Medical Director, Clinical Development – Neurology

Denali Therapeutics Inc; South San Francisco (CA); On-site; USD 272,000 - 336,000; Full time

Benefits offered by this job

401k

Healthcare coverage

ESPP

Job summary

Denali Therapeutics Inc. in South San Francisco is seeking a Medical Director, Clinical Development to provide clinical leadership for enzyme replacement programs and help shape development strategy in neurology and rare diseases.

The role involves leading trial design, safety monitoring, regulatory documentation, cross-functional collaboration, and external engagement, with mentorship of the clinical science team and a strong emphasis on patient-centric, high-quality science.

Qualifications

• MD/MD-PhD with neurology focus.
• Minimum of 3+ years of post-training clinical development experience in industry or equivalent.
• Proven ability to lead cross-functional teams in a biopharmaceutical environment.
• Experience planning and executing therapeutic trials for neurological indications.
• Strong understanding of biomarker-driven strategies and medical monitoring.

Responsibilities

• Provide clinical leadership on one or more programs, including CDPs.
• Oversee clinical science aspects of trial design, execution, interpretation, and reporting (safety, pharmacodynamics, efficacy).
• Collaborate cross-functionally with translational, regulatory, statistical, clinical operations, and safety teams.

Skills

MD/MD-PhD

Neurology focus

Clinical development leadership

Trial design & execution

Biomarker strategies

Education

MD or MD-PhD

Job description

Denali Therapeutics Inc. in South San Francisco is seeking a Medical Director, Clinical Development to provide clinical leadership for enzyme replacement programs and help shape development strategy in neurology and rare diseases.

The role involves leading trial design, safety monitoring, regulatory documentation, cross-functional collaboration, and external engagement, with mentorship of the clinical science team and a strong emphasis on patient-centric, high-quality science.