
• Healthy feedback-focused environment to help you strive - leadership will have high expectations, regularly share constructive feedback, support you and help you grow, and welcome receiving feedback and ideas from you.
• You own your day-to-day management. What we care about is that we all hit our milestones.
• Competitive salary and equity in a growing, well-funded startup.
• Excellent medical, dental, and vision coverage.